Title: Identification of cancer protein biomarkers using proteomic techniques

Abstract

The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein. The biomarkers identified herein can also be used in the prognosis and monitoring of cancer. The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer.

Inventors:

Mor, Gil G.; Ward, David C.; Bray-Ward, Patricia

Issue Date:

Tue Oct 18 00:00:00 EDT 2016

Research Org.:

Yale Univ., New Haven, CT (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1329309

Patent Number(s):

9470688

Application Number:

14/602,916

Assignee:

Yale University (New Haven, CT

Patent Classifications (CPCs):

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/6886 - for cancer
C12Q2600/112 - Disease subtyping, staging or classification
C12Q2600/136 - Screening for pharmacological compounds
C12Q2600/158 - Expression markers

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N2333/4703 - Regulators
G01N2333/575 - Hormones
G01N2333/5756 - Prolactin
G01N2333/65 - Insulin-like growth factors
G01N2333/99 - Isomerases
G01N2500/04 - Screening involving studying the effect of compounds C directly on molecule A
G01N2800/52 - Predicting or monitoring the response to treatment
G01N33/57415 - {of breast}
G01N33/57419 - {of colon}
G01N33/57449 - {of ovaries}
G01N33/57484 - {involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites}

G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16Z - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR

G16Z99/00 - Subject matter not provided for in other main groups of this subclass

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DOE Contract Number:  

FG02-ER63462

Resource Type:

Patent

Resource Relation:

Patent File Date: 2015 Jul 22

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES