Use of Galerina marginata genes and proteins for peptide production

Hallen-Adams, Heather E.; Scott-Craig, John S.; Walton, Jonathan D.; Luo, Hong

Advanced Search OptionsAdvanced Search queries use a traditional Term Search. For more info, see our FAQ.

All Fields:

Patent Title:

Abstract:

Assignee:

Inventor(s):

Patent Number:

Patent Classification (CPC):

All Classifications
A - human necessities
A01 - agriculture
A21 - baking
A22 - butchering
A23 - foods or foodstuffs
A24 - tobacco
A41 - wearing apparel
A42 - headwear
A43 - footwear
A44 - haberdashery
A45 - hand or travelling articles
A46 - brushware
A47 - furniture
A61 - medical or veterinary science
A62 - life-saving
A63 - sports
A99 - subject matter not otherwise provided for in this section
B - performing operations
B01 - physical or chemical processes or apparatus in general
B02 - crushing, pulverising, or disintegrating
B03 - separation of solid materials using liquids or using pneumatic tables or jigs
B04 - centrifugal apparatus or machines for carrying-out physical or chemical processes
B05 - spraying or atomising in general
B06 - generating or transmitting mechanical vibrations in general
B07 - separating solids from solids
B08 - cleaning
B09 - disposal of solid waste
B21 - mechanical metal-working without essentially removing material
B22 - casting
B23 - machine tools
B24 - grinding
B25 - hand tools
B26 - hand cutting tools
B27 - working or preserving wood or similar material
B28 - working cement, clay, or stone
B29 - working of plastics
B30 - presses
B31 - making articles of paper, cardboard or material worked in a manner analogous to paper
B32 - layered products
B33 - additive manufacturing technology
B41 - printing
B42 - bookbinding
B43 - writing or drawing implements
B44 - decorative arts
B60 - vehicles in general
B61 - railways
B62 - land vehicles for travelling otherwise than on rails
B63 - ships or other waterborne vessels
B64 - aircraft
B65 - conveying
B66 - hoisting
B67 - opening, closing {or cleaning} bottles, jars or similar containers
B68 - saddlery
B81 - microstructural technology
B82 - nanotechnology
B99 - subject matter not otherwise provided for in this section
C - chemistry
C01 - inorganic chemistry
C02 - treatment of water, waste water, sewage, or sludge
C03 - glass
C04 - cements
C05 - fertilisers
C06 - explosives
C07 - organic chemistry
C08 - organic macromolecular compounds
C09 - dyes
C10 - petroleum, gas or coke industries
C11 - animal or vegetable oils, fats, fatty substances or waxes
C12 - biochemistry
C13 - sugar industry
C14 - skins
C21 - metallurgy of iron
C22 - metallurgy
C23 - coating metallic material
C25 - electrolytic or electrophoretic processes
C30 - crystal growth
C40 - combinatorial technology
C99 - subject matter not otherwise provided for in this section
D - textiles
D01 - natural or man-made threads or fibres
D02 - yarns
D03 - weaving
D04 - braiding
D05 - sewing
D06 - treatment of textiles or the like
D07 - ropes
D10 - indexing scheme associated with sublasses of section d, relating to textiles
D21 - paper-making
D99 - subject matter not otherwise provided for in this section
E - fixed constructions
E01 - construction of roads, railways, or bridges
E02 - hydraulic engineering
E03 - water supply
E04 - building
E05 - locks
E06 - doors, windows, shutters, or roller blinds in general
E21 - earth drilling
E99 - subject matter not otherwise provided for in this section
F - mechanical engineering
F01 - machines or engines in general
F02 - combustion engines
F03 - machines or engines for liquids
F04 - positive - displacement machines for liquids
F05 - indexing schemes relating to engines or pumps in various subclasses of classes f01-f04
F15 - fluid-pressure actuators
F16 - engineering elements and units
F17 - storing or distributing gases or liquids
F21 - lighting
F22 - steam generation
F23 - combustion apparatus
F24 - heating
F25 - refrigeration or cooling
F26 - drying
F27 - furnaces
F28 - heat exchange in general
F41 - weapons
F42 - ammunition
F99 - subject matter not otherwise provided for in this section
G - physics
G01 - measuring
G02 - optics
G03 - photography
G04 - horology
G05 - controlling
G06 - computing
G07 - checking-devices
G08 - signalling
G09 - education
G10 - musical instruments
G11 - information storage
G12 - instrument details
G16 - information and communication technology [ict] specially adapted for specific application fields
G21 - nuclear physics
G99 - subject matter not otherwise provided for in this section
H - electricity
H01 - basic electric elements
H02 - generation
H03 - basic electronic circuitry
H04 - electric communication technique
H05 - electric techniques not otherwise provided for
H99 - subject matter not otherwise provided for in this section
Y - new / cross sectional technologies
Y02 - technologies or applications for mitigation or adaptation against climate change
Y04 - information or communication technologies having an impact on other technology areas
Y10 - technical subjects covered by former uspc

More Options ...

Title: Use of Galerina marginata genes and proteins for peptide production

Abstract

The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.

Inventors:: Hallen-Adams, Heather E.; Scott-Craig, John S.; Walton, Jonathan D.; Luo, Hong

Issue Date:: Tue Mar 01 00:00:00 EST 2016

Research Org.:: Michigan State Univ., East Lansing, MI (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1241031

Patent Number(s):: 9273100

Application Number:: 13/362,561

Assignee:: Board of Trustees of Michigan State University (East Lansing, MI)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

Show more

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/375 - from Basidiomycetes
C07K7/64 - Cyclic peptides containing only normal peptide links

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N9/58 - derived from fungi

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C12P21/06 - produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
C12Y304/21026 - Prolyl oligopeptidase

Show less

DOE Contract Number:: FG02-91ER20021

Resource Type:: Patent

Resource Relation:: Patent File Date: 2012 Jan 31

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; 54 ENVIRONMENTAL SCIENCES

Citation Formats


                    Hallen-Adams, Heather E., Scott-Craig, John S., Walton, Jonathan D., and Luo, Hong. Use of Galerina marginata genes and proteins for peptide production.  United States: N. p., 2016. 
        Web.

Copy to clipboard


                    Hallen-Adams, Heather E., Scott-Craig, John S., Walton, Jonathan D., & Luo, Hong. Use of Galerina marginata genes and proteins for peptide production.  United States.

Copy to clipboard


                    Hallen-Adams, Heather E., Scott-Craig, John S., Walton, Jonathan D., and Luo, Hong. Tue .  
        "Use of Galerina marginata genes and proteins for peptide production".  United States.  https://www.osti.gov/servlets/purl/1241031.

Copy to clipboard


                    
@article{osti_1241031,

  title        = {Use of Galerina marginata genes and proteins for peptide production},

  author       = {Hallen-Adams, Heather E. and Scott-Craig, John S. and Walton, Jonathan D. and Luo, Hong},

  abstractNote = {The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Mar 01 00:00:00 EST 2016},

  month        = {Tue Mar 01 00:00:00 EST 2016}

}

Copy to clipboard

Patent:

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

An Extended Physical Map of the TOX2 Locus of Cochliobolus carbonum Required for Biosynthesis of HC-Toxin
journal, February 2002

Ahn, Joong-Hoon; Cheng, Yi-Qiang; Walton, Jonathan D.
Fungal Genetics and Biology, Vol. 35, Issue 1, p. 31-38
https://doi.org/10.1006/fgbi.2001.1305

Proteins of the ADF/Cofilin Family: Essential Regulators of Actin Dynamics
journal, November 1999

Bamburg, James R.
Annual Review of Cell and Developmental Biology, Vol. 15, Issue 1, p. 185-230
https://doi.org/10.1146/annurev.cellbio.15.1.185

Chemical Variation in Amanita
journal, July 1981

Beutler, John A.; Der Marderosian, Ara H.
Journal of Natural Products, Vol. 44, Issue 4, p. 422-431
https://doi.org/10.1021/np50016a005

Suggested functions for prolyl oligopeptidase: A puzzling paradox
journal, February 2007

Brandt, Inger; Scharpe, Simon; Lambeir, Anne-Marie
Clinica Chimica Acta, Vol. 377, Issue 1-2, p. 50-61
https://doi.org/10.1016/j.cca.2006.09.001

Efficient oxidative folding of conotoxins and the radiation of venomous cone snails
journal, October 2003

Bulaj, Grzegorz; Buczek, Olga; Goodsell, Ian
Proceedings of the National Academy of Sciences, Vol. 100, Issue Supplement 2, p. 14562-14568
https://doi.org/10.1073/pnas.2335845100

Structural basis of transcription: α-Amanitin-RNA polymerase II cocrystal at 2.8 Å resolution
journal, January 2002

Bushnell, David A.; Cramer, Patrick; Kornberg, Roger D.
Proceedings of the National Academy of Sciences, Vol. 99, Issue 3, p. 1218-1222
https://doi.org/10.1073/pnas.251664698

Seamless Proteins Tie Up Their Loose Ends
journal, March 2006

Craik, David J.
Science, Vol. 311, Issue 5767, p. 1563-1564
https://doi.org/10.1126/science.1125248

WebLogo: A Sequence Logo Generator
journal, May 2004

Crooks, Gavin E.; Hon, Gary; Chandonia, John-Marc
Genome Research, Vol. 14, Issue 6, p. 1188-1190
https://doi.org/10.1101/gr.849004

Proline specific peptidases
journal, December 1997

Cunningham, Damian F.; O'Connor, Brendan
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol. 1343, Issue 2, p. 160-186
https://doi.org/10.1016/S0167-4838(97)00134-9

Two Enzymes Catalyze the Maturation of a Lasso Peptide in Escherichia coli
journal, July 2007

Duquesne, Sophie; Destoumieux-Garzon, Delphine; Zirah, Severine
Chemistry & Biology, Vol. 14, Issue 7, p. 793-803
https://doi.org/10.1016/j.chembiol.2007.06.004

Treatment of Amatoxin Poisoning: 20-Year Retrospective Analysis
journal, January 2002

Enjalbert, Francoise; Rapior, Sylvie; Nouguier-Soule, Janine
Journal of Toxicology: Clinical Toxicology, Vol. 40, Issue 6, p. 715-757
https://doi.org/10.1081/CLT-120014646

Molecular diversification in spider venoms: A web of combinatorial peptide libraries
journal, November 2006

Escoubas, Pierre
Molecular Diversity, Vol. 10, Issue 4, p. 545-554
https://doi.org/10.1007/s11030-006-9050-4

Biosynthesis of Nonribosomal Peptides
journal, October 2004

Finking, Robert; Marahiel, Mohamed A.
Annual Review of Microbiology, Vol. 58, Issue 1, p. 453-488
https://doi.org/10.1146/annurev.micro.58.030603.123615

Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease
journal, January 2007

Garcia-Horsman, J. Arturo; Venäläinen, Jarkko I.; Lohi, Olli
Scandinavian Journal of Gastroenterology, Vol. 42, Issue 5, p. 562-571
https://doi.org/10.1080/00365520601019819

The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans
journal, July 2004

Gardiner, Donald M.; Cozijnsen, Anton J.; Wilson, Leanne M.
Molecular Microbiology, Vol. 53, Issue 5, p. 1307-1318
https://doi.org/10.1111/j.1365-2958.2004.04215.x

Prolyl endopeptidases
journal, December 2006

Gass, J.; Khosla, C.
Cellular and Molecular Life Sciences, Vol. 64, Issue 3, p. 345-355
https://doi.org/10.1007/s00018-006-6317-y

Gene expression shifts during perithecium development in Gibberella zeae (anamorph Fusarium graminearum), with particular emphasis on ion transport proteins
journal, November 2007

Hallen, Heather E.; Huebner, Marianne; Shiu, Shin-Han
Fungal Genetics and Biology, Vol. 44, Issue 11, p. 1146-1156
https://doi.org/10.1016/j.fgb.2007.04.007

Gene family encoding the major toxins of lethal Amanita mushrooms
journal, November 2007

Hallen, Heather E.; Luo, Hong; Scott-Craig, John S.
Proceedings of the National Academy of Sciences, Vol. 104, Issue 48, p. 19097-19101
https://doi.org/10.1073/pnas.0707340104

Taxonomy and toxicity of Conocybe lactea and related species
journal, August 2003

Hallen, Heather E.; Watling, Roy; Adams, Gerard C.
Mycological Research, Vol. 107, Issue 8, p. 969-979
https://doi.org/10.1017/S0953756203008190

Fungal secondary metabolism — from biochemistry to genomics
journal, December 2005

Keller, Nancy P.; Turner, Geoffrey; Bennett, Joan W.
Nature Reviews Microbiology, Vol. 3, Issue 12, p. 937-947
https://doi.org/10.1038/nrmicro1286

Size and complexity of the nuclear genome of the ectomycorrhizal fungus Paxillus involutus
journal, August 2002

Le Quere, Antoine; Johansson, Tomas; Tunlid, Anders
Fungal Genetics and Biology, Vol. 36, Issue 3, p. 234-241
https://doi.org/10.1016/S1087-1845(02)00024-5

Molecular Characterization and Inhibition of Amanitin Uptake into Human Hepatocytes
journal, February 2006

Letschert, Katrin; Faulstich, Heinz; Keller, Daniela
Toxicological Sciences, Vol. 91, Issue 1, p. 140-149
https://doi.org/10.1093/toxsci/kfj141

Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin
journal, October 1970

Lindell, Thomas J.; Weinberg, Fanyela; Morris, Paul W.
Science, Vol. 170, Issue 3956, p. 447-449
https://doi.org/10.1126/science.170.3956.447

Introns are necessary for mRNA accumulation in Schizophyllum commune
journal, May 1999

Lugones, Luis G.; Scholtmeijer, Karin; Klootwijk, Riko
Molecular Microbiology, Vol. 32, Issue 4, p. 681-689
https://doi.org/10.1046/j.1365-2958.1999.01373.x

Functional Characterization of Two Cytochrome P450 Monooxygenase Genes, P450-1 and P450-4, of the Gibberellic Acid Gene Cluster in Fusarium proliferatum (Gibberella fujikuroi MP-D)
journal, March 2005

Malonek, S.; Rojas, M. C.; Hedden, P.
Applied and Environmental Microbiology, Vol. 71, Issue 3, p. 1462-1472
https://doi.org/10.1128/AEM.71.3.1462-1472.2005

Regulation of inducible and tissue-specific gene expression
journal, June 1987

Maniatis, T.; Goodbourn, S.; Fischer, J. A.
Science, Vol. 236, Issue 4806, p. 1237-1245
https://doi.org/10.1126/science.3296191

Genome sequencing in microfabricated high-density picolitre reactors
journal, July 2005

Margulies, Marcel; Egholm, Michael; Altman, William E.
Nature, Vol. 437, Issue 7057, p. 376-380
https://doi.org/10.1038/nature03959

Tryptathionine bridges in peptide synthesis
journal, January 2007

May, Jonathan P.; Perrin, David M.
Biopolymers, Vol. 88, Issue 5, p. 714-724
https://doi.org/10.1002/bip.20807

Identification of peptide synthetase-encoding genes from filamentous fungi producing host-selective phytotoxins or analogs
journal, January 1995

Nikolskaya, Anastasia N.; Panaccione, Daniel G.; Walton, Jonathan D.
Gene, Vol. 165, Issue 2, p. 207-211
https://doi.org/10.1016/0378-1119(95)00555-K

Quorum Sensing in Staphylococci
journal, December 2008

Novick, Richard P.; Geisinger, Edward
Annual Review of Genetics, Vol. 42, Issue 1, p. 541-564
https://doi.org/10.1146/annurev.genet.42.110807.091640

Multiple families of peptide synthetase genes from ergopeptine-producing fungi
journal, April 1996

Panaccione, Daniel G.
Mycological Research, Vol. 100, Issue 4, p. 429-436
https://doi.org/10.1016/S0953-7562(96)80139-0

Liver transplantation represents the optimal treatment for fulminant hepatic failure from amanita phalloides poisoning
journal, April 2006

Panaro, Fabrizio; Andorno, Enzo; Morelli, Nicola
Transplant International, Vol. 19, Issue 4, p. 344-345
https://doi.org/10.1111/j.1432-2277.2006.00275.x

The prolyl oligopeptidase family
journal, February 2002

Polgar, L.
Cellular and Molecular Life Sciences CMLS, Vol. 59, Issue 2, p. 349-362
https://doi.org/10.1007/s00018-002-8427-5

cDNAs encoding [D-Ala2] deltorphin precursors from skin of Phyllomedusa bicolor also contain genetic information for three dermorphin-related opioid peptides
journal, June 1990

Richter, K.; Egger, R.; Negri, L.
Proceedings of the National Academy of Sciences, Vol. 87, Issue 12, p. 4836-4839
https://doi.org/10.1073/pnas.87.12.4836

Microcin J25 Has a Threaded Sidechain-to-Backbone Ring Structure and Not a Head-to-Tail Cyclized Backbone
journal, October 2003

Rosengren, K. Johan; Clark, Richard J.; Daly, Norelle L.
Journal of the American Chemical Society, Vol. 125, Issue 41, p. 12464-12474
https://doi.org/10.1021/ja0367703

Ab initio Gene Finding in Drosophila Genomic DNA
journal, April 2000

Salamov, Asaf A.; Solovyev, Victor V.
Genome Research, Vol. 10, Issue 4, p. 516-522
https://doi.org/10.1101/gr.10.4.516

Highly-efficient transformation of the homobasidiomycete Schizophyllum commune to phleomycin resistance
journal, August 1994

Schuren, Frank H. J.; Wessels, Joseph G. H.
Current Genetics, Vol. 26, Issue 2, p. 179-183
https://doi.org/10.1007/BF00313808

Identification and Analysis of Multivalent Proteolytically Resistant Peptides from Gluten: Implications for Celiac Sprue
journal, October 2005

Shan, Lu; Qiao, Shuo-Wang; Arentz-Hansen, Helene
Journal of Proteome Research, Vol. 4, Issue 5, p. 1732-1741
https://doi.org/10.1021/pr050173t

Structural Basis for Gluten Intolerance in Celiac Sprue
journal, September 2002

Shan, Lu; Molberg, Oyvind; Parrot, Isabelle
Science, Vol. 297, Issue 5590, p. 2275-2279
https://doi.org/10.1126/science.1074129

The use of heparin as a simple cost-effective means of controlling background In nudeic acid hybridization procedures
journal, January 1984

Singh, L.; Jones, K. W.
Nucleic Acids Research, Vol. 12, Issue 14, p. 5627-5638
https://doi.org/10.1093/nar/12.14.5627

Substrate- and pH-dependent contribution of oxyanion binding site to the catalysis of prolyl oligopeptidase, a paradigm of the serine oligopeptidase family
journal, January 2000

Szeltner, Zoltan; Renner, Veronika; Polgar, Laszlo
Protein Science, Vol. 9, Issue 2, p. 353-360
https://doi.org/10.1110/ps.9.2.353

The Noncatalytic β-Propeller Domain of Prolyl Oligopeptidase Enhances the Catalytic Capability of the Peptidase Domain
journal, March 2000

Szeltner, Zoltan; Renner, Veronika; Polgar, Laszlo
Journal of Biological Chemistry, Vol. 275, Issue 20, p. 15000-15005
https://doi.org/10.1074/jbc.M000942200

Circular proteins — no end in sight
journal, March 2002

Trabi, Manuela; Craik, David J.
Trends in Biochemical Sciences, Vol. 27, Issue 3, p. 132-138
https://doi.org/10.1016/S0968-0004(02)02057-1

Xerocomus chrysenteron lectin: identification of a new pesticidal protein
journal, June 2003

Trigueros, Veronique; Lougarre, Andree; Ali-Ahmed, Djamila
Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1621, Issue 3, p. 292-298
https://doi.org/10.1016/S0304-4165(03)00098-9

Characterization of the Final Two Genes of the Gibberellin Biosynthesis Gene Cluster of Gibberella fujikuroi
journal, May 2003

Tudzynski, Bettina; Mihlan, Martina; Rojas, Maria Cecilia
Journal of Biological Chemistry, Vol. 278, Issue 31, p. 28635-28643
https://doi.org/10.1074/jbc.M301927200

Gibberellin Biosynthetic Pathway in Gibberella fujikuroi: Evidence for a Gene Cluster
journal, December 1998

Tudzynski, Bettina; Hölter, Katja
Fungal Genetics and Biology, Vol. 25, Issue 3, p. 157-170
https://doi.org/10.1006/fgbi.1998.1095

Occurrence of Amanita Toxins in American Collections of Deadly Amanitas
journal, June 1966

Tyler, V. E.; Benedict, R. G.; Brady, L. R.
Journal of Pharmaceutical Sciences, Vol. 55, Issue 6, p. 590-593
https://doi.org/10.1002/jps.2600550612

The role of enhancers in the regulation of cell-type-specific transcriptional control
journal, July 1986

Voss, Stephan D.; Schlokat, Uwe; Gruss, Peter
Trends in Biochemical Sciences, Vol. 11, Issue 7, p. 287-289
https://doi.org/10.1016/0968-0004(86)90031-9

Horizontal Gene Transfer and the Evolution of Secondary Metabolite Gene Clusters in Fungi: An Hypothesis
journal, August 2000

Walton, Jonathan D.
Fungal Genetics and Biology, Vol. 30, Issue 3, p. 167-171
https://doi.org/10.1006/fgbi.2000.1224

Ribosomal biosynthesis of the cyclic peptide toxins of Amanita mushrooms
journal, January 2010

Walton, Jonathan D.; Hallen-Adams, Heather E.; Luo, Hong
Biopolymers, Vol. 94, Issue 5, p. 659-664
https://doi.org/10.1002/bip.21416

Molecular phylogenetic studies in the genus Amanita
journal, July 1998

Weiß, Michael; Yang, Zhu-Liang; Oberwinkler, Franz
Canadian Journal of Botany, Vol. 76, Issue 7, p. 1170-1179
https://doi.org/10.1139/b98-129

Characterization of the ferrichrome A biosynthetic gene cluster in the homobasidiomycete Omphalotus olearius
journal, August 2005

Welzel, Kai; Eisfeld, Katrin; Antelo, Luis
FEMS Microbiology Letters, Vol. 249, Issue 1, p. 157-163
https://doi.org/10.1016/j.femsle.2005.06.013

Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate
journal, May 1999

Williams, R. S. B.; Eames, M.; Ryves, W. J.
The EMBO Journal, Vol. 18, Issue 10, p. 2734-2745
https://doi.org/10.1093/emboj/18.10.2734

Pharmacogenetics in model systems: Defining a common mechanism of action for mood stabilisers
journal, July 2005

Williams, Robin S.B.
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 29, Issue 6, p. 1029-1037
https://doi.org/10.1016/j.pnpbp.2005.03.020

A Draft Sequence of the Rice Genome (Oryza sativa L. ssp. indica)
journal, April 2002

Yu, Jun
Science, Vol. 296, Issue 5565, p. 79-92
https://doi.org/10.1126/science.1068037

Production and characterization of Amanitin toxins from a pure culture of Amanita exitialis
journal, November 2005

Zhang, Ping; Chen, ZuoHong; Hu, JinSong
FEMS Microbiology Letters, Vol. 252, Issue 2, p. 223-228
https://doi.org/10.1016/j.femsle.2005.08.049

Process for amplifying, detecting, and/or-cloning nucleic acid sequences
patent, July 1987

Mullis, Kary B.; Erlich, Henry A.; Arnheim, Norman
US Patent Document 4,683,195
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4683195

Process for amplifying nucleic acid sequences
patent, July 1987

Mullis, Kary B.
US Patent Document 4,683,202
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4683202

Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
patent, October 1990

Mullis, Kary B.; Erlich, Henry A.; Gelfand, David H.
US Patent Document 4,965,188
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4965188

Process for direct sequencing during template amplification
patent, July 1999

Koster, Hubert; Van Den Boom, Dirk Johannes; Ruppert, Andreas
US Patent Document 5,928,906
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5928906

Diagnostic Detection of Nucleic Acids
patent-application, August 2001

Urnovitz, Howard B.
US Patent Application 08/943607; 20010014445
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20010014445

Random-primed reverse transcriptase-in vitro transcription method for rna amplification
patent-application, April 2004

Ziman, Michael; Davis, Collen P.
US Patent Application 10/432176; 20040081978
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040081978

Methods for amplifying polymeric nucleic acids
patent-application, November 2005

Behlke, Mark A.; Walder, Joseph A.; Manthey, Jeffrey A.
US Patent Application 10/911652; 20050255486
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050255486

Polymorphic markers and methods of genotyping corn
patent-application, June 2006

Wu, Kunsheng
US Patent Application 11/218305; 20060141495
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060141495

Nucleic Acid Sample Purification and Enrichment with a Thermo-Affinity Microfluidic Sub-Circuit
patent-application, March 2008

Yershov, Gennadiy M.; Kukhtin, Alexander; Chernov, Boris K.
US Patent Application 11/744112; 20080076677
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080076677

Annotated Plant Genes
patent-application, April 2009

Kovalic, David; Liu, Jingdong
US Patent Application 09/684016; 20090093620
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090093620

Identification And Use Of Genes Encoding Amatoxin And Phallotoxin
patent-application, October 2010

Hallen, Heather E.; Scott-Craig, John S.; Walton, Jonathan D.
US Patent Application 12/268229; 20100267019
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100267019

Similar Records in DOE Patents and OSTI.GOV collections:

Use of galerina marginata genes and proteins for peptide production

Patent Hallen-Adams, Heather E.; Scott-Craig, John S.; Walton, Jonathan D.; ...

The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.
Full Text Available
Use of Galerina marginata genes and proteins for peptide production

Patent Hallen-Adams, Heather E.; Scott-Craig, John S.; Walton, Jonathan D.; ...

The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.
Full Text Available
Artificial secretion peptides for heterologous protein production

Patent Debnath, Anik; Church, George

Provided herein, in some embodiments, are artificial secretion peptides capable of directing secretion from Lactobacillus for use, for example, in producing heterologous proteins, including therapeutic proteins.
Full Text Available
Facilitating protein solubility by use of peptide extensions

Patent Freimuth, Paul I; Zhang, Yian-Biao; Howitt, Jason

Expression vectors for expression of a protein or polypeptide of interest as a fusion product composed of the protein or polypeptide of interest fused at one terminus to a solubility enhancing peptide extension are provided. Sequences encoding the peptide extensions are provided. The invention further comprises antibodies which bind specifically to one or more of the solubility enhancing peptide extensions.
Full Text Available
Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus

Patent Dai, Ziyu [Richland, WA]; Lasure, Linda L [Fall City, WA]; Magnuson, Jon K [Pasco, WA]

The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also encompasses a method of utilizing a fungus for protein or chemical production. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to another molecule comprising a coding region of a gene of interest. The gene regulatory element and gene transcription terminator may temporally and spatially regulate expression ofmore » « less
Full Text Available

Similar Records

Title: Use of Galerina marginata genes and proteins for peptide production

Abstract

Citation Formats

An Extended Physical Map of the TOX2 Locus of Cochliobolus carbonum Required for Biosynthesis of HC-Toxin journal, February 2002

Proteins of the ADF/Cofilin Family: Essential Regulators of Actin Dynamics journal, November 1999

Chemical Variation in Amanita journal, July 1981

Suggested functions for prolyl oligopeptidase: A puzzling paradox journal, February 2007

Efficient oxidative folding of conotoxins and the radiation of venomous cone snails journal, October 2003

Structural basis of transcription: α-Amanitin-RNA polymerase II cocrystal at 2.8 Å resolution journal, January 2002

Seamless Proteins Tie Up Their Loose Ends journal, March 2006

WebLogo: A Sequence Logo Generator journal, May 2004

Proline specific peptidases journal, December 1997

Two Enzymes Catalyze the Maturation of a Lasso Peptide in Escherichia coli journal, July 2007

Treatment of Amatoxin Poisoning: 20-Year Retrospective Analysis journal, January 2002

Molecular diversification in spider venoms: A web of combinatorial peptide libraries journal, November 2006

Biosynthesis of Nonribosomal Peptides journal, October 2004

Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease journal, January 2007

The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans journal, July 2004

Prolyl endopeptidases journal, December 2006

Gene expression shifts during perithecium development in Gibberella zeae (anamorph Fusarium graminearum), with particular emphasis on ion transport proteins journal, November 2007

Gene family encoding the major toxins of lethal Amanita mushrooms journal, November 2007

Taxonomy and toxicity of Conocybe lactea and related species journal, August 2003

Fungal secondary metabolism — from biochemistry to genomics journal, December 2005

Size and complexity of the nuclear genome of the ectomycorrhizal fungus Paxillus involutus journal, August 2002

Molecular Characterization and Inhibition of Amanitin Uptake into Human Hepatocytes journal, February 2006

Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin journal, October 1970

Introns are necessary for mRNA accumulation in Schizophyllum commune journal, May 1999

Functional Characterization of Two Cytochrome P450 Monooxygenase Genes, P450-1 and P450-4, of the Gibberellic Acid Gene Cluster in Fusarium proliferatum (Gibberella fujikuroi MP-D) journal, March 2005

Regulation of inducible and tissue-specific gene expression journal, June 1987

Genome sequencing in microfabricated high-density picolitre reactors journal, July 2005

Tryptathionine bridges in peptide synthesis journal, January 2007

Identification of peptide synthetase-encoding genes from filamentous fungi producing host-selective phytotoxins or analogs journal, January 1995

