Dielectrokinetic chromatography devices

Chirica, Gabriela S; Fiechtner, Gregory J; Singh, Anup K

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Title: Dielectrokinetic chromatography devices

Abstract

Disclosed herein are methods and devices for dielectrokinetic chromatography. As disclosed, the devices comprise microchannels having at least one perturber which produces a non-uniformity in a field spanning the width of the microchannel. The interaction of the field non-uniformity with a perturber produces a secondary flow which competes with a primary flow. By decreasing the size of the perturber the secondary flow becomes significant for particles/analytes in the nanometer-size range. Depending on the nature of a particle/analyte present in the fluid and its interaction with the primary flow and the secondary flow, the analyte may be retained or redirected. The composition of the primary flow can be varied to affect the magnitude of primary and/or secondary flows on the particles/analytes and thereby separate and concentrate it from other particles/analytes.

Inventors:: Chirica, Gabriela S; Fiechtner, Gregory J; Singh, Anup K

Issue Date:: Tue Dec 16 00:00:00 EST 2014

Research Org.:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1165448

Patent Number(s):: 8911606

Application Number:: 14/050,502

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

Show more

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D15/08 - Selective adsorption, e.g. chromatography
B01D15/1878 - {for multi-dimensional chromatography}
B01D15/3861 - {using an external stimulus}
B01D63/00 - Apparatus in general for separation processes using semi-permeable membranes

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N27/44791 - {Microapparatus
G01N30/0005 - {Field flow fractionation}
G01N33/569 - for microorganisms, e.g. protozoa, bacteria, viruses

Show less

DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Resource Relation:: Patent File Date: 2013 Oct 10

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

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                    Chirica, Gabriela S, Fiechtner, Gregory J, and Singh, Anup K. Dielectrokinetic chromatography devices.  United States: N. p., 2014. 
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                    Chirica, Gabriela S, Fiechtner, Gregory J, & Singh, Anup K. Dielectrokinetic chromatography devices.  United States.

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                    Chirica, Gabriela S, Fiechtner, Gregory J, and Singh, Anup K. Tue .  
        "Dielectrokinetic chromatography devices".  United States.  https://www.osti.gov/servlets/purl/1165448.

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@article{osti_1165448,

  title        = {Dielectrokinetic chromatography devices},

  author       = {Chirica, Gabriela S and Fiechtner, Gregory J and Singh, Anup K},

  abstractNote = {Disclosed herein are methods and devices for dielectrokinetic chromatography. As disclosed, the devices comprise microchannels having at least one perturber which produces a non-uniformity in a field spanning the width of the microchannel. The interaction of the field non-uniformity with a perturber produces a secondary flow which competes with a primary flow. By decreasing the size of the perturber the secondary flow becomes significant for particles/analytes in the nanometer-size range. Depending on the nature of a particle/analyte present in the fluid and its interaction with the primary flow and the secondary flow, the analyte may be retained or redirected. The composition of the primary flow can be varied to affect the magnitude of primary and/or secondary flows on the particles/analytes and thereby separate and concentrate it from other particles/analytes.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Dec 16 00:00:00 EST 2014},

  month        = {Tue Dec 16 00:00:00 EST 2014}

}

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Dielectrokinetic chromatography and devices thereof

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Disclosed herein are methods and devices for dielectrokinetic chromatography. As disclosed, the devices comprise microchannels having at least one perturber which produces a non-uniformity in a field spanning the width of the microchannel. The interaction of the field non-uniformity with a perturber produces a secondary flow which competes with a primary flow. By decreasing the size of the perturber the secondary flow becomes significant for particles/analytes in the nanometer-size range. Depending on the nature of a particle/analyte present in the fluid and its interaction with the primary flow and the secondary flow, the analyte may be retained or redirected. Themore » « less
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Chromatography devices and methods

Patent Granick, Steve; Hong, Liang

Provided are chromatography devices having a stationary phase that includes patchy particles having at least two different surface chemistries, such as Janus particles. Also provided are methods of separating at least one analyte out of a sample, where the method includes adding a sample having at least one analyte to a chromatography device that includes a stationary phase that includes a plurality of patchy particles. Further provided are methods that include packing a chromatography column with a plurality patchy particles having at least two different surface chemistries. Additional embodiments are disclosed.
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Device to improve detection in electro-chromatography

Patent Garguilo, Michael G [Livermore, CA]; Paul, Phillip H [Livermore, CA]; Rakestraw, David J [Fremont, CA]

Apparatus and method for improving the resolution of non-pressure driven capillary chromatographic systems, and particularly for capillary electrochromatography (CEC) systems. By reducing the cross-sectional area of a packed capillary column by means of a second open capillary contiguous with the outlet end of a packed capillary column, where the packed capillary column has a cross sectional area of between about 2 and 5 times that of the open capillary column, the phenomenon of band broadening in the transition region between the open capillary and the packed capillary column, where the individual components of the mixture are analyzed, can be eliminated,more » « less
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Device to improve detection in electro-chromatography

Patent Garguilo, Michael G [Livermore, CA]; Paul, Phillip H [Livermore, CA]; Rakestraw, David J [Fremont, CA]

Apparatus and method for improving the resolution of non-pressure driven capillary chromatographic systems, and particularly for capillary electrochromatography (CEC) systems. By reducing the cross-sectional area of a packed capillary column by means of a second open capillary contiguous with the outlet end of a packed capillary column, where the packed capillary column has a cross sectional area of between about 2 and 5 times that of the open capillary column, the phenomenon of band broadening in the transition region between the open capillary and the packed capillary column, where the individual components of the mixture are analyzed, can be eliminated,more » « less
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Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging

Patent Wang, Daojing; Mao, Pan; Gomez-Sjoberg, Rafael; ...

Systems, methods, and apparatus provide integration of microscopic imaging and liquid chromatography-mass spectrometry on a microfluidic device. In one aspect, an apparatus includes a first wafer, a second wafer, and an emitter. The emitter is disposed between the first wafer and the second wafer. The first wafer defines a sample input hole. The first wafer and the second wafer define a first channel, the first channel including a first end and a second end. The first end of the first channel is proximate the sample input hole. The first channel is configured to contain separation media. The second end ofmore » « less
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Title: Dielectrokinetic chromatography devices

Abstract

Citation Formats

Apparatus for continuous electrochromatographic separation patent, February 1982

Polyether-polycarbonates for dialysis membranes patent, January 1986

Disposable electromanipulation chamber patent, July 1989

Coiled filter strip with upstream and downstream butt ends patent, May 1994

Filtration using ionically and electrically conductive depth filter patent, December 1994

Microlithographic array for macromolecule and cell fractionation patent, June 1995

Method of continuously separating mixtures of microscopic dielectric particles and apparatus for carrying through this method patent, October 1995

Chip for performing an electrophoretic separation of molecules and method using same patent, July 2001

Methods of analysis/separation patent, October 2001

Electrokinetic concentration of charged molecules patent, August 2002

Fibrous absorbent material and methods of making the same patent, August 2003

Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation patent, November 2003

Electrode-less dielectrophorises for polarizable particles patent, November 2004

Piecewise uniform conduction-like flow channels and method therefor patent, February 2006

Dielectrophoretic systems without embedded electrodes patent, March 2006

Continuous flow dielectrophoretic particle concentrator patent, April 2007

Dialysis on microchips using thin porous polymer membranes patent, September 2007

Planar micromixer patent, March 2008

Dielectrophoresis device and method having insulating ridges for manipulating particles patent, March 2008

Dielectrophoresis device and method having non-uniform arrays for manipulating particles patent, September 2008

Protein detection system patent, May 2009

Method for dialysis on microchips using thin porous polymer membrane patent, May 2009

Apparatus and method for concentrating and filtering particles suspended in a fluid patent, May 2009

Portable modular detection system patent, October 2009

Methods and devices for high-throughput dielectrophoretic concentration patent, February 2010

Insulator-based DEP with impedance measurements for analyte detection patent, March 2010

Dielectrophoretic columnar focusing device patent, May 2010

Dialysis membrane for separation on microchips patent, July 2010

Concentration and separation of biological organisms by ultrafiltration and dielectrophoresis patent, October 2010

Preconcentration and separation of analytes in microchannels patent, November 2010

System for concentrating and analyzing particles suspended in a fluid patent, April 2011

Microfluidic devices and methods for integrated flow cytometry patent, August 2011

Method for forming polymerized microfluidic devices patent, November 2011

Method for voltage-gated protein fractionation patent, April 2012

Method for concentration and separation of biological organisms by ultrafiltration and dielectrophoresis patent, September 2012

Dielectrophoresis device and method having nonuniform arrays for manipulating particles patent, September 2012

Microfluidic device having an immobilized pH gradient and PAGE gels for protein separation and analysis patent, December 2012

Method for forming polymerized microfluidic devices patent, March 2013

Multidimensional bioseparation with modular microfluidics patent, August 2013

Microchannel gel electrophoretic separation systems and methods for preparing and using patent, September 2013

Dielectrokinetic chromatography and devices thereof patent, April 2014

Microfluidic devices and methods including porous polymer monoliths patent, April 2014

Microfluidic device having an immobilized pH gradient and page gels for protein separation and analysis patent, May 2014

Device and method for the manipulation of a fluid sample patent-application, November 2002

Continuous flow dielectrophoretic particle concentrator patent-application, January 2003

Acute treatment of headache with phenothiazine antipsychotics patent-application, May 2004

Variable flow control apparatus patent-application, June 2004

Multidimensional electrophoresis and methods of making and using thereof patent-application, June 2004

Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields patent-application, July 2004

Frit material and bonding method for microfluidic separation devices patent-application, January 2005

Microfluidic devices comprising biochannels patent-application, January 2005

Microliter scale solid phase extraction devices patent-application, July 2006

Cell separation method using hydrophobic solid supports patent-application, October 2006

Coherent nonlinear chromatography and methods and devices thereof patent-application, April 2007

Coupling for conduits sealed in a recess of a housing patent-application, June 2007

Multi-Analyte Analysis of Saliva Biomarkers as Predictors of Periodontal and Pre-Implant Disease patent-application, August 2010

Determination of Cell Viability in Single or Mixed Samples Using Capillary Electrophoresis Laser-Induced Fluorescence Microfluidic Systems journal, October 2001

Separating Microbes in the Manner of Molecules. 1. Capillary Electrokinetic Approaches journal, December 1999

Fabrication of microstructures with high aspect ratios and great structural heights by synchrotron radiation lithography, galvanoforming, and plastic moulding (LIGA process) journal, May 1986

Planar quartz chips with submicron channels for two-dimensional capillary electrophoresis applications journal, March 1998

Silicate entrapped columns — new columns designed for capillary electrochromatography journal, January 1999

Size Exclusion Chromatography of Microliter Volumes for On-Line Use in Low-Pressure Microfluidic Systems journal, August 2006

A simple procedure for the preparation of fritless columns by entrapping conventional high performance liquid chromatography sorbents journal, September 2000

Fritless Capillary Columns for HPLC and CEC Prepared by Immobilizing the Stationary Phase in an Organic Polymer Matrix journal, August 2000

Novel monolithic columns with templated porosity journal, July 2001

Sorting by diffusion: An asymmetric obstacle course for continuous molecular separation journal, November 1999

Dielectrophoresis in Microchips Containing Arrays of Insulating Posts: Theoretical and Experimental Results journal, September 2003

Streaming dielectrophoresis for continuous-flow microfluidic devices journal, November 2003

Microfluidic Cell Separation by 2-dimensional Dielectrophoresis journal, January 1999

Starburst dendrimers as macromolecular pore-templates for stationary phases in capillary chromatography journal, November 2002

Separation of Long DNA Molecules in a Microfabricated Entropic Trap Array journal, May 2000

A DNA prism for high-speed continuous fractionation of large DNA molecules journal, September 2002

Planar dielectrochromatography on non-wetted thin layers journal, August 2001

Dielectrophoretic Concentration and Separation of Live and Dead Bacteria in an Array of Insulators journal, March 2004

Insulator-based dielectrophoresis for the selective concentration and separation of live bacteria in water journal, June 2004

High-intensity, high-gradient electric separation and dielectric filtration of particulate and granular materials journal, December 1982

Dielectrophoretic chromatography with cross-flow injection conference, January 2002

Apparatus for continuous electrochromatographic separation
patent, February 1982

Polyether-polycarbonates for dialysis membranes
patent, January 1986

Disposable electromanipulation chamber
patent, July 1989

Coiled filter strip with upstream and downstream butt ends
patent, May 1994

Filtration using ionically and electrically conductive depth filter
patent, December 1994

Microlithographic array for macromolecule and cell fractionation
patent, June 1995

Method of continuously separating mixtures of microscopic dielectric particles and apparatus for carrying through this method
patent, October 1995

Chip for performing an electrophoretic separation of molecules and method using same
patent, July 2001

Methods of analysis/separation
patent, October 2001

Electrokinetic concentration of charged molecules
patent, August 2002

Fibrous absorbent material and methods of making the same
patent, August 2003

Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
patent, November 2003

Electrode-less dielectrophorises for polarizable particles
patent, November 2004

Piecewise uniform conduction-like flow channels and method therefor
patent, February 2006

Dielectrophoretic systems without embedded electrodes
patent, March 2006

Continuous flow dielectrophoretic particle concentrator
patent, April 2007

Dialysis on microchips using thin porous polymer membranes
patent, September 2007

Planar micromixer
patent, March 2008

Dielectrophoresis device and method having insulating ridges for manipulating particles
patent, March 2008

Dielectrophoresis device and method having non-uniform arrays for manipulating particles
patent, September 2008

Protein detection system
patent, May 2009

Method for dialysis on microchips using thin porous polymer membrane
patent, May 2009

Apparatus and method for concentrating and filtering particles suspended in a fluid
patent, May 2009

Portable modular detection system
patent, October 2009

Methods and devices for high-throughput dielectrophoretic concentration
patent, February 2010

Insulator-based DEP with impedance measurements for analyte detection
patent, March 2010

Dielectrophoretic columnar focusing device
patent, May 2010

Dialysis membrane for separation on microchips
patent, July 2010

Concentration and separation of biological organisms by ultrafiltration and dielectrophoresis
patent, October 2010

Preconcentration and separation of analytes in microchannels
patent, November 2010

System for concentrating and analyzing particles suspended in a fluid
patent, April 2011

Microfluidic devices and methods for integrated flow cytometry
patent, August 2011

Method for forming polymerized microfluidic devices
patent, November 2011

Method for voltage-gated protein fractionation
patent, April 2012

Method for concentration and separation of biological organisms by ultrafiltration and dielectrophoresis
patent, September 2012

Dielectrophoresis device and method having nonuniform arrays for manipulating particles
patent, September 2012

Microfluidic device having an immobilized pH gradient and PAGE gels for protein separation and analysis
patent, December 2012

Method for forming polymerized microfluidic devices
patent, March 2013

Multidimensional bioseparation with modular microfluidics
patent, August 2013

Microchannel gel electrophoretic separation systems and methods for preparing and using
patent, September 2013

Dielectrokinetic chromatography and devices thereof
patent, April 2014

Microfluidic devices and methods including porous polymer monoliths
patent, April 2014

Microfluidic device having an immobilized pH gradient and page gels for protein separation and analysis
patent, May 2014

Device and method for the manipulation of a fluid sample
patent-application, November 2002

Continuous flow dielectrophoretic particle concentrator
patent-application, January 2003

Acute treatment of headache with phenothiazine antipsychotics
patent-application, May 2004

Variable flow control apparatus
patent-application, June 2004

Multidimensional electrophoresis and methods of making and using thereof
patent-application, June 2004

Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields
patent-application, July 2004

Frit material and bonding method for microfluidic separation devices
patent-application, January 2005

Microfluidic devices comprising biochannels
patent-application, January 2005

Microliter scale solid phase extraction devices
patent-application, July 2006

Cell separation method using hydrophobic solid supports
patent-application, October 2006

Coherent nonlinear chromatography and methods and devices thereof
patent-application, April 2007

Coupling for conduits sealed in a recess of a housing
patent-application, June 2007

Multi-Analyte Analysis of Saliva Biomarkers as Predictors of Periodontal and Pre-Implant Disease
patent-application, August 2010

Determination of Cell Viability in Single or Mixed Samples Using Capillary Electrophoresis Laser-Induced Fluorescence Microfluidic Systems
journal, October 2001

Separating Microbes in the Manner of Molecules. 1. Capillary Electrokinetic Approaches
journal, December 1999

Fabrication of microstructures with high aspect ratios and great structural heights by synchrotron radiation lithography, galvanoforming, and plastic moulding (LIGA process)
journal, May 1986

Planar quartz chips with submicron channels for two-dimensional capillary electrophoresis applications
journal, March 1998

Silicate entrapped columns — new columns designed for capillary electrochromatography
journal, January 1999

Size Exclusion Chromatography of Microliter Volumes for On-Line Use in Low-Pressure Microfluidic Systems
journal, August 2006

A simple procedure for the preparation of fritless columns by entrapping conventional high performance liquid chromatography sorbents
journal, September 2000

Fritless Capillary Columns for HPLC and CEC Prepared by Immobilizing the Stationary Phase in an Organic Polymer Matrix
journal, August 2000

Novel monolithic columns with templated porosity
journal, July 2001

Sorting by diffusion: An asymmetric obstacle course for continuous molecular separation
journal, November 1999

Dielectrophoresis in Microchips Containing Arrays of Insulating Posts: Theoretical and Experimental Results
journal, September 2003

Streaming dielectrophoresis for continuous-flow microfluidic devices
journal, November 2003

Microfluidic Cell Separation by 2-dimensional Dielectrophoresis
journal, January 1999

Starburst dendrimers as macromolecular pore-templates for stationary phases in capillary chromatography
journal, November 2002

Separation of Long DNA Molecules in a Microfabricated Entropic Trap Array
journal, May 2000

A DNA prism for high-speed continuous fractionation of large DNA molecules
journal, September 2002

Planar dielectrochromatography on non-wetted thin layers
journal, August 2001

Dielectrophoretic Concentration and Separation of Live and Dead Bacteria in an Array of Insulators
journal, March 2004

Insulator-based dielectrophoresis for the selective concentration and separation of live bacteria in water
journal, June 2004

High-intensity, high-gradient electric separation and dielectric filtration of particulate and granular materials
journal, December 1982

Dielectrophoretic chromatography with cross-flow injection
conference, January 2002

Dielectrophoretic filter for separation and recovery of biological cells in water
journal, September 2003

Electrochromatography in Microchips: Reversed-Phase Separation of Peptides and Amino Acids Using Photopatterned Rigid Polymer Monoliths
journal, February 2002

Electroporation of Mammalian Cells in a Microfluidic Channel with Geometric Variation
journal, July 2006