Methods and compositions for targeting macromolecules into the nucleus

Chook, Yuh Min

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Title: Methods and compositions for targeting macromolecules into the nucleus

Abstract

The present invention includes compositions, methods and kits for directing an agent across the nuclear membrane of a cell. The present invention includes a Karyopherin beta2 translocation motif in a polypeptide having a slightly positively charged region or a slightly hydrophobic region and one or more R/K/H-X.sub.(2-5)-P-Y motifs. The polypeptide targets the agent into the cell nucleus.

Inventors:: Chook, Yuh Min

Issue Date:: Tue Jun 25 00:00:00 EDT 2013

Research Org.:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1086949

Patent Number(s):: 8470976

Application Number:: 11/697,656

Assignee:: Board of Regents, The University of Texas System (Austin, TX)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K38/00 - Medicinal preparations containing peptides

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/47 - from mammals
C07K2319/03 - containing a transmembrane segment
C07K2319/09 - containing a nuclear localisation signal

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N15/62 - DNA sequences coding for fusion proteins

Show less

DOE Contract Number:: W-31-109-ENG-38

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Chook, Yuh Min. Methods and compositions for targeting macromolecules into the nucleus.  United States: N. p., 2013. 
        Web.

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                    Chook, Yuh Min. Methods and compositions for targeting macromolecules into the nucleus.  United States.

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                    Chook, Yuh Min. Tue .  
        "Methods and compositions for targeting macromolecules into the nucleus".  United States.  https://www.osti.gov/servlets/purl/1086949.

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@article{osti_1086949,

  title        = {Methods and compositions for targeting macromolecules into the nucleus},

  author       = {Chook, Yuh Min},

  abstractNote = {The present invention includes compositions, methods and kits for directing an agent across the nuclear membrane of a cell. The present invention includes a Karyopherin beta2 translocation motif in a polypeptide having a slightly positively charged region or a slightly hydrophobic region and one or more R/K/H-X.sub.(2-5)-P-Y motifs. The polypeptide targets the agent into the cell nucleus.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jun 25 00:00:00 EDT 2013},

  month        = {Tue Jun 25 00:00:00 EDT 2013}

}

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Works referenced in this record:

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Loading and Unloading: Orchestrating Centrosome Duplication and Spindle Assembly by Ran/Crm1
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Rules for Nuclear Localization Sequence Recognition by Karyopherinβ2
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Similar Records

Title: Methods and compositions for targeting macromolecules into the nucleus

Abstract

Citation Formats

Identification of the Nucleocytoplasmic Shuttling Sequence of Heterogeneous Nuclear Ribonucleoprotein D-like Protein JKTBP and Its Interaction with mRNA journal, January 2002

Architecture of CRM1/Exportin1 Suggests How Cooperativity Is Achieved during Formation of a Nuclear Export Complex journal, December 2004

Structural basis for the assembly of a nuclear export complex journal, December 2004

Crm1 is a mitotic effector of Ran-GTP in somatic cells journal, May 2005

Uncoupling Kapβ2 Substrate Dissociation and Ran Binding journal, June 2002

Regulating Access to the Genome journal, February 2003

Conformational Variability of Nucleo-cytoplasmic Transport Factors journal, January 2004

Karyopherins and nuclear import journal, December 2001

Nucleo-Cytoplasmic Transport of Proteins as a Target for Therapeutic Drugs journal, May 2003

The Structure of Importin-ß Bound to SREBP-2: Nuclear Import of a Transcription Factor journal, November 2003

Karyopherins: from nuclear-transport mediators to nuclear-function regulators journal, October 2004

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox book, January 1994

Molecular Basis for the Recognition of a Nonclassical Nuclear Localization Signal by Importin β journal, December 2002

Swiss-Prot: Juggling between evolution and stability journal, January 2004

Likelihood-enhanced fast translation functions journal, March 2005

Protein sequence databases journal, February 2004

Nucleocytoplasmic transport enters the atomic age journal, June 2001

Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR journal, April 2004

Loading and Unloading: Orchestrating Centrosome Duplication and Spindle Assembly by Ran/Crm1 journal, August 2005

Two separate regions essential for nuclear import of the hnRNP D nucleocytoplasmic shuttling sequence: hnRNP D/AUF1 nucleo-cytoplasmic shuttling sequence journal, July 2005

