Radioisotope trithiol complexes
Abstract
The present invention is directed to a series of stable radioisotope trithiol complexes that provide a simplified route for the direct complexation of radioisotopes present in low concentrations. In certain embodiments, the complex contains a linking domain configured to conjugate the radioisotope trithiol complex to a targeting vector. The invention is also directed to a novel method of linking the radioisotope to a trithiol compound to form the radioisotope trithiol complex. The inventive radioisotope trithiol complexes may be utilized for a variety of applications, including diagnostics and/or treatment in nuclear medicine.
- Inventors:
- Issue Date:
- Research Org.:
- THE CURATORS OF THE UNIVERSITY OF MISSOURI, Columbia, MO (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1344768
- Patent Number(s):
- 9427483
- Application Number:
- 14/679,520
- Assignee:
- THE CURATORS OF THE UNIVERSITY OF MISSOURI (Columbia, MO)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- SC0003851
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2015 Apr 06
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE
Citation Formats
Jurisson, Silvia S., Cutler, Cathy S., and Degraffenreid, Anthony J. Radioisotope trithiol complexes. United States: N. p., 2016.
Web.
Jurisson, Silvia S., Cutler, Cathy S., & Degraffenreid, Anthony J. Radioisotope trithiol complexes. United States.
Jurisson, Silvia S., Cutler, Cathy S., and Degraffenreid, Anthony J. Tue .
"Radioisotope trithiol complexes". United States. https://www.osti.gov/servlets/purl/1344768.
@article{osti_1344768,
title = {Radioisotope trithiol complexes},
author = {Jurisson, Silvia S. and Cutler, Cathy S. and Degraffenreid, Anthony J.},
abstractNote = {The present invention is directed to a series of stable radioisotope trithiol complexes that provide a simplified route for the direct complexation of radioisotopes present in low concentrations. In certain embodiments, the complex contains a linking domain configured to conjugate the radioisotope trithiol complex to a targeting vector. The invention is also directed to a novel method of linking the radioisotope to a trithiol compound to form the radioisotope trithiol complex. The inventive radioisotope trithiol complexes may be utilized for a variety of applications, including diagnostics and/or treatment in nuclear medicine.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 30 00:00:00 EDT 2016},
month = {Tue Aug 30 00:00:00 EDT 2016}
}
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