Hyperspectral microscope for in vivo imaging of microstructures and cells in tissues
Abstract
An optical hyperspectral/multimodal imaging method and apparatus is utilized to provide high signal sensitivity for implementation of various optical imaging approaches. Such a system utilizes long working distance microscope objectives so as to enable off-axis illumination of predetermined tissue thereby allowing for excitation at any optical wavelength, simplifies design, reduces required optical elements, significantly reduces spectral noise from the optical elements and allows for fast image acquisition enabling high quality imaging in-vivo. Such a technology provides a means of detecting disease at the single cell level such as cancer, precancer, ischemic, traumatic or other type of injury, infection, or other diseases or conditions causing alterations in cells and tissue micro structures.
- Inventors:
-
- Livermore, CA
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1018041
- Patent Number(s):
- 7945077
- Application Number:
- 11/292,406
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Demos, Stavros G. Hyperspectral microscope for in vivo imaging of microstructures and cells in tissues. United States: N. p., 2011.
Web.
Demos, Stavros G. Hyperspectral microscope for in vivo imaging of microstructures and cells in tissues. United States.
Demos, Stavros G. Tue .
"Hyperspectral microscope for in vivo imaging of microstructures and cells in tissues". United States. https://www.osti.gov/servlets/purl/1018041.
@article{osti_1018041,
title = {Hyperspectral microscope for in vivo imaging of microstructures and cells in tissues},
author = {Demos, Stavros G.},
abstractNote = {An optical hyperspectral/multimodal imaging method and apparatus is utilized to provide high signal sensitivity for implementation of various optical imaging approaches. Such a system utilizes long working distance microscope objectives so as to enable off-axis illumination of predetermined tissue thereby allowing for excitation at any optical wavelength, simplifies design, reduces required optical elements, significantly reduces spectral noise from the optical elements and allows for fast image acquisition enabling high quality imaging in-vivo. Such a technology provides a means of detecting disease at the single cell level such as cancer, precancer, ischemic, traumatic or other type of injury, infection, or other diseases or conditions causing alterations in cells and tissue micro structures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 17 00:00:00 EDT 2011},
month = {Tue May 17 00:00:00 EDT 2011}
}
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