Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
Abstract
A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source.
- Inventors:
- Issue Date:
- Research Org.:
- Idaho National Laboratory (INL), Idaho Falls, ID (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1171695
- Patent Number(s):
- 8969009
- Application Number:
- 12/586,109
- Assignee:
- IDO
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC07-05ID14517
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2009 Sep 17
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Thompson, Vicki S, Lacey, Jeffrey A, Gentillon, Cynthia A, and Apel, William A. Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual. United States: N. p., 2015.
Web.
Thompson, Vicki S, Lacey, Jeffrey A, Gentillon, Cynthia A, & Apel, William A. Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual. United States.
Thompson, Vicki S, Lacey, Jeffrey A, Gentillon, Cynthia A, and Apel, William A. Tue .
"Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual". United States. https://www.osti.gov/servlets/purl/1171695.
@article{osti_1171695,
title = {Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual},
author = {Thompson, Vicki S and Lacey, Jeffrey A and Gentillon, Cynthia A and Apel, William A},
abstractNote = {A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 03 00:00:00 EST 2015},
month = {Tue Mar 03 00:00:00 EST 2015}
}
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Works referencing / citing this record:
Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
patent, August 2016
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