Devices, systems, and methods for conducting sandwich assays using sedimentation
Abstract
Embodiments of the present invention are directed toward devices, systems, and method for conducting sandwich assays using sedimentation. In one example, a method includes generating complexes on a plurality of beads in a fluid sample, individual ones of the complexes comprising a capture agent, a target analyte, and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1169095
- Patent Number(s):
- 8945914
- Application Number:
- 12/891,977
- Assignee:
- Sandia Corporation (Albuquerque, NM)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 42 ENGINEERING
Citation Formats
Schaff, Ulrich Y, Sommer, Gregory J, Singh, Anup K, and Hatch, Anson V. Devices, systems, and methods for conducting sandwich assays using sedimentation. United States: N. p., 2015.
Web.
Schaff, Ulrich Y, Sommer, Gregory J, Singh, Anup K, & Hatch, Anson V. Devices, systems, and methods for conducting sandwich assays using sedimentation. United States.
Schaff, Ulrich Y, Sommer, Gregory J, Singh, Anup K, and Hatch, Anson V. Tue .
"Devices, systems, and methods for conducting sandwich assays using sedimentation". United States. https://www.osti.gov/servlets/purl/1169095.
@article{osti_1169095,
title = {Devices, systems, and methods for conducting sandwich assays using sedimentation},
author = {Schaff, Ulrich Y and Sommer, Gregory J and Singh, Anup K and Hatch, Anson V},
abstractNote = {Embodiments of the present invention are directed toward devices, systems, and method for conducting sandwich assays using sedimentation. In one example, a method includes generating complexes on a plurality of beads in a fluid sample, individual ones of the complexes comprising a capture agent, a target analyte, and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 03 00:00:00 EST 2015},
month = {Tue Feb 03 00:00:00 EST 2015}
}
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