Title: Synthetic heparin-binding factor analogs

Abstract

The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a linker, which may be a hydrophobic linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.

Inventors:

Pena, Louis A ^[1]; Zamora, Paul O ^[2]; Lin, Xinhua ^[3]; Glass, John D ^[4]

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+ Show Inventor Affiliations

1. Poquott, NY
2. Gaithersburg, MD
3. Plainview, NY
4. Shoreham, NY

Issue Date:

2010-04-20

Research Org.:

Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

989000

Patent Number(s):

7700563

Application Number:

7,700,563

Assignee:

BioSurface Engineering Technologies, Inc. (Rockville, MD); Brookhaven Science Associates (Upton, NY)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K38/00 - Medicinal preparations containing peptides
A61K38/1709 - {from mammals}
A61K38/1875 - {Bone morphogenic factor

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL

A61L27/34 - Macromolecular materials

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P19/08 - for bone diseases, e.g. rachitism, Paget's disease

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS

C07H21/04 - with deoxyribosyl as saccharide radical

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K14/4705 - {stimulating, promoting or activating activity}
C07K14/503 - {basic FGF [bFGF]}
C07K2319/00 - Fusion polypeptide

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS

C08L89/00 - Compositions of proteins

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DOE Contract Number:  

AC02-98CH10886

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY