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Title: Methods and compositions for diagnosing and preventing a group B streptococcal infection

Abstract

The present invention provides a group B streptococcal (GBS) surface antigen, designated epsilon antigen, that is co-expressed with the delta antigen on a subset of serotype III GBS. Epsilon is expressed on more pathogenic Restriction Digest Pattern (RDP) III-3 GBS, but not on RDP types 1, 2, or 4. Accordingly, the present invention provides compositions and methods for detecting a group B streptococcus serotype III, RDP III-3 strain. Vaccines and methods of identifying agents which inhibit adhesion of a group B streptococcal cell to a host cell are also provided.

Inventors:
 [1];  [2];  [3];  [4]
  1. Gainesville, FL
  2. Harrisonburg, VA
  3. Memphis, TN
  4. Salt Lake City, UT
Issue Date:
Research Org.:
St. Jude Children's Research Hospital (Memphis, TN); Univ. of Florida, Gainesville, FL (United States); University of Utah Research Foundation (Salt Lake City, UT)
Sponsoring Org.:
USDOE
OSTI Identifier:
988819
Patent Number(s):
7588773
Application Number:
11/574,067
Assignee:
St. Jude Children's Research Hospital (Memphis, TN); University of Florida (Gainesville, FL); University of Utah Research Foundation (Salt Lake City, UT)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
FG05-93ER20097
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Brady, Linda Jeannine, Seifert, Kyle N, Adderson, Elisabeth E, and Bohnsack, John F. Methods and compositions for diagnosing and preventing a group B streptococcal infection. United States: N. p., 2009. Web.
Brady, Linda Jeannine, Seifert, Kyle N, Adderson, Elisabeth E, & Bohnsack, John F. Methods and compositions for diagnosing and preventing a group B streptococcal infection. United States.
Brady, Linda Jeannine, Seifert, Kyle N, Adderson, Elisabeth E, and Bohnsack, John F. Tue . "Methods and compositions for diagnosing and preventing a group B streptococcal infection". United States. https://www.osti.gov/servlets/purl/988819.
@article{osti_988819,
title = {Methods and compositions for diagnosing and preventing a group B streptococcal infection},
author = {Brady, Linda Jeannine and Seifert, Kyle N and Adderson, Elisabeth E and Bohnsack, John F},
abstractNote = {The present invention provides a group B streptococcal (GBS) surface antigen, designated epsilon antigen, that is co-expressed with the delta antigen on a subset of serotype III GBS. Epsilon is expressed on more pathogenic Restriction Digest Pattern (RDP) III-3 GBS, but not on RDP types 1, 2, or 4. Accordingly, the present invention provides compositions and methods for detecting a group B streptococcus serotype III, RDP III-3 strain. Vaccines and methods of identifying agents which inhibit adhesion of a group B streptococcal cell to a host cell are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {9}
}

Works referenced in this record:

beta-Endorphin omission analogs: dissociation of immunoreactivity from other biological activities.
journal, June 1980


A single amino acid substitution in a common african allele of the CD4 molecule ablates binding of the monoclonal antibody, OKT4
journal, November 1991


Identification of a Highly Encapsulated, Genetically Related Group of Invasive Type III Group B Streptococci
journal, April 1998