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Title: The Scripps Research Institute (La Jolla, CA)

Abstract

The invention provides proteins attached to solid supports, and methods of preparing such solid support-bound proteins are provided. The proteins are attached to solid supports by means of an unnatural amino acid incorporated into the protein, which unnatural amino acid includes a reactive group that can react with a second reactive group that is attached to a solid support.

Inventors:
 [1];  [2]
  1. La Jolla, CA
  2. San Diego, CA
Issue Date:
Research Org.:
The Scripps Research Inst., La Jolla, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1014081
Patent Number(s):
7642085
Application Number:
US Patent Application 10/744,899
Assignee:
The Scripps Research Institute (La Jolla, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
DOE Contract Number:  
FG03-00ER45812
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Schultz, Peter G, and Wang, Lei. The Scripps Research Institute (La Jolla, CA). United States: N. p., 2010. Web.
Schultz, Peter G, & Wang, Lei. The Scripps Research Institute (La Jolla, CA). United States.
Schultz, Peter G, and Wang, Lei. Tue . "The Scripps Research Institute (La Jolla, CA)". United States. https://www.osti.gov/servlets/purl/1014081.
@article{osti_1014081,
title = {The Scripps Research Institute (La Jolla, CA)},
author = {Schultz, Peter G and Wang, Lei},
abstractNote = {The invention provides proteins attached to solid supports, and methods of preparing such solid support-bound proteins are provided. The proteins are attached to solid supports by means of an unnatural amino acid incorporated into the protein, which unnatural amino acid includes a reactive group that can react with a second reactive group that is attached to a solid support.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 05 00:00:00 EST 2010},
month = {Tue Jan 05 00:00:00 EST 2010}
}

Works referenced in this record:

Production and fluorescence-activated cell sorting of Escherichia coli expressing a functional antibody fragment on the external surface.
journal, November 1993


Progress toward the evolution of an organism with an expanded genetic code
journal, April 1999


Unprotected Peptides as Building Blocks for the Synthesis of Peptide Dendrimers with Oxime, Hydrazone, and Thiazolidine Linkages
journal, April 1995


Solid Phase Assembly of Defined Protein Conjugates
journal, September 2002


Biosensor chip mass spectrometry: A chip-based proteomics approach
journal, April 2000


Efficient introduction of aryl bromide functionality into proteins in vivo
journal, February 2000


Recent developments and applications of liquid-phase strategies in organic synthesis
journal, November 1999


Yeast forward and reverse 'n'-hybrid systems
journal, February 1999


Metallopeptide Design:  Tuning the Metal Cation Affinities with Unnatural Amino Acids and Peptide Secondary Structure
journal, January 1996


Site-Specific Protein Modification Using a Ketone Handle
journal, January 1996

  • Cornish, Virginia W.; Hahn, Klaus M.; Schultz, Peter G.
  • Journal of the American Chemical Society, Vol. 118, Issue 34, p. 8150-8151
  • https://doi.org/10.1021/ja961216x

A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
journal, February 2000


Addition of the keto functional group to the genetic code of Escherichia coli
journal, December 2002


A Novel Hydrazine Linker Resin and Its Application for the Solid-Phase Synthesis of α-Branched Primary Amines
journal, January 2001


A New Strategy for the Site-Specific Modification of Proteins in Vivo
journal, June 2003


Expanding the Genetic Code of Escherichia coli
journal, April 2001