Engineering microbes for efficient production of chemicals
Abstract
This present invention relates to production of chemicals from microorganisms that have been genetically engineered and metabolically evolved. Improvements in chemical production have been established, and particular mutations that lead to those improvements have been identified. Specific examples are given in the identification of mutations that occurred during the metabolic evolution of a bacterial strain genetically engineered to produce succinic acid. This present invention also provides a method for evaluating the industrial applicability of mutations that were selected during the metabolic evolution for increased succinic acid production. This present invention further provides microorganisms engineered to have mutations that are selected during metabolic evolution and contribute to improved production of succinic acid, other organic acids and other chemicals of commercial interest.
- Inventors:
- Issue Date:
- Research Org.:
- Myriant Corporation, Quincy, MA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1178677
- Patent Number(s):
- 9017976
- Application Number:
- 13/503,999
- Assignee:
- Myriant Corporation (Quincy, MA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
B - PERFORMING OPERATIONS B29 - WORKING OF PLASTICS B29C - SHAPING OR JOINING OF PLASTICS
- DOE Contract Number:
- EE0002878
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2010 Nov 17
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 54 ENVIRONMENTAL SCIENCES
Citation Formats
Gong, Wei, Dole, Sudhanshu, Grabar, Tammy, Collard, Andrew Christopher, Pero, Janice G, and Yocum, R Rogers. Engineering microbes for efficient production of chemicals. United States: N. p., 2015.
Web.
Gong, Wei, Dole, Sudhanshu, Grabar, Tammy, Collard, Andrew Christopher, Pero, Janice G, & Yocum, R Rogers. Engineering microbes for efficient production of chemicals. United States.
Gong, Wei, Dole, Sudhanshu, Grabar, Tammy, Collard, Andrew Christopher, Pero, Janice G, and Yocum, R Rogers. Tue .
"Engineering microbes for efficient production of chemicals". United States. https://www.osti.gov/servlets/purl/1178677.
@article{osti_1178677,
title = {Engineering microbes for efficient production of chemicals},
author = {Gong, Wei and Dole, Sudhanshu and Grabar, Tammy and Collard, Andrew Christopher and Pero, Janice G and Yocum, R Rogers},
abstractNote = {This present invention relates to production of chemicals from microorganisms that have been genetically engineered and metabolically evolved. Improvements in chemical production have been established, and particular mutations that lead to those improvements have been identified. Specific examples are given in the identification of mutations that occurred during the metabolic evolution of a bacterial strain genetically engineered to produce succinic acid. This present invention also provides a method for evaluating the industrial applicability of mutations that were selected during the metabolic evolution for increased succinic acid production. This present invention further provides microorganisms engineered to have mutations that are selected during metabolic evolution and contribute to improved production of succinic acid, other organic acids and other chemicals of commercial interest.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 28 00:00:00 EDT 2015},
month = {Tue Apr 28 00:00:00 EDT 2015}
}
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