Methods and compositions for diagnosing and preventing a group B streptococcal infection
Abstract
The present invention provides a group B streptococcal (GBS) surface antigen, designated epsilon antigen, that is co-expressed with the delta antigen on a subset of serotype III GBS. Epsilon is expressed on more pathogenic Restriction Digest Pattern (RDP) III-3 GBS, but not on RDP types 1, 2, or 4. Accordingly, the present invention provides compositions and methods for detecting a group B streptococcus serotype III, RDP III-3 strain. Vaccines and methods of identifying agents which inhibit adhesion of a group B streptococcal cell to a host cell are also provided.
- Inventors:
-
- Gainesville, FL
- Harrisonburg, VA
- Memphis, TN
- Salt Lake City, UT
- Issue Date:
- Research Org.:
- St. Jude Children's Research Hospital (Memphis, TN); Univ. of Florida, Gainesville, FL (United States); University of Utah Research Foundation (Salt Lake City, UT)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 988819
- Patent Number(s):
- 7588773
- Application Number:
- 11/574,067
- Assignee:
- St. Jude Children's Research Hospital (Memphis, TN); University of Florida (Gainesville, FL); University of Utah Research Foundation (Salt Lake City, UT)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- FG05-93ER20097
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Brady, Linda Jeannine, Seifert, Kyle N, Adderson, Elisabeth E, and Bohnsack, John F. Methods and compositions for diagnosing and preventing a group B streptococcal infection. United States: N. p., 2009.
Web.
Brady, Linda Jeannine, Seifert, Kyle N, Adderson, Elisabeth E, & Bohnsack, John F. Methods and compositions for diagnosing and preventing a group B streptococcal infection. United States.
Brady, Linda Jeannine, Seifert, Kyle N, Adderson, Elisabeth E, and Bohnsack, John F. Tue .
"Methods and compositions for diagnosing and preventing a group B streptococcal infection". United States. https://www.osti.gov/servlets/purl/988819.
@article{osti_988819,
title = {Methods and compositions for diagnosing and preventing a group B streptococcal infection},
author = {Brady, Linda Jeannine and Seifert, Kyle N and Adderson, Elisabeth E and Bohnsack, John F},
abstractNote = {The present invention provides a group B streptococcal (GBS) surface antigen, designated epsilon antigen, that is co-expressed with the delta antigen on a subset of serotype III GBS. Epsilon is expressed on more pathogenic Restriction Digest Pattern (RDP) III-3 GBS, but not on RDP types 1, 2, or 4. Accordingly, the present invention provides compositions and methods for detecting a group B streptococcus serotype III, RDP III-3 strain. Vaccines and methods of identifying agents which inhibit adhesion of a group B streptococcal cell to a host cell are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 15 00:00:00 EDT 2009},
month = {Tue Sep 15 00:00:00 EDT 2009}
}
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Works referenced in this record:
beta-Endorphin omission analogs: dissociation of immunoreactivity from other biological activities.
journal, June 1980
- Li, C. H.; Yamashiro, D.; Tseng, L. F.
- Proceedings of the National Academy of Sciences, Vol. 77, Issue 6
A single amino acid substitution in a common african allele of the CD4 molecule ablates binding of the monoclonal antibody, OKT4
journal, November 1991
- Lederman, Seth; DeMartino, Julie A.; Daugherty, Bruce L.
- Molecular Immunology, Vol. 28, Issue 11
Long-Range Mapping of the Streptococcus agalactiae Phylogenetic Lineage Restriction Digest Pattern Type III-3 Reveals Clustering of Virulence Genes
journal, January 2002
- Bohnsack, John F.; Whiting, April A.; Bradford, Russell D.
- Infection and Immunity, Vol. 70, Issue 1
Antibodies Reactive with the N-Terminal Domain ofPlasmodium falciparum Serine Repeat Antigen Inhibit Cell Proliferation by Agglutinating Merozoites and Schizonts
journal, January 1999
- Pang, Xin-Li; Mitamura, Toshihide; Horii, Toshihiro
- Infection and Immunity, Vol. 67, Issue 4
Identification of a Highly Encapsulated, Genetically Related Group of Invasive Type III Group B Streptococci
journal, April 1998
- Takahashi, Shinji; Adderson, Elisabeth E.; Nagano, Yukiko
- The Journal of Infectious Diseases, Vol. 177, Issue 4