L-malate production by metabolically engineered escherichia coli

Zhang, Xueli; Wang, Xuan; Shanmugam, Keelnatham T.; Ingram, Lonnie O'Neal

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Title: L-malate production by metabolically engineered escherichia coli

Abstract

A process for the production of malic acid in commercially significant quantities from the carbon compounds by genetically modified bacterial strains (GMBS; also referred to as biocatalysts or genetically modified microorganisms) is disclosed. Microorganisms suitable for the production of malic acid can be cultured in one or two-step processes as disclosed herein.

Inventors:: Zhang, Xueli; Wang, Xuan; Shanmugam, Keelnatham T.; Ingram, Lonnie O'Neal

Issue Date:: Tue Nov 17 00:00:00 EST 2015

Research Org.:: Univ. of Florida, Gainesville, FL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1226538

Patent Number(s):: 9187772

Application Number:: 13/819,773

Assignee:: University of Florida Research Foundation, Inc. (Gainesville, FL)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

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C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N1/20 - Bacteria {
C12N9/001 - {acting on the CH-CH group of donors
C12N9/88 - Lyases

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C12P7/42 - Hydroxy-carboxylic acids
C12P7/46 - Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
C12Y103/01006 - Fumarate reductase
C12Y401/01031 - Phosphoenolpyruvate carboxylase

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DOE Contract Number:: FG36-08GO88142

Resource Type:: Patent

Resource Relation:: Patent File Date: 2011 Sep 01

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Zhang, Xueli, Wang, Xuan, Shanmugam, Keelnatham T., and Ingram, Lonnie O'Neal. L-malate production by metabolically engineered escherichia coli.  United States: N. p., 2015. 
        Web.

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                    Zhang, Xueli, Wang, Xuan, Shanmugam, Keelnatham T., & Ingram, Lonnie O'Neal. L-malate production by metabolically engineered escherichia coli.  United States.

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                    Zhang, Xueli, Wang, Xuan, Shanmugam, Keelnatham T., and Ingram, Lonnie O'Neal. Tue .  
        "L-malate production by metabolically engineered escherichia coli".  United States.  https://www.osti.gov/servlets/purl/1226538.

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@article{osti_1226538,

  title        = {L-malate production by metabolically engineered escherichia coli},

  author       = {Zhang, Xueli and Wang, Xuan and Shanmugam, Keelnatham T. and Ingram, Lonnie O'Neal},

  abstractNote = {A process for the production of malic acid in commercially significant quantities from the carbon compounds by genetically modified bacterial strains (GMBS; also referred to as biocatalysts or genetically modified microorganisms) is disclosed. Microorganisms suitable for the production of malic acid can be cultured in one or two-step processes as disclosed herein.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Nov 17 00:00:00 EST 2015},

  month        = {Tue Nov 17 00:00:00 EST 2015}

}

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Works referenced in this record:

Materials and Methods for Efficient Succinate and Malate Production
patent-application, July 2010

Jantama, Kaemwich; Haupt, Mark John; Zhang, Xueli
US Patent Application 12/529826; 20100184171
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100184171

Organic Acid Production by Fungal Cells
patent-application, February 2011

Winkler, Aaron Adriaan; De Hulster, Abraham Frederik; Van Dijken, Johannes Pieter
US Patent Application 12/600559; 20110039327
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110039327

Engineering the pathway for succinate production
patent-application, March 2012

Zhang, Xueli; Jantama, Kaemwich; Moore, Jonathan C.
US Patent Application 13/256460; 20120058530
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120058530

Enhanced hydrogen production from glucose using ldh- and frd-inactivated Escherichia coli strains
journal, May 2006

Yoshida, Akihito; Nishimura, Taku; Kawaguchi, Hideo
Applied Microbiology and Biotechnology, Vol. 73, Issue 1
https://doi.org/10.1007/s00253-006-0456-9

Sugar transporters in efficient utilization of mixed sugar substrates: current knowledge and outlook
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Jojima, Toru; Omumasaba, Crispinus A.; Inui, Masayuki
Applied Microbiology and Biotechnology, Vol. 85, Issue 3
https://doi.org/10.1007/s00253-009-2292-1

Metabolically engineered Escherichia coli for biotechnological production of four-carbon 1,4-dicarboxylic acids
journal, November 2010

Cao, Yujin; Cao, Yugang; Lin, Xiangzhi
Journal of Industrial Microbiology & Biotechnology, Vol. 38, Issue 6
https://doi.org/10.1007/s10295-010-0913-4

Fermentation of Glycerol to Succinate by Metabolically Engineered Strains of Escherichia coli
journal, February 2010

Zhang, X.; Shanmugam, K. T.; Ingram, L. O.
Applied and Environmental Microbiology, Vol. 76, Issue 8
https://doi.org/10.1128/AEM.02902-09