Peptide mediators of cholesterol efflux
Abstract
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1083792
- Patent Number(s):
- 8415293
- Application Number:
- 12/999,966
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Bielicki, John K., and Johansson, Jan. Peptide mediators of cholesterol efflux. United States: N. p., 2013.
Web.
Bielicki, John K., & Johansson, Jan. Peptide mediators of cholesterol efflux. United States.
Bielicki, John K., and Johansson, Jan. Tue .
"Peptide mediators of cholesterol efflux". United States. https://www.osti.gov/servlets/purl/1083792.
@article{osti_1083792,
title = {Peptide mediators of cholesterol efflux},
author = {Bielicki, John K. and Johansson, Jan},
abstractNote = {The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 09 00:00:00 EDT 2013},
month = {Tue Apr 09 00:00:00 EDT 2013}
}
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Works referenced in this record:
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journal, July 2003
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The C-Terminal Lipid-Binding Domain of Apolipoprotein E Is a Highly Efficient Mediator of ABCA1-Dependent Cholesterol Efflux that Promotes the Assembly of High-Density Lipoproteins
journal, March 2007
- Vedhachalam, Charulatha; Narayanaswami, Vasanthy; Neto, Nicole
- Biochemistry, Vol. 46, Issue 10, p. 2583-2593
The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum)
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