Apolipoprotein nanodiscs with telodendrimer
Abstract
The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R).sub.n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1356293
- Patent Number(s):
- 9644038
- Application Number:
- 13/719,785
- Assignee:
- The Regents of the University of California
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 Dec 19
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, Coleman, Matthew, Cheng, R. Holland, and Xing, Li. Apolipoprotein nanodiscs with telodendrimer. United States: N. p., 2017.
Web.
Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, Coleman, Matthew, Cheng, R. Holland, & Xing, Li. Apolipoprotein nanodiscs with telodendrimer. United States.
Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, Coleman, Matthew, Cheng, R. Holland, and Xing, Li. Tue .
"Apolipoprotein nanodiscs with telodendrimer". United States. https://www.osti.gov/servlets/purl/1356293.
@article{osti_1356293,
title = {Apolipoprotein nanodiscs with telodendrimer},
author = {Luo, Juntao and He, Wei and Lam, Kit S. and Henderson, Paul and Coleman, Matthew and Cheng, R. Holland and Xing, Li},
abstractNote = {The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R).sub.n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 09 00:00:00 EDT 2017},
month = {Tue May 09 00:00:00 EDT 2017}
}
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Works referenced in this record:
Method for forming proteoliposome and method for forming giant proteoliposome
patent, December 1994
- Kanno, Tsunehiro; Ohyama, Junji; Sakuranaga, Masanori
- US Patent Document 5,374,715
Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof
patent, April 2002
- Burman, Anand C.; Mukherjee, Rama; Khattar, Dhiraj
- US Patent Document 6,365,191
Membrane scaffold proteins
patent, August 2006
- Sligar, Stephen G.; Bayburt, Timothy H.; Schuler, Mary A.
- US Patent Document 7,083,958
Lipophilic drug delivery vehicle and methods of use thereof
patent, November 2010
- Ryan, Robert; Oda, Michael N.
- US Patent Document 7,824,709
Novel targeted delivery systems for bioactive agents
patent-application, April 2002
- Unger, Evan; Matsunaga, Terry Onichi; Ramaswami, Varadarajan
- US Patent Application 09/912609; 20020041898
Water soluble chitosan nanoparticle for delivering an anticancer agent and preparing method thereof
patent-application, January 2006
- Nah, Jae-Woon; Jung, Teok Rae; Jang, Mi-Kyeong
- US Patent Application 11/128297; 20060013885
Amplification of biotin-mediated targeting
patent-application, June 2006
- Russell-Jones, Gregory; Mcewan, John
- US Patent Application 10/535269; 20060127310
In Vitro Protein Synthesis Systems For Membrane Proteins That Include Adolipoproteins And Phospholipid-Adolipoprotein Particles
patent-application, May 2007
- Kudlicki, Wieslaw; Fletcher, Julia; Katzen, Federico
- US Patent Application 11/535960; 20070117179
Drug-Polymer Conjugates Coupled to a Peptidic Carrier
patent-application, August 2008
- Sinko, Patrick; Stein, Stanley; Gunaseelan, Simi
- US Patent Application 11/816317; 20080188399
Isolated Phospholipid-Protein Particles
patent-application, October 2008
- Katzen, Federico; Fletcher, Julia; Kudlicki, Wieslaw
- US Patent Application 12/040798; 20080248565
Methods and Systems for Monitoring Production of a Target Protein In a Nanolipoprotein Particle
patent-application, May 2009
- Coleman, Matthew A.; Hoeprich, Paul D.; Arroyo, Erin S.
- US Patent Application 12/118530; 20090136937
Nanolipoprotein Particles Comprising Hydrogenases and Related Products, Methods and Systems
patent-application, July 2009
- Baker, Sarah E.; Chromy, Brett A.; Henderson, Paul
- US Patent Application 12/352472; 20090186393
Nanolipoprotein Particles And Related Methods And Systems For Protein Capture, Solubilization, And/Or Purification
patent-application, July 2009
- Chromy, Brett A.; Henderson, Paul; Hoeprich, Jr., Paul D.
- US Patent 12/352548; 20090192299
Lysine-Based Polymeric Linkers
patent-application, August 2009
- Zhao, Hong; Reddy, Prasanna
- US Patent Application 12/402980; 20090203706
Nanolipoprotein Particles and Related Compositions, Methods and Systems
patent-application, December 2009
- Hoeprich, Paul D.; Fischer, Nicholas O.; Mason, Peter W.
- US Patent Application 12/469533; 20090311276
Immunostimulatory Nanoparticles and Related Compositions, Methods and Systems
patent-application, April 2010
- Hoeprich, Paul D.; Fischer, Nicholas O.; Blanchette, Craig
- US Patent Application 12/604362; 20100092567
Nanoparticles for Delivery of Therapeutic Agents Using Ultrasound and Associated Methods
patent-application, June 2010
- Watkin, Kenneth L.
- US Patent Application 12/694891; 20100158994
Nanocarriers for Drug Delivery
patent-application, November 2011
- Lam, Kit; Luo, Juntao
- US Patent Application 13/120140; 20110286915
Telodendrimer Nanodiscs Without Apolipoprotein
patent-application, June 2013
- Lam, Kit S.; Luo, Juntao; Lee, Joyce S.
- US Patent Application 13/719766; 20130164369
Fluorescence Study of Inclusion Complexes between Star-Shaped Cholic Acid Derivatives and Polycyclic Aromatic Fluorescent Probes and the Size Effects of Host and Guest Molecules
journal, March 2008
- Chen, Yilong; Luo, Juntao; Zhu, X. X.
- The Journal of Physical Chemistry B, Vol. 112, Issue 11, p. 3402-3409
The dawning era of polymer therapeutics
journal, May 2003
- Duncan, Ruth
- Nature Reviews Drug Discovery, Vol. 2, Issue 5, p. 347-360
Asymmetric Poly(ethylene glycol) Star Polymers with a Cholic Acid Core and Their Aggregation Properties
journal, April 2009
- Luo, Juntao; Giguère, Guillaume; Zhu, X. X.
- Biomacromolecules, Vol. 10, Issue 4, p. 900-906
A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer
journal, October 2009
- Xiao, Kai; Luo, Juntao; Fowler, Wiley L.
- Biomaterials, Vol. 30, Issue 30, p. 6006-6016
PEG-oligocholic acid telodendrimer micelles for the targeted delivery of doxorubicin to B-cell lymphoma
journal, October 2011
- Xiao, Kai; Luo, Juntao; Li, Yuanpei
- Journal of Controlled Release, Vol. 155, Issue 2, p. 272-281
A Simple Construction of a Bile Acid Based Dendritic Light Harvesting System
journal, June 2005
- Vijayalakshmi, N.; Maitra, Uday
- Organic Letters, Vol. 7, Issue 13, p. 2727-2730