Cell-based composite materials with programmed structures and functions
Abstract
The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1241025
- Patent Number(s):
- 9273305
- Application Number:
- 13/869,799
- Assignee:
- Sandia Corporation (Albuquerque, NM)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08K - Use of inorganic or non-macromolecular organic substances as compounding ingredients
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2013 Aug 24
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
. Cell-based composite materials with programmed structures and functions. United States: N. p., 2016.
Web.
. Cell-based composite materials with programmed structures and functions. United States.
. Tue .
"Cell-based composite materials with programmed structures and functions". United States. https://www.osti.gov/servlets/purl/1241025.
@article{osti_1241025,
title = {Cell-based composite materials with programmed structures and functions},
author = {},
abstractNote = {The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 01 00:00:00 EST 2016},
month = {Tue Mar 01 00:00:00 EST 2016}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
A Novel Method for Enzyme Immobilization: Direct Encapsulation of Acid Phosphatase in Nanoporous Silica Host Materials
journal, March 2001
- Wei, Yen; Xu, Jigeng; Feng, Qiuwei
- Journal of Nanoscience and Nanotechnology, Vol. 1, Issue 1, p. 83-93
Cell-Specific Delivery of Diverse Cargos by Bacteriophage MS2 Virus-like Particles
journal, June 2011
- Ashley, Carlee E.; Carnes, Eric C.; Phillips, Genevieve K.
- ACS Nano, Vol. 5, Issue 7, p. 5729-5745
The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers
journal, April 2011
- Ashley, Carlee E.; Carnes, Eric C.; Phillips, Genevieve K.
- Nature Materials, Vol. 10, Issue 5, p. 389-397
Recent bio-applications of sol–gel materials
journal, January 2006
- Avnir, David; Coradin, Thibaud; Lev, Ovadia
- Journal of Materials Chemistry, Vol. 16, Issue 11, p. 1013-1030
Cell-directed-assembly: Directing the formation of nano/bio interfaces and architectures with living cells
journal, March 2011
- Baca, Helen K.; Carnes, Eric C.; Ashley, Carlee E.
- Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1810, Issue 3, p. 259-267
Cell-Directed Assembly of Bio/Nano Interfaces—A New Scheme for Cell Immobilization
journal, September 2007
- Baca, Helen K.; Carnes, Eric; Singh, Seema
- Accounts of Chemical Research, Vol. 40, Issue 9, p. 836-845
Cell-Directed Assembly of Lipid-Silica Nanostructures Providing Extended Cell Viability
journal, July 2006
- Baca, Helen K.; Ashley, Carlee; Carnes, Eric
- Science, Vol. 313, Issue 5785, p. 337-341
Chemical reduction of three-dimensional silica micro-assemblies into microporous silicon replicas
journal, March 2007
- Bao, Zhihao; Weatherspoon, Michael R.; Shian, Samuel
- Nature, Vol. 446, Issue 7132, p. 172-175
Simple and mild preparation of silica-enzyme composites from silicic acid solution
journal, January 2009
- Bassindale, Alan R.; Taylor, Peter G.; Abbate, Vincenzo
- Journal of Materials Chemistry, Vol. 19, Issue 41, p. 7606-7609
A new family of mesoporous molecular sieves prepared with liquid crystal templates
journal, December 1992
- Beck, J. S.; Vartuli, J. C.; Roth, W. J.
- Journal of the American Chemical Society, Vol. 114, Issue 27, p. 10834-10843
Bioinspired enzyme encapsulation for biocatalysis
journal, October 2008
- Betancor, Lorena; Luckarift, Heather R.
- Trends in Biotechnology, Vol. 26, Issue 10, p. 566-572
Aerosol Route to Functional Nanostructured Inorganic and Hybrid Porous Materials
journal, October 2010
- Boissiere, Cedric; Grosso, David; Chaumonnot, Alexandra
- Advanced Materials, Vol. 23, Issue 5, p. 599-623
Drying cells for SEM, AFM and TEM by hexamethyldisilazane: a study on hepatic endothelial cells
journal, April 1997
- Braet, F.; De Zanger, R.; Wisse, E.
- Journal of Microscopy, Vol. 186, Issue 1, p. 84-87
Comparison of hexamethyldisilazane (HMDS), Peldri II, and critical-point drying methods for scanning electron microscopy of biological specimens
journal, December 1993
- Bray, D. F.; Bagu, J.; Koegler, P.
- Microscopy Research and Technique, Vol. 26, Issue 6, p. 489-495
Evaporation-Induced Self-Assembly: Nanostructures Made Easy
journal, May 1999
- Brinker, C. Jeffrey; Lu, Yunfeng; Sellinger, Alan
- Advanced Materials, Vol. 11, Issue 7, p. 579-585
Chitin-Based Organic Networks: An Integral Part of Cell Wall Biosilica in the Diatom Thalassiosira pseudonana
journal, November 2009
- Brunner, Eike; Richthammer, Patrick; Ehrlich, Hermann
- Angewandte Chemie International Edition, Vol. 48, Issue 51, p. 9724-9727
Microparticles with Bimodal Nanoporosity Derived by Microemulsion Templating
journal, December 2009
- Carroll, Nick J.; Pylypenko, Svitlana; Atanassov, Plamen B.
- Langmuir, Vol. 25, Issue 23, p. 13540-13544
Silicatein filaments and subunits from a marine sponge direct the polymerization of silica and silicones in vitro
journal, January 1999
- Cha, J. N.; Shimizu, K.; Zhou, Y.
- Proceedings of the National Academy of Sciences, Vol. 96, Issue 2, p. 361-365
Peptide-Based Methods for the Preparation of Nanostructured Inorganic Materials
journal, February 2010
- Chen, Chun-Long; Rosi, Nathaniel L.
- Angewandte Chemie International Edition, Vol. 49, Issue 11, p. 1924-1942
DNA translocation through an array of kinked nanopores
journal, August 2010
- Chen, Zhu; Jiang, Yingbing; Dunphy, Darren R.
- Nature Materials, Vol. 9, Issue 8, p. 667-675
Interactions of bovine serum albumin and lysozyme with sodium silicate solutions
journal, June 2003
- Coradin, Thibaud; Coupé, Aurélie; Livage, Jacques
- Colloids and Surfaces B: Biointerfaces, Vol. 29, Issue 2-3, p. 189-196
Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord
journal, June 2013
- Dengler, Ellen C.; Liu, Juewen; Kerwin, Audra
- Journal of Controlled Release, Vol. 168, Issue 2, p. 209-224
Protein- and Peptide-Directed Syntheses of Inorganic Materials
journal, November 2008
- Dickerson, Matthew B.; Sandhage, Kenneth H.; Naik, Rajesh R.
- Chemical Reviews, Vol. 108, Issue 11, p. 4935-4978
Bio-Inspired Materials - Mining the Old Literature for New Ideas
journal, September 2010
- Fratzl, Peter; Weiner, Steve
- Advanced Materials, Vol. 22, Issue 41, p. 4547-4550
Biomimetic dual templating of silica by polysaccharide/protein assemblies
journal, August 2008
- Gautier, Clémentine; Abdoul-Aribi, Nora; Roux, Cécile
- Colloids and Surfaces B: Biointerfaces, Vol. 65, Issue 1, p. 140-145
Understanding enzyme immobilisation
journal, January 2009
- Hanefeld, Ulf; Gardossi, Lucia; Magner, Edmond
- Chemical Society Reviews, Vol. 38, Issue 2, p. 453-468
Biocompatible Microfabrication of 3D Isolation Chambers for Targeted Confinement of Individual Cells and Their Progeny
journal, September 2012
- Harper, Jason C.; Brozik, Susan M.; Brinker, C. Jeffrey
- Analytical Chemistry, Vol. 84, Issue 21, p. 8985-8989
Cell-Directed Integration into Three-Dimensional Lipid−Silica Nanostructured Matrices
journal, September 2010
- Harper, Jason C.; Khirpin, Constantine Y.; Carnes, Eric C.
