Title: Selective high affinity polydentate ligands and methods of making such

Abstract

This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.

Inventors:

DeNardo, Sally ^[1]; DeNardo, Gerald ^[1]; Balhorn, Rodney ^[2]

---

+ Show Inventor Affiliations

1. El Macero, CA
2. Livermore, CA

Issue Date:

Tue Feb 16 00:00:00 EST 2010

Research Org.:

Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States); The Regents of California (Oakland, CA)

Sponsoring Org.:

USDOE

OSTI Identifier:

1014201

Patent Number(s):

7662785

Application Number:

US Patent Application 11/055,181

Assignee:

The Regents of California (Oakland, CA) ;Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

Show more

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P35/00 - Antineoplastic agents

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/574 - for cancer
G01N33/6803 - {General methods of protein analysis not limited to specific proteins or families of proteins}

Show less

DOE Contract Number:  

W-7405-ENG-48

Resource Type:

Patent

Country of Publication:

United States

Language:

English