Compact conscious animal positron emission tomography scanner

Schyler, David J; O'Connor, Paul; Woody, Craig; Junnarkar, Sachin Shrirang; Radeka, Veljko; Vaska, Paul; Pratte, Jean-Francois; Volkow, Nora

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Title: Compact conscious animal positron emission tomography scanner

Abstract

A method of serially transferring annihilation information in a compact positron emission tomography (PET) scanner includes generating a time signal for an event, generating an address signal representing a detecting channel, generating a detector channel signal including the time and address signals, and generating a composite signal including the channel signal and similarly generated signals. The composite signal includes events from detectors in a block and is serially output. An apparatus that serially transfers annihilation information from a block includes time signal generators for detectors in a block and an address and channel signal generator. The PET scanner includes a ring tomograph that mounts onto a portion of an animal, which includes opposing block pairs. Each of the blocks in a block pair includes a scintillator layer, detection array, front-end array, and a serial encoder. The serial encoder includes time signal generators and an address signal and channel signal generator.

Inventors:

Schyler, David J ^[1]; O'Connor, Paul ^[1]; Woody, Craig ^[2]; Junnarkar, Sachin Shrirang ^[3]; Radeka, Veljko ^[1]; Vaska, Paul ^[3]; Pratte, Jean-Francois ^[4]; Volkow, Nora ^[5]

Bellport, NY
Setauket, NY
Sound Beach, NY
Stony Brook, NY
Chevy Chase, MD

Issue Date:: Tue Oct 24 00:00:00 EDT 2006

Research Org.:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1033756

Patent Number(s):: 7126126

Application Number:: 10/687,797

Assignee:: Brookhaven Science Associates, LLC (Upton, NY)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B6/037 - {Emission tomography
A61B6/4417 - {related to combined acquisition of different diagnostic modalities}
A61B6/508 - {for non-human patients}

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/481 - {MR combined with positron emission tomography [PET] or single photon emission computed tomography [SPECT]}

G - PHYSICS G01 - MEASURING G01T - MEASUREMENT OF NUCLEAR OR X-RADIATION
G01T1/2985 - {In depth localisation, e.g. using positron emitters

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DOE Contract Number:: AC02-98CH10886

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Citation Formats


                    Schyler, David J, O'Connor, Paul, Woody, Craig, Junnarkar, Sachin Shrirang, Radeka, Veljko, Vaska, Paul, Pratte, Jean-Francois, and Volkow, Nora. Compact conscious animal positron emission tomography scanner.  United States: N. p., 2006. 
        Web.

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                    Schyler, David J, O'Connor, Paul, Woody, Craig, Junnarkar, Sachin Shrirang, Radeka, Veljko, Vaska, Paul, Pratte, Jean-Francois, & Volkow, Nora. Compact conscious animal positron emission tomography scanner.  United States.

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                    Schyler, David J, O'Connor, Paul, Woody, Craig, Junnarkar, Sachin Shrirang, Radeka, Veljko, Vaska, Paul, Pratte, Jean-Francois, and Volkow, Nora. Tue .  
        "Compact conscious animal positron emission tomography scanner".  United States.  https://www.osti.gov/servlets/purl/1033756.

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@article{osti_1033756,

  title        = {Compact conscious animal positron emission tomography scanner},

  author       = {Schyler, David J and O'Connor, Paul and Woody, Craig and Junnarkar, Sachin Shrirang and Radeka, Veljko and Vaska, Paul and Pratte, Jean-Francois and Volkow, Nora},

  abstractNote = {A method of serially transferring annihilation information in a compact positron emission tomography (PET) scanner includes generating a time signal for an event, generating an address signal representing a detecting channel, generating a detector channel signal including the time and address signals, and generating a composite signal including the channel signal and similarly generated signals. The composite signal includes events from detectors in a block and is serially output. An apparatus that serially transfers annihilation information from a block includes time signal generators for detectors in a block and an address and channel signal generator. The PET scanner includes a ring tomograph that mounts onto a portion of an animal, which includes opposing block pairs. Each of the blocks in a block pair includes a scintillator layer, detection array, front-end array, and a serial encoder. The serial encoder includes time signal generators and an address signal and channel signal generator.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Oct 24 00:00:00 EDT 2006},

  month        = {Tue Oct 24 00:00:00 EDT 2006}

}

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System performance Simulations of the RatCAP awake rat brain scanner
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Shokouhi, S.; Vaska, P.; Schlyer, D. J.
IEEE Transactions on Nuclear Science, Vol. 52, Issue 5
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RatCAP: miniaturized head-mounted PET for conscious rodent brain imaging
journal, October 2004

Vaska, P.; Woody, C. L.; Schlyer, D. J.
IEEE Transactions on Nuclear Science, Vol. 51, Issue 5
https://doi.org/10.1109/TNS.2004.835740

Effects of intercrystal crosstalk on multielement LSO/APD PET detectors
journal, June 2003

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IEEE Transactions on Nuclear Science, Vol. 50, Issue 3
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journal, June 1997

Cherry, S. R.; Shao, Y.; Silverman, R. W.
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Similar Records

Title: Compact conscious animal positron emission tomography scanner

Abstract

Citation Formats

A CMOS fully compensated continuous reset system journal, January 2000

A 32-channel LSO matrix coupled to a monolithic 4×8 APD array for high resolution PET conference, January 2000

A Noninvasive LSO-APD Blood Radioactivity Monitor for PET Imaging Studies journal, October 2003

Spatial resolution of a noninvasive measurement of the arterial and venous input function using a wrist monitor conference, January 2004

Front-end electronics for the RatCAP mobile animal PET scanner conference, January 2003

Design of a fast-shaping amplifier for PET/CT APD detectors with depth-of-interaction journal, October 2002

Prospects for charge sensitive amplifiers in scaled CMOS journal, March 2002

Imaging the unanesthetized rat brain with PET: a feasibility study conference, January 2002

RatCAP: a small, head-mounted PET tomograph for imaging the brain of an awake RAT journal, July 2004

Front-end electronics for imaging detectors journal, September 2001

System performance Simulations of the RatCAP awake rat brain scanner journal, October 2005

RatCAP: miniaturized head-mounted PET for conscious rodent brain imaging journal, October 2004

Effects of intercrystal crosstalk on multielement LSO/APD PET detectors journal, June 2003

MicroPET: a high resolution PET scanner for imaging small animals journal, June 1997

A CMOS fully compensated continuous reset system
journal, January 2000

A 32-channel LSO matrix coupled to a monolithic 4×8 APD array for high resolution PET
conference, January 2000

A Noninvasive LSO-APD Blood Radioactivity Monitor for PET Imaging Studies
journal, October 2003

Spatial resolution of a noninvasive measurement of the arterial and venous input function using a wrist monitor
conference, January 2004

Front-end electronics for the RatCAP mobile animal PET scanner
conference, January 2003

Design of a fast-shaping amplifier for PET/CT APD detectors with depth-of-interaction
journal, October 2002

Prospects for charge sensitive amplifiers in scaled CMOS
journal, March 2002

Imaging the unanesthetized rat brain with PET: a feasibility study
conference, January 2002

RatCAP: a small, head-mounted PET tomograph for imaging the brain of an awake RAT
journal, July 2004

Front-end electronics for imaging detectors
journal, September 2001

System performance Simulations of the RatCAP awake rat brain scanner
journal, October 2005

RatCAP: miniaturized head-mounted PET for conscious rodent brain imaging
journal, October 2004

Effects of intercrystal crosstalk on multielement LSO/APD PET detectors
journal, June 2003

MicroPET: a high resolution PET scanner for imaging small animals
journal, June 1997