Structural basis for nuclear import complex dissociation by RanGTP journal, May 2005

From The Cover: Transportin2 functions as importin and mediates nuclear import of HuR journal, February 2004

Rules for Nuclear Localization Sequence Recognition by Karyopherinβ2 journal, August 2006

Importin BetaConducting a Much Larger Cellular Symphony journal, November 2004

The Drosophila Heterogeneous Nuclear Ribonucleoprotein M Protein, HRP59, Regulates Alternative Splicing and Controls the Production of Its Own mRNA journal, December 2006

Protein Disorder Prediction journal, November 2003

Coot model-building tools for molecular graphics journal, November 2004

Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock journal, February 2005

The Structure of the Nuclear Export Receptor Cse1 in Its Cytosolic State Reveals a Closed Conformation Incompatible with Cargo Binding journal, April 2005

Two motifs essential for nuclear import of the hnRNP A1 nucleocytoplasmic shuttling sequence M9 core journal, January 2006

Additivity of mutational effects in proteins journal, September 1990

Nuclear import and activity of histone deacetylase in Xenopus oocytes is regulated by phosphorylation journal, April 2004

Identification of the Nucleocytoplasmic Shuttling Sequence of Heterogeneous Nuclear Ribonucleoprotein D-like Protein JKTBP and Its Interaction with mRNA
journal, January 2002

Architecture of CRM1/Exportin1 Suggests How Cooperativity Is Achieved during Formation of a Nuclear Export Complex
journal, December 2004

Structural basis for the assembly of a nuclear export complex
journal, December 2004

Crm1 is a mitotic effector of Ran-GTP in somatic cells
journal, May 2005

Uncoupling Kapβ2 Substrate Dissociation and Ran Binding
journal, June 2002

Regulating Access to the Genome
journal, February 2003

Conformational Variability of Nucleo-cytoplasmic Transport Factors
journal, January 2004

Karyopherins and nuclear import
journal, December 2001

Nucleo-Cytoplasmic Transport of Proteins as a Target for Therapeutic Drugs
journal, May 2003

The Structure of Importin-ß Bound to SREBP-2: Nuclear Import of a Transcription Factor
journal, November 2003

Karyopherins: from nuclear-transport mediators to nuclear-function regulators
journal, October 2004

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994

Molecular Basis for the Recognition of a Nonclassical Nuclear Localization Signal by Importin β
journal, December 2002

Swiss-Prot: Juggling between evolution and stability
journal, January 2004

Likelihood-enhanced fast translation functions
journal, March 2005

Protein sequence databases
journal, February 2004

Nucleocytoplasmic transport enters the atomic age
journal, June 2001

Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR
journal, April 2004

Loading and Unloading: Orchestrating Centrosome Duplication and Spindle Assembly by Ran/Crm1
journal, August 2005

Two separate regions essential for nuclear import of the hnRNP D nucleocytoplasmic shuttling sequence: hnRNP D/AUF1 nucleo-cytoplasmic shuttling sequence
journal, July 2005

Structural basis for nuclear import complex dissociation by RanGTP
journal, May 2005

From The Cover: Transportin2 functions as importin and mediates nuclear import of HuR
journal, February 2004

Rules for Nuclear Localization Sequence Recognition by Karyopherinβ2
journal, August 2006

Importin BetaConducting a Much Larger Cellular Symphony
journal, November 2004

The Drosophila Heterogeneous Nuclear Ribonucleoprotein M Protein, HRP59, Regulates Alternative Splicing and Controls the Production of Its Own mRNA
journal, December 2006

Protein Disorder Prediction
journal, November 2003

Coot model-building tools for molecular graphics
journal, November 2004

Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock
journal, February 2005

The Structure of the Nuclear Export Receptor Cse1 in Its Cytosolic State Reveals a Closed Conformation Incompatible with Cargo Binding
journal, April 2005

Two motifs essential for nuclear import of the hnRNP A1 nucleocytoplasmic shuttling sequence M9 core
journal, January 2006

Additivity of mutational effects in proteins
journal, September 1990

Nuclear import and activity of histone deacetylase in Xenopus oocytes is regulated by phosphorylation
journal, April 2004