Title: Phthalamide-lanthanide complexes for use as luminescent markers

Abstract

The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.

Inventors:

Raymond, Kenneth N.; Petoud, Stephane; Cohen, Seth M.; Xu, Jide

Issue Date:

Tue Mar 08 00:00:00 EST 2005

Research Org.:

Univ. of California, Oakland, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1175260

Patent Number(s):

6864103

Application Number:

09/992,156

Assignee:

The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K41/0057 - {Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light
A61K49/0002 - {General or multifunctional contrast agents, e.g. chelated agents}
A61K49/0019 - {characterised by the fluorescent group}
A61K49/103 - {the complex-forming compound being acyclic, e.g. DTPA}
A61K49/106 - {the complex-forming compound being cyclic, e.g. DOTA}
A61K49/122 - {dimers of complexes or complex-forming compounds}
A61K49/124 - {dendrimers, dendrons, hyperbranched compounds}
A61K51/0478 - {complexes from non-cyclic ligands, e.g. EDTA, MAG3}
A61K51/0482 - {chelates from cyclic ligands, e.g. DOTA}
A61K51/06 - Macromolecular compounds {, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C235/60 - having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS

C07D487/08 - Bridged systems
C07D487/18 - Bridged systems
C07D487/22 - in which the condensed system contains four or more hetero rings

C - CHEMISTRY C09 - DYES C09K - MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE

C09K11/06 - containing organic luminescent materials
C09K2211/1007 - Non-condensed systems
C09K2211/182 - of the rare earth metals, i.e. Sc, Y or lanthanide

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/37 - involving peptidase or proteinase

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N2458/40 - Rare earth chelates
G01N33/582 - {with fluorescent label}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S436/80 - Fluorescent dyes, e.g. rhodamine
Y10S436/804 - Radioisotope, e.g. radioimmunoassay

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DOE Contract Number:  

AC0376F00098

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY