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Title: Method of making gold thiolate and photochemically functionalized microcantilevers

Abstract

Highly sensitive sensor platforms for the detection of specific reagents, such as chromate, gasoline and biological species, using microcantilevers and other microelectromechanical systems (MEMS) whose surfaces have been modified with photochemically attached organic monolayers, such as self-assembled monolayers (SAM), or gold-thiol surface linkage are taught. The microcantilever sensors use photochemical hydrosilylation to modify silicon surfaces and gold-thiol chemistry to modify metallic surfaces thereby enabling individual microcantilevers in multicantilever array chips to be modified separately. Terminal vinyl substituted hydrocarbons with a variety of molecular recognition sites can be attached to the surface of silicon via the photochemical hydrosilylation process. By focusing the activating UV light sequentially on selected silicon or silicon nitride hydrogen terminated surfaces and soaking or spotting selected metallic surfaces with organic thiols, sulfides, or disulfides, the microcantilevers are functionalized. The device and photochemical method are intended to be integrated into systems for detecting specific agents including chromate groundwater contamination, gasoline, and biological species.

Inventors:
 [1];  [1];  [1];  [1];  [1];  [2]
  1. Knoxville, TN
  2. Nottingham, GB
Issue Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1013636
Patent Number(s):
7579052
Application Number:
11/859,047
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Boiadjiev, Vassil I, Brown, Gilbert M, Pinnaduwage, Lal A, Thundat, Thomas G, Bonnesen, Peter V, and Goretzki, Gudrun. Method of making gold thiolate and photochemically functionalized microcantilevers. United States: N. p., 2009. Web.
Boiadjiev, Vassil I, Brown, Gilbert M, Pinnaduwage, Lal A, Thundat, Thomas G, Bonnesen, Peter V, & Goretzki, Gudrun. Method of making gold thiolate and photochemically functionalized microcantilevers. United States.
Boiadjiev, Vassil I, Brown, Gilbert M, Pinnaduwage, Lal A, Thundat, Thomas G, Bonnesen, Peter V, and Goretzki, Gudrun. Tue . "Method of making gold thiolate and photochemically functionalized microcantilevers". United States. https://www.osti.gov/servlets/purl/1013636.
@article{osti_1013636,
title = {Method of making gold thiolate and photochemically functionalized microcantilevers},
author = {Boiadjiev, Vassil I and Brown, Gilbert M and Pinnaduwage, Lal A and Thundat, Thomas G and Bonnesen, Peter V and Goretzki, Gudrun},
abstractNote = {Highly sensitive sensor platforms for the detection of specific reagents, such as chromate, gasoline and biological species, using microcantilevers and other microelectromechanical systems (MEMS) whose surfaces have been modified with photochemically attached organic monolayers, such as self-assembled monolayers (SAM), or gold-thiol surface linkage are taught. The microcantilever sensors use photochemical hydrosilylation to modify silicon surfaces and gold-thiol chemistry to modify metallic surfaces thereby enabling individual microcantilevers in multicantilever array chips to be modified separately. Terminal vinyl substituted hydrocarbons with a variety of molecular recognition sites can be attached to the surface of silicon via the photochemical hydrosilylation process. By focusing the activating UV light sequentially on selected silicon or silicon nitride hydrogen terminated surfaces and soaking or spotting selected metallic surfaces with organic thiols, sulfides, or disulfides, the microcantilevers are functionalized. The device and photochemical method are intended to be integrated into systems for detecting specific agents including chromate groundwater contamination, gasoline, and biological species.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 25 00:00:00 EDT 2009},
month = {Tue Aug 25 00:00:00 EDT 2009}
}

Works referenced in this record:

Ultrasensitive Detection of CrO 4 2 - Using a Microcantilever Sensor
journal, April 2001


A 2-D Microcantilever Array for Multiplexed Biomolecular Analysis
journal, April 2004


Alkyl-terminated Si(111) surfaces: A high-resolution, core level photoelectron spectroscopy study
journal, January 1999


Selective Determination of Cr(VI) by a Self-Assembled Monolayer-Based Electrode
journal, March 1997


Selective detection of Cr(VI) using a microcantilever electrode coated with a self-assembled monolayer
journal, July 2005

  • Tian, F.; Boiadjiev, V. I.; Pinnaduwage, L. A.
  • Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films, Vol. 23, Issue 4
  • https://doi.org/10.1116/1.1943456

Organometallic Chemistry on Silicon and Germanium Surfaces
journal, May 2002


Nanomechanics for specific biological detection
conference, April 2003


Investigation of DNA Sensing Using Piezoresistive Microcantilever Probes
journal, August 2004


Formation, Characterization, and Chemistry of Undecanoic Acid-Terminated Silicon Surfaces:  Patterning and Immobilization of DNA
journal, December 2004


Detection of Hexavalent Chromium in Ground Water Using a Single Microcantilever Sensor
journal, March 2004


CMOS-based chemical microsensors
journal, December 2002


Roles of Charge Polarization and Steric Hindrance in Determining the Chemical Reactivity of Surface Si−H and Si−Si Bonds at H-Terminated Si(100) and -(111)
journal, January 2001


Sensitive detection of plastic explosives with self-assembled monolayer-coated microcantilevers
journal, August 2003


Photoreactivity of Unsaturated Compounds with Hydrogen-Terminated Silicon(111)
journal, June 2000


Tailor-Made Functionalization of Silicon Nitride Surfaces
journal, July 2004


Determination of the bonding of alkyl monolayers to the Si(111) surface using chemical-shift, scanned-energy photoelectron diffraction
journal, August 1997