Piperazine-based nucleic acid analogs
Abstract
A novel nucleoside analog is disclosed which comprises a piperazine ring in the place of the ring ribose or deoxyribose sugar. Monomers utilizing a broad variety of nucleobases are disclosed, as well as oligomers comprising the monomers disclosed herein linked by a variety of linkages, including amide, phosphonamide, and sulfonamide linkages. A method of synthesizing the nucleoside analogs is also disclosed.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California, Oakland, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175200
- Patent Number(s):
- 6841675
- Application Number:
- 10/171,073
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Schmidt, Jurgen, Silks, Louis A., and Michalczyk, Ryszard. Piperazine-based nucleic acid analogs. United States: N. p., 2005.
Web.
Schmidt, Jurgen, Silks, Louis A., & Michalczyk, Ryszard. Piperazine-based nucleic acid analogs. United States.
Schmidt, Jurgen, Silks, Louis A., and Michalczyk, Ryszard. Tue .
"Piperazine-based nucleic acid analogs". United States. https://www.osti.gov/servlets/purl/1175200.
@article{osti_1175200,
title = {Piperazine-based nucleic acid analogs},
author = {Schmidt, Jurgen and Silks, Louis A. and Michalczyk, Ryszard},
abstractNote = {A novel nucleoside analog is disclosed which comprises a piperazine ring in the place of the ring ribose or deoxyribose sugar. Monomers utilizing a broad variety of nucleobases are disclosed, as well as oligomers comprising the monomers disclosed herein linked by a variety of linkages, including amide, phosphonamide, and sulfonamide linkages. A method of synthesizing the nucleoside analogs is also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 11 00:00:00 EST 2005},
month = {Tue Jan 11 00:00:00 EST 2005}
}
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