- ACS Nano, Vol. 4, Issue 10, p. 5539-5550
Encapsulation of S. cerevisiae in Poly(glycerol) Silicate Derived Matrices: Effect of Matrix Additives and Cell Metabolic Phase on Long-Term Viability and Rate of Gene Expression
journal, May 2011
- Harper, Jason C.; Lopez, DeAnna M.; Larkin, Elizabeth C.
- Chemistry of Materials, Vol. 23, Issue 10, p. 2555-2564
Orthogonal Cell-Based Biosensing: Fluorescent, Electrochemical, and Colorimetric Detection with Silica-Immobilized Cellular Communities Integrated with an ITO-Glass/Plastic Laminate Cartridge
journal, June 2012
- Harper, Jason C.; Edwards, Thayne L.; Savage, Travis
- Small, Vol. 8, Issue 17, p. 2743-2751
Assembly of large-area, highly ordered, crack-free inverse opal films
journal, May 2010
- Hatton, B.; Mishchenko, L.; Davis, S.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 23, p. 10354-10359
Application of AFM in understanding biomineral formation in diatoms
journal, December 2007
- Hildebrand, Mark; Doktycz, Mitchel J.; Allison, David P.
- Pflügers Archiv - European Journal of Physiology, Vol. 456, Issue 1, p. 127-137
Diatoms, Biomineralization Processes, and Genomics
journal, November 2008
- Hildebrand, Mark
- Chemical Reviews, Vol. 108, Issue 11, p. 4855-4874
Prospects of Manipulating Diatom Silica Nanostructure
journal, January 2005
- Hildebrand, Mark
- Journal of Nanoscience and Nanotechnology, Vol. 5, Issue 1, p. 146-157
Synthesis of Macroporous Minerals with Highly Ordered Three-Dimensional Arrays of Spheroidal Voids
journal, July 1998
- Holland, Brian T.; Blanford, Christopher F.; Stein, Andreas
- Science, Vol. 281, Issue 5376, p. 538-540
Proteins in Mesoporous Silicates
journal, October 2008
- Hudson, Sarah; Cooney, Jakki; Magner, Edmond
- Angewandte Chemie International Edition, Vol. 47, Issue 45, p. 8582-8594
Aerosol-assisted synthesis of monodisperse single-crystalline α-cristobalite nanospheres
journal, January 2012
- Jiang, Xingmao; Bao, Lihong; Cheng, Yung-Sung
- Chemical Communications, Vol. 48, Issue 9, p. 1293-1295
Aerosol fabrication of hollow mesoporous silica nanoparticles and encapsulation of l-methionine as a candidate drug cargo
journal, January 2010
- Jiang, Xingmao; Ward, Timothy L.; Cheng, Yung-Sung
- Chemical Communications, Vol. 46, Issue 17, p. 3019-3021
Hydrothermal synthesis of monodisperse single-crystalline alpha-quartz nanospheres
journal, January 2011
- Jiang, Xingmao; Jiang, Ying-Bing; Brinker, C. Jeffrey
- Chemical Communications, Vol. 47, Issue 26, p. 7524-7526
Photoresponsive Release from Azobenzene-Modified Single Cubic Crystal NaCl/Silica Particles
journal, January 2011
- Jiang, Xingmao; Liu, Nanguo; Assink, Roger A.
- Journal of Nanomaterials, Vol. 2011, p. 1-6
Cellular complexity captured in durable silica biocomposites
journal, October 2012
- Kaehr, B.; Townson, J. L.; Kalinich, R. M.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 43, p. 17336-17341
Protein-Directed Assembly of Arbitrary Three-Dimensional Nanoporous Silica Architectures
journal, January 2011
- Khripin, Constantine Y.; Pristinski, Denis; Dunphy, Darren R.
