Mosaic protein and nucleic acid vaccines against hepatitis C virus
Abstract
The invention relates to immunogenic compositions useful as HCV vaccines. Provided are HCV mosaic polypeptide and nucleic acid compositions which provide higher levels of T-cell epitope coverage while minimizing the occurrence of unnatural and rare epitopes compared to natural HCV polypeptides and consensus HCV sequences.
- Inventors:
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1084254
- Patent Number(s):
- 8460672
- Application Number:
- 12/893,731
- Assignee:
- Los Alamos National Security, LLC (Los Alamos, NM)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- AC52-06 NA 25396
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Yusim, Karina, Korber, Bette T. M., Kuiken, Carla L., and Fischer, William M. Mosaic protein and nucleic acid vaccines against hepatitis C virus. United States: N. p., 2013.
Web.
Yusim, Karina, Korber, Bette T. M., Kuiken, Carla L., & Fischer, William M. Mosaic protein and nucleic acid vaccines against hepatitis C virus. United States.
Yusim, Karina, Korber, Bette T. M., Kuiken, Carla L., and Fischer, William M. Tue .
"Mosaic protein and nucleic acid vaccines against hepatitis C virus". United States. https://www.osti.gov/servlets/purl/1084254.
@article{osti_1084254,
title = {Mosaic protein and nucleic acid vaccines against hepatitis C virus},
author = {Yusim, Karina and Korber, Bette T. M. and Kuiken, Carla L. and Fischer, William M.},
abstractNote = {The invention relates to immunogenic compositions useful as HCV vaccines. Provided are HCV mosaic polypeptide and nucleic acid compositions which provide higher levels of T-cell epitope coverage while minimizing the occurrence of unnatural and rare epitopes compared to natural HCV polypeptides and consensus HCV sequences.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 11 00:00:00 EDT 2013},
month = {Tue Jun 11 00:00:00 EDT 2013}
}
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