Quorum Sensing in Staphylococci journal, December 2008

Multiple families of peptide synthetase genes from ergopeptine-producing fungi journal, April 1996

Liver transplantation represents the optimal treatment for fulminant hepatic failure from amanita phalloides poisoning journal, April 2006

The prolyl oligopeptidase family journal, February 2002

cDNAs encoding [D-Ala2] deltorphin precursors from skin of Phyllomedusa bicolor also contain genetic information for three dermorphin-related opioid peptides journal, June 1990

Microcin J25 Has a Threaded Sidechain-to-Backbone Ring Structure and Not a Head-to-Tail Cyclized Backbone journal, October 2003

Ab initio Gene Finding in Drosophila Genomic DNA journal, April 2000

Highly-efficient transformation of the homobasidiomycete Schizophyllum commune to phleomycin resistance journal, August 1994

Identification and Analysis of Multivalent Proteolytically Resistant Peptides from Gluten: Implications for Celiac Sprue journal, October 2005

Structural Basis for Gluten Intolerance in Celiac Sprue journal, September 2002

The use of heparin as a simple cost-effective means of controlling background In nudeic acid hybridization procedures journal, January 1984

Substrate- and pH-dependent contribution of oxyanion binding site to the catalysis of prolyl oligopeptidase, a paradigm of the serine oligopeptidase family journal, January 2000

The Noncatalytic β-Propeller Domain of Prolyl Oligopeptidase Enhances the Catalytic Capability of the Peptidase Domain journal, March 2000

Circular proteins — no end in sight journal, March 2002

Xerocomus chrysenteron lectin: identification of a new pesticidal protein journal, June 2003

Characterization of the Final Two Genes of the Gibberellin Biosynthesis Gene Cluster of Gibberella fujikuroi journal, May 2003

Gibberellin Biosynthetic Pathway in Gibberella fujikuroi: Evidence for a Gene Cluster journal, December 1998

Occurrence of Amanita Toxins in American Collections of Deadly Amanitas journal, June 1966

The role of enhancers in the regulation of cell-type-specific transcriptional control journal, July 1986

Horizontal Gene Transfer and the Evolution of Secondary Metabolite Gene Clusters in Fungi: An Hypothesis journal, August 2000

Ribosomal biosynthesis of the cyclic peptide toxins of Amanita mushrooms journal, January 2010

Molecular phylogenetic studies in the genus Amanita journal, July 1998

Characterization of the ferrichrome A biosynthetic gene cluster in the homobasidiomycete Omphalotus olearius journal, August 2005

Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate journal, May 1999

Pharmacogenetics in model systems: Defining a common mechanism of action for mood stabilisers journal, July 2005

A Draft Sequence of the Rice Genome (Oryza sativa L. ssp. indica) journal, April 2002

Production and characterization of Amanitin toxins from a pure culture of Amanita exitialis journal, November 2005

Process for amplifying, detecting, and/or-cloning nucleic acid sequences patent, July 1987

Process for amplifying nucleic acid sequences patent, July 1987

Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme patent, October 1990

Process for direct sequencing during template amplification patent, July 1999

Diagnostic Detection of Nucleic Acids patent-application, August 2001

Random-primed reverse transcriptase-in vitro transcription method for rna amplification patent-application, April 2004

Methods for amplifying polymeric nucleic acids patent-application, November 2005

Polymorphic markers and methods of genotyping corn patent-application, June 2006

Nucleic Acid Sample Purification and Enrichment with a Thermo-Affinity Microfluidic Sub-Circuit patent-application, March 2008

Annotated Plant Genes patent-application, April 2009

Identification And Use Of Genes Encoding Amatoxin And Phallotoxin patent-application, October 2010

An Extended Physical Map of the TOX2 Locus of Cochliobolus carbonum Required for Biosynthesis of HC-Toxin
journal, February 2002

Proteins of the ADF/Cofilin Family: Essential Regulators of Actin Dynamics
journal, November 1999

Chemical Variation in Amanita
journal, July 1981

Suggested functions for prolyl oligopeptidase: A puzzling paradox
journal, February 2007

Efficient oxidative folding of conotoxins and the radiation of venomous cone snails
journal, October 2003

Structural basis of transcription: α-Amanitin-RNA polymerase II cocrystal at 2.8 Å resolution
journal, January 2002

Seamless Proteins Tie Up Their Loose Ends
journal, March 2006

WebLogo: A Sequence Logo Generator
journal, May 2004

Proline specific peptidases
journal, December 1997

Two Enzymes Catalyze the Maturation of a Lasso Peptide in Escherichia coli
journal, July 2007

Treatment of Amatoxin Poisoning: 20-Year Retrospective Analysis
journal, January 2002

Molecular diversification in spider venoms: A web of combinatorial peptide libraries
journal, November 2006

Biosynthesis of Nonribosomal Peptides
journal, October 2004

Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease
journal, January 2007

The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans
journal, July 2004

Prolyl endopeptidases
journal, December 2006

Gene expression shifts during perithecium development in Gibberella zeae (anamorph Fusarium graminearum), with particular emphasis on ion transport proteins
journal, November 2007