- ACS Nano, Vol. 5, Issue 2, p. 1401-1409
Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism
journal, October 1992
- Kresge, C. T.; Leonowicz, M. E.; Roth, W. J.
- Nature, Vol. 359, Issue 6397, p. 710-712
Prescribing diatom morphology: toward genetic engineering of biological nanomaterials
journal, December 2007
- Kröger, Nils
- Current Opinion in Chemical Biology, Vol. 11, Issue 6, p. 662-669
Polycationic Peptides from Diatom Biosilica That Direct Silica Nanosphere Formation
journal, November 1999
- Kröger, Nils; Deutzmann, Rainer; Sumper, Manfred
- Science, Vol. 286, Issue 5442, p. 1129-1132
Self-Assembly of Highly Phosphorylated Silaffins and Their Function in Biosilica Morphogenesis
journal, October 2002
- Kröger, Nils; Lorenz, Sonja; Brunner, Eike
- Science, Vol. 298, Issue 5593, p. 584-586
Species-specific polyamines from diatoms control silica morphology
journal, December 2000
- Kroger, N.; Deutzmann, R.; Bergsdorf, C.
- Proceedings of the National Academy of Sciences, Vol. 97, Issue 26, p. 14133-14138
Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery
journal, June 2009
- Liu, Juewen; Jiang, Xingmao; Ashley, Carlee
- Journal of the American Chemical Society, Vol. 131, Issue 22, p. 7567-7569
Porous Nanoparticle Supported Lipid Bilayers (Protocells) as Delivery Vehicles
journal, February 2009
- Liu, Juewen; Stace-Naughton, Alison; Jiang, Xingmao
- Journal of the American Chemical Society, Vol. 131, Issue 4, p. 1354-1355
Diatomaceous Lessons in Nanotechnology and Advanced Materials
journal, August 2009
- Losic, Dusan; Mitchell, James G.; Voelcker, Nicolas H.
- Advanced Materials, Vol. 21, Issue 29, p. 2947-2958
Aerosol-assisted self-assembly of mesostructured spherical nanoparticles
journal, March 1999
- Lu, Yunfeng; Fan, Hongyou; Stump, Aaron
- Nature, Vol. 398, Issue 6724, p. 223-226
Evaporation-Induced Self-Assembly of Hybrid Bridged Silsesquioxane Film and Particulate Mesophases with Integral Organic Functionality
journal, June 2000
- Lu, Yunfeng; Fan, Hongyou; Doke, Nilesh
- Journal of the American Chemical Society, Vol. 122, Issue 22, p. 5258-5261
Synthesis of inorganic materials with complex form
journal, July 1996
- Mann, Stephen; Ozin, Geoffrey A.
- Nature, Vol. 382, Issue 6589, p. 313-318
Encapsulation of cells within silica matrixes: Towards a new advance in the conception of living hybrid materials
journal, February 2010
- Meunier, Christophe F.; Dandoy, Philippe; Su, Bao-Lian
- Journal of Colloid and Interface Science, Vol. 342, Issue 2, p. 211-224
An inorganic–organic proton exchange membrane for fuel cells with a controlled nanoscale pore structure
journal, February 2010
- Moghaddam, Saeed; Pengwang, Eakkachai; Jiang, Ying-Bing
- Nature Nanotechnology, Vol. 5, Issue 3, p. 230-236
Infiltration of Silica Inside Fibrillar Collagen
journal, October 2011
- Niu, Li-na; Jiao, Kai; Qi, Yi-pin
- Angewandte Chemie International Edition, Vol. 50, Issue 49, p. 11688-11691
Biomimetics and Biotemplating of Natural Materials
journal, March 2010
- Paris, Oskar; Burgert, Ingo; Fratzl, Peter
- MRS Bulletin, Vol. 35, Issue 3, p. 219-225
On the role(s) of additives in bioinspired silicification
journal, January 2005
- Patwardhan, Siddharth V.; Clarson, Stephen J.; Perry, Carole C.
