Means and methods for cytometric therapies
Abstract
A functionalized tip is incorporated into catheters for the cytometric delivery of cells into the brain and other body parts. For use in the brain, the tip forms part of a neurosurgical probe having a proximal end and a distal end. In addition to the functionalized tip, the probe has at least one cell slurry delivery lumen and a plurality of optical fibers configured along the probe, terminating in the tip to provide the photo-optical capability needed to monitor the viability and physiological behavior of the grafted cells as well as certain characteristics of the cellular environment. Details are also presented of the use of a neurocatheter having a cytometric tip of the type disclosed in the invention, as employed within the context of a feedback and control system for regulating the number of cells delivered to the brain of a patient.
- Inventors:
- Issue Date:
- Research Org.:
- ORO (Oak Ridge Office, Oak Ridge, TN (United States))
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1083012
- Patent Number(s):
- 8406837
- Application Number:
- 12/513,258
- Assignee:
- UT-Battelle, LLC (Oak Ridge, TN) ; University of Virginia Patent Foundation (Charlottesville, VA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
- DOE Contract Number:
- AC05-00OR22725
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Gillies, George T., Fillmore, Helen, Broaddus, William C., Evans, III, Boyd M., and Allison, Stephen W. Means and methods for cytometric therapies. United States: N. p., 2013.
Web.
Gillies, George T., Fillmore, Helen, Broaddus, William C., Evans, III, Boyd M., & Allison, Stephen W. Means and methods for cytometric therapies. United States.
Gillies, George T., Fillmore, Helen, Broaddus, William C., Evans, III, Boyd M., and Allison, Stephen W. Tue .
"Means and methods for cytometric therapies". United States. https://www.osti.gov/servlets/purl/1083012.
@article{osti_1083012,
title = {Means and methods for cytometric therapies},
author = {Gillies, George T. and Fillmore, Helen and Broaddus, William C. and Evans, III, Boyd M. and Allison, Stephen W.},
abstractNote = {A functionalized tip is incorporated into catheters for the cytometric delivery of cells into the brain and other body parts. For use in the brain, the tip forms part of a neurosurgical probe having a proximal end and a distal end. In addition to the functionalized tip, the probe has at least one cell slurry delivery lumen and a plurality of optical fibers configured along the probe, terminating in the tip to provide the photo-optical capability needed to monitor the viability and physiological behavior of the grafted cells as well as certain characteristics of the cellular environment. Details are also presented of the use of a neurocatheter having a cytometric tip of the type disclosed in the invention, as employed within the context of a feedback and control system for regulating the number of cells delivered to the brain of a patient.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 26 00:00:00 EDT 2013},
month = {Tue Mar 26 00:00:00 EDT 2013}
}
Works referenced in this record:
PET imaging of implanted human retinal pigment epithelial cells in the MPTP-induced primate model of Parkinson's disease
journal, October 2004
- Doudet, D.; Cornfeldt, M.; Honey, C.
- Experimental Neurology, Vol. 189, Issue 2