Gene family encoding the major toxins of lethal Amanita mushrooms
journal, November 2007

Taxonomy and toxicity of Conocybe lactea and related species
journal, August 2003

Fungal secondary metabolism — from biochemistry to genomics
journal, December 2005

Size and complexity of the nuclear genome of the ectomycorrhizal fungus Paxillus involutus
journal, August 2002

Molecular Characterization and Inhibition of Amanitin Uptake into Human Hepatocytes
journal, February 2006

Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin
journal, October 1970

Introns are necessary for mRNA accumulation in Schizophyllum commune
journal, May 1999

Functional Characterization of Two Cytochrome P450 Monooxygenase Genes, P450-1 and P450-4, of the Gibberellic Acid Gene Cluster in Fusarium proliferatum (Gibberella fujikuroi MP-D)
journal, March 2005

Regulation of inducible and tissue-specific gene expression
journal, June 1987

Genome sequencing in microfabricated high-density picolitre reactors
journal, July 2005

Tryptathionine bridges in peptide synthesis
journal, January 2007

Identification of peptide synthetase-encoding genes from filamentous fungi producing host-selective phytotoxins or analogs
journal, January 1995

Quorum Sensing in Staphylococci
journal, December 2008

Multiple families of peptide synthetase genes from ergopeptine-producing fungi
journal, April 1996

Liver transplantation represents the optimal treatment for fulminant hepatic failure from amanita phalloides poisoning
journal, April 2006

The prolyl oligopeptidase family
journal, February 2002

cDNAs encoding [D-Ala2] deltorphin precursors from skin of Phyllomedusa bicolor also contain genetic information for three dermorphin-related opioid peptides
journal, June 1990

Microcin J25 Has a Threaded Sidechain-to-Backbone Ring Structure and Not a Head-to-Tail Cyclized Backbone
journal, October 2003

Ab initio Gene Finding in Drosophila Genomic DNA
journal, April 2000

Highly-efficient transformation of the homobasidiomycete Schizophyllum commune to phleomycin resistance
journal, August 1994

Identification and Analysis of Multivalent Proteolytically Resistant Peptides from Gluten: Implications for Celiac Sprue
journal, October 2005

Structural Basis for Gluten Intolerance in Celiac Sprue
journal, September 2002

The use of heparin as a simple cost-effective means of controlling background In nudeic acid hybridization procedures
journal, January 1984

Substrate- and pH-dependent contribution of oxyanion binding site to the catalysis of prolyl oligopeptidase, a paradigm of the serine oligopeptidase family
journal, January 2000

The Noncatalytic β-Propeller Domain of Prolyl Oligopeptidase Enhances the Catalytic Capability of the Peptidase Domain
journal, March 2000

Circular proteins — no end in sight
journal, March 2002

Xerocomus chrysenteron lectin: identification of a new pesticidal protein
journal, June 2003

Characterization of the Final Two Genes of the Gibberellin Biosynthesis Gene Cluster of Gibberella fujikuroi
journal, May 2003

Gibberellin Biosynthetic Pathway in Gibberella fujikuroi: Evidence for a Gene Cluster
journal, December 1998

Occurrence of Amanita Toxins in American Collections of Deadly Amanitas
journal, June 1966

The role of enhancers in the regulation of cell-type-specific transcriptional control
journal, July 1986

Horizontal Gene Transfer and the Evolution of Secondary Metabolite Gene Clusters in Fungi: An Hypothesis
journal, August 2000

Ribosomal biosynthesis of the cyclic peptide toxins of Amanita mushrooms
journal, January 2010

Molecular phylogenetic studies in the genus Amanita
journal, July 1998

Characterization of the ferrichrome A biosynthetic gene cluster in the homobasidiomycete Omphalotus olearius
journal, August 2005

Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate
journal, May 1999

Pharmacogenetics in model systems: Defining a common mechanism of action for mood stabilisers
journal, July 2005

A Draft Sequence of the Rice Genome (Oryza sativa L. ssp. indica)
journal, April 2002

Production and characterization of Amanitin toxins from a pure culture of Amanita exitialis
journal, November 2005

Process for amplifying, detecting, and/or-cloning nucleic acid sequences
patent, July 1987

Process for amplifying nucleic acid sequences
patent, July 1987

Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
patent, October 1990

Process for direct sequencing during template amplification
patent, July 1999

Diagnostic Detection of Nucleic Acids
patent-application, August 2001

Random-primed reverse transcriptase-in vitro transcription method for rna amplification
patent-application, April 2004

Methods for amplifying polymeric nucleic acids
patent-application, November 2005

Polymorphic markers and methods of genotyping corn
patent-application, June 2006

Nucleic Acid Sample Purification and Enrichment with a Thermo-Affinity Microfluidic Sub-Circuit
patent-application, March 2008

Annotated Plant Genes
patent-application, April 2009

Identification And Use Of Genes Encoding Amatoxin And Phallotoxin
patent-application, October 2010