Direct imaging of neural currents using ultra-low field magnetic resonance techniques
Abstract
Using resonant interactions to directly and tomographically image neural activity in the human brain using magnetic resonance imaging (MRI) techniques at ultra-low field (ULF), the present inventors have established an approach that is sensitive to magnetic field distributions local to the spin population in cortex at the Larmor frequency of the measurement field. Because the Larmor frequency can be readily manipulated (through varying B.sub.m), one can also envision using ULF-DNI to image the frequency distribution of the local fields in cortex. Such information, taken together with simultaneous acquisition of MEG and ULF-NMR signals, enables non-invasive exploration of the correlation between local fields induced by neural activity in cortex and more `distant` measures of brain activity such as MEG and EEG.
- Inventors:
-
- Los Alamos, NM
- (Los Alamos, NM)
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1013688
- Patent Number(s):
- 7573268
- Application Number:
- 11/678,023
- Assignee:
- Los Alamos National Security, LLC (Los Alamos, NM)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Volegov, Petr L, Matlashov, Andrei N, Mosher, John C, Espy, Michelle A, and Kraus, Jr., Robert H. Direct imaging of neural currents using ultra-low field magnetic resonance techniques. United States: N. p., 2009.
Web.
Volegov, Petr L, Matlashov, Andrei N, Mosher, John C, Espy, Michelle A, & Kraus, Jr., Robert H. Direct imaging of neural currents using ultra-low field magnetic resonance techniques. United States.
Volegov, Petr L, Matlashov, Andrei N, Mosher, John C, Espy, Michelle A, and Kraus, Jr., Robert H. Tue .
"Direct imaging of neural currents using ultra-low field magnetic resonance techniques". United States. https://www.osti.gov/servlets/purl/1013688.
@article{osti_1013688,
title = {Direct imaging of neural currents using ultra-low field magnetic resonance techniques},
author = {Volegov, Petr L and Matlashov, Andrei N and Mosher, John C and Espy, Michelle A and Kraus, Jr., Robert H.},
abstractNote = {Using resonant interactions to directly and tomographically image neural activity in the human brain using magnetic resonance imaging (MRI) techniques at ultra-low field (ULF), the present inventors have established an approach that is sensitive to magnetic field distributions local to the spin population in cortex at the Larmor frequency of the measurement field. Because the Larmor frequency can be readily manipulated (through varying B.sub.m), one can also envision using ULF-DNI to image the frequency distribution of the local fields in cortex. Such information, taken together with simultaneous acquisition of MEG and ULF-NMR signals, enables non-invasive exploration of the correlation between local fields induced by neural activity in cortex and more `distant` measures of brain activity such as MEG and EEG.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 11 00:00:00 EDT 2009},
month = {Tue Aug 11 00:00:00 EDT 2009}
}
Works referenced in this record:
Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging
journal, August 2003
- Xiong, Jinhu; Fox, Peter T.; Gao, Jia-Hong
- Human Brain Mapping, Vol. 20, Issue 1, p. 41-49
SQUID detected NMR in microtesla magnetic fields
journal, September 2004
- Matlachov, Andrei N.; Volegov, Petr L.; Espy, Michelle A.
- Journal of Magnetic Resonance, Vol. 170, Issue 1, p. 1-7
SQUID-Based Simultaneous Detection of NMR and Biomagnetic Signals at Ultra-Low Magnetic Fields
journal, June 2005
- Espy, M. A.; Matlachov, A. N.; Volegov, P. L.
- IEEE Transactions on Appiled Superconductivity, Vol. 15, Issue 2