- Chemical Communications, Vol. 0, Issue 9, p. 1113-1121
Hierarchical architectures by synergy between dynamical template self-assembly and biomineralization
journal, May 2007
- Pouget, Emilie; Dujardin, Erik; Cavalier, Annie
- Nature Materials, Vol. 6, Issue 6, p. 434-439
Nanopatterned protein microrings from a diatom that direct silica morphogenesis
journal, February 2011
- Scheffel, A.; Poulsen, N.; Shian, S.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 8, p. 3175-3180
Free-standing mesoporous silica films with tunable chiral nematic structures
journal, November 2010
- Shopsowitz, Kevin E.; Qi, Hao; Hamad, Wadood Y.
- Nature, Vol. 468, Issue 7322, p. 422-425
Morphological Control in Colloidal Crystal Templating of Inverse Opals, Hierarchical Structures, and Shaped Particles
journal, February 2008
- Stein, Andreas; Li, Fan; Denny, Nicholas R.
- Chemistry of Materials, Vol. 20, Issue 3, p. 649-666
Extensive and Intimate Association of the Cytoskeleton with Forming Silica in Diatoms: Control over Patterning on the Meso- and Micro-Scale
journal, December 2010
- Tesson, Benoit; Hildebrand, Mark; Sokolov, Igor
- PLoS ONE, Vol. 5, Issue 12, Article No. e14300
Modification of the physical and optical properties of the frustule of the diatom Coscinodiscus wailesii by nickel sulfate
journal, June 2007
- Townley, Helen E.; Woon, Kai Lin; Payne, Frank P.
- Nanotechnology, Vol. 18, Issue 29, Article No. 295101
Organic Templates for the Generation of Inorganic Materials
journal, March 2003
- van Bommel, Kjeld J. C.; Friggeri, Arianna; Shinkai, Seiji
- Angewandte Chemie International Edition, Vol. 42, Issue 9, p. 980-999
Silica replication of the hierarchical structure of wood with nanometer precision
journal, May 2011
- Van Opdenbosch, Daniel; Fritz-Popovski, Gerhard; Paris, Oskar
- Journal of Materials Research, Vol. 26, Issue 10, p. 1193-1202
Bioreactor systems for the production of biopharmaceuticals from animal cells
journal, September 2006
- Warnock, James N.; Al-Rubeai, Mohamed
- Biotechnology and Applied Biochemistry, Vol. 45, Issue 1, p. 1-12
Preparation and Physisorption Characterization of d -Glucose-Templated Mesoporous Silica Sol−Gel Materials
journal, August 1999
- Wei, Yen; Xu, Jigeng; Dong, Hua
- Chemistry of Materials, Vol. 11, Issue 8, p. 2023-2029
Calcium-dependent Clustering of Inositol 1,4,5-Trisphosphate Receptors
journal, June 1998
- Wilson, Bridget S.; Pfeiffer, Janet R.; Smith, Alexander J.
- Molecular Biology of the Cell, Vol. 9, Issue 6, p. 1465-1478
Scale-up analysis for a CHO cell culture process in large-scale bioreactors
journal, July 2009
- Xing, Zizhuo; Kenty, Brian M.; Li, Zheng Jian
- Biotechnology and Bioengineering, Vol. 103, Issue 4, p. 733-746
Composition containing aerogel substrate loaded with tritium
patent, January 1992
- Ashley, Carol S.; Brinker, C. Jeffrey; Ellefson, Robert E.
- US Patent Document 5,078,919
Solid-state radiation-emitting compositions and devices
patent, June 1992
- Ashley, Carol S.; Brinker, C. Jeffrey; Reed, Scott T.
- US Patent Document 5,122,305
Solid-state radiation-emitting compositions and devices
patent, August 1992
- Ashley, Carol S.; Brinker, C. Jeffrey; Reed, Scott T.
- US Patent Document 5,137,659
Molecular sieve sensors for selective detection at the nanogram level
patent, September 1992
- Bein, Thomas W.; Brown, Kelly D.; Frye, Gregory C.
- US Patent Document 5,151,110
Coatings with controlled porosity and chemical properties
patent, July 1993
- Frye, Gregory C.; Brinker, C. Jeffrey; Doughty, Daniel H.
- US Patent Document 5,224,972
Process for making solid-state radiation-emitting composition
patent, August 1993
- Ashley, Carol S.; Brinker, C. Jeffrey; Reed, Scott T.
- US Patent Document 5,240,647
Inorganic volumetric light source excited by ultraviolet light
patent, April 1994
- Reed, Scott T.; Walko, Robert J.; Ashley, Carol S.
- US Patent Document 5,306,445
Luminescent light source for laser pumping and laser system containing same
patent, May 1994
- Hamil, Roy A.; Ashley, Carol S.; Brinker, C. Jeffrey
- US Patent Document 5,313,485
Preparation of high porosity xerogels by chemical surface modification.
patent, October 1996
- Deshpande, Ravindra; Smith, Douglas M.; Brinker, C. Jeffrey
- US Patent Document 5,565,142
Coatings with controlled porosity and chemical properties
patent, December 1996
- Frye, Gregory C.; Brinker, C. Jeffrey; Doughty, Daniel H.
- US Patent Document 5,589,396
Molecular sieving silica membrane fabrication process
patent, June 1998
- Raman, Narayan K.; Brinker, Charles Jeffrey
- US Patent Document 5,770,275
Supported inorganic membranes
patent, June 1998
- Sehgal, Rakesh; Brinker, Charles Jeffrey
- US Patent Document 5,772,735
Process to form mesostructured films
patent, January 1999
- Brinker, C. Jeffrey; Anderson, Mark T.; Ganguli, Rahul
- US Patent Document 5,858,457
Molecular sieving silica membrane fabrication process
patent, August 1999
- Raman, Narayan K.; Brinker, Charles Jeffrey
- US Patent Document 5,935,646
Ambient pressure process for preparing aerogel thin films reliquified sols useful in preparing aerogel thin films
patent, September 1999
- Brinker, Charles Jeffrey; Prakash, Sai
- US Patent Document 5,948,482
Uncooled thin film pyroelectric IR detector with aerogel thermal isolation
patent, September 1999
- Ruffner, Judith A.; Bullington, Jeff; Clem, Paul G.
- US Patent Document 5,949,071
Molecular receptors in metal oxide sol-gel materials prepared via molecular imprinting
patent, May 2000
- Sasaki, Darryl Y.; Brinker, C. Jeffrey; Ashley, Carol S.
- US Patent Document 6,057,377
Method for net-shaping using aerogels
patent, July 2001
- Brinker, C. Jeffrey; Ashey, Carol S.; Reed, Scott T.
