Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications
Abstract
The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined array. The hybrid magnetic structure provides means for separation and other biotechnology applications involving holding, manipulation, or separation of magnetizable molecular structures and targets. Also disclosed are hybrid magnetic tweezers able to exert approximately 1 nN of force to 4.5 .mu.m magnetic bead. The maximum force was experimentally measured to be .about.900 pN which is in good agreement with theoretical estimations and other measurements. In addition, a new analysis scheme that permits fast real-time position measurement in typical geometry of magnetic tweezers has been developed and described in detail.
- Inventors:
-
- El Cerrito, CA
- Seoul, KR
- (Berkeley, CA)
- Berkeley, CA
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 985856
- Patent Number(s):
- 7474184
- Application Number:
- 11/355,462
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B03 - SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS B03C - MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01F - MAGNETS
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Humphries, David E, Hong, Seok-Cheol, Cozzarelli, legal representative, Linda A., Pollard, Martin J, and Cozzarelli, Nicholas R. Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications. United States: N. p., 2009.
Web.
Humphries, David E, Hong, Seok-Cheol, Cozzarelli, legal representative, Linda A., Pollard, Martin J, & Cozzarelli, Nicholas R. Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications. United States.
Humphries, David E, Hong, Seok-Cheol, Cozzarelli, legal representative, Linda A., Pollard, Martin J, and Cozzarelli, Nicholas R. Tue .
"Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications". United States. https://www.osti.gov/servlets/purl/985856.
@article{osti_985856,
title = {Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications},
author = {Humphries, David E and Hong, Seok-Cheol and Cozzarelli, legal representative, Linda A. and Pollard, Martin J and Cozzarelli, Nicholas R},
abstractNote = {The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined array. The hybrid magnetic structure provides means for separation and other biotechnology applications involving holding, manipulation, or separation of magnetizable molecular structures and targets. Also disclosed are hybrid magnetic tweezers able to exert approximately 1 nN of force to 4.5 .mu.m magnetic bead. The maximum force was experimentally measured to be .about.900 pN which is in good agreement with theoretical estimations and other measurements. In addition, a new analysis scheme that permits fast real-time position measurement in typical geometry of magnetic tweezers has been developed and described in detail.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 06 00:00:00 EST 2009},
month = {Tue Jan 06 00:00:00 EST 2009}
}
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