- US Patent Document 6,258,305
Self-assembly of nanocomposite materials
patent, July 2001
- Brinker, C. Jeffrey; Sellinger, Alan; Lu, Yunfeng
- US Patent Document 6,264,741
Method for making surfactant-templated, high-porosity thin films
patent, August 2001
- Brinker, C. Jeffrey; Lu, Yunfeng; Fan, Hongyou
- US Patent Document 6,270,846
Method for making surfactant-templated thin films
patent, May 2002
- Brinker, C. Jeffrey; Lu, Yunfeng; Fan, Hongyou
- US Patent Document 6,387,453
Prototyping of patterned functional nanostructures
patent, October 2002
- Fan, Hongyou; Lopez, Gabriel P.; Brinker, Charles Jeffrey
- US Patent Document 6,471,761
Sol-gel method for encapsulating molecules
patent, December 2002
- Brinker, C. Jeffrey; Ashley, Carol S.; Bhatia, Rimple
- US Patent Document 6,495,352
Inorganic dual-layer microporous supported membranes
patent, March 2003
- Brinker, C. Jeffrey; Tsai, Chung-Yi; Lu, Yungfeng
- US Patent Document 6,536,604
Photo-definable self-assembled materials
patent, October 2004
- Doshi, Dhaval A.; Fan, Hongyou; Huesing, Nicola
- US Patent Document 6,808,867
Prototyping of patterned functional nanostructures
patent, July 2005
- Fan, Hongyou; Lopez, Gabriel P.; Brinker, Charles Jeffrey
- US Patent Document 6,913,832
Fluid light guide having hydrophobic aerogel cladding layer
patent, January 2006
- Fraval, Hanafi; Brinker, C. Jeffrey
- US Patent Document 6,983,093
Photo-definable self-assembled materials
patent, February 2008
- Doshi, Dhaval A.; Fan, Hongyou; Huesing, Nicola
- US Patent Document 7,332,264
Preparation of hydrophobic coatings
patent, February 2009
- Branson, Eric D.; Shah, Pratik; Singh, Seema
- US Patent Document 7,485,343
Hollow sphere metal oxides
patent, June 2010
- Jiang, Xingmao; Brinker, Charles Jeffrey
- US Patent Document 7,744,673
Method for making surfactant-templated thin films
patent, August 2010
- Brinker, C. Jeffrey; Lu, Yunfeng; Fan, Hong
- US Patent Document RE41,612
Method of making dense, conformal, ultra-thin cap layers for nanoporous low-k ILD by plasma assisted atomic layer deposition
patent, May 2011
- Jiang, Ying; Cecchi, Joseph L.; Brinker, C. Jeffrey
- US Patent Document 7,947,579
Self-assembly of water-soluble nanocrystals
patent, January 2012
- Fan, Hongyou; Brinker, C. Jeffrey; Lopez, Gabriel P.
- US Patent Document 8,092,595
Ultra-thin microporous/hybrid materials
patent, May 2012
- Jiang, Ying; Cecchi, Joseph L.; Brinker, C. Jeffrey
- US Patent Document 8,187,678
Aerosol method for nano silver-silica composite anti-microbial agent
patent, August 2012
- Jiang, Xingmao; Brinker, C. Jeffrey; Lin, Yong
- US Patent Document 8,246,933
Methods for preparing high crystallinity and surface area porous metal oxides
patent, November 2012
- Jiang, Xingmao; Brinker, C. Jeffrey
- US Patent Document 8,318,127
Freezing assisted fabrication of nano and micro hollow cubic metal oxides
patent, August 2013
- Jiang, Xingmao; Brinker, C. Jeffrey
- US Patent Document 8,501,057
Durable polymer-aerogel based superhydrophobic coatings, a composite material
patent, March 2014
- Kissel, David J.; Brinker, Charles Jeffrey
- US Patent Document 8,663,742
Method of Making Dense, Conformal, Ultra-Thin Cap Layers for Nanoporous Low-K ILD by Plasma Assisted Atomic Layer Deposition
patent-application, August 2011
- Jiang, Ying-Bing; Cecchi, Joseph L.; Brinker, C. Jeffrey
- US Patent Document 13/083790; 20110186971
Porous Nanoparticle Supported Lipid Bilayer Nanostructures
patent-application, November 2011
- Liu, Juewen; Brinker, Jeffrey C.; Ashley, Carlee
- US Patent Document 13/143164; 20110268791
Superhydrophobic Aerogel That Does Not Require Per-Fluoro Compounds or Contain Any Fluorine
patent-application, February 2012
- Kissel, David J.; Brinker, Charles Jeffrey
- US Patent Document 13/121166; 20120040577