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Title: Positive modulator of bone morphogenic protein-2

Abstract

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

Inventors:
 [1];  [2];  [3];  [4]
  1. Gaithersburg, MD
  2. Poquott, NY
  3. Plainview, NY
  4. Germantown, MD
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
985852
Patent Number(s):
7482427
Application Number:
11/064,039
Assignee:
BioSurface Engineering Technologies, Inc. (College Park, MD) Brookhaven Science Associates (Upton, NY)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Zamora, Paul O, Pena, Louis A, Lin, Xinhua, and Takahashi, Kazuyuki. Positive modulator of bone morphogenic protein-2. United States: N. p., 2009. Web.
Zamora, Paul O, Pena, Louis A, Lin, Xinhua, & Takahashi, Kazuyuki. Positive modulator of bone morphogenic protein-2. United States.
Zamora, Paul O, Pena, Louis A, Lin, Xinhua, and Takahashi, Kazuyuki. Tue . "Positive modulator of bone morphogenic protein-2". United States. https://www.osti.gov/servlets/purl/985852.
@article{osti_985852,
title = {Positive modulator of bone morphogenic protein-2},
author = {Zamora, Paul O and Pena, Louis A and Lin, Xinhua and Takahashi, Kazuyuki},
abstractNote = {Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {1}
}

Works referenced in this record:

Engineering of an FGF–proteoglycan fusion protein with heparin-independent, mitogenic activity
journal, June 2000


Influence of BMPs on the Formation of Osteoblastic Lesions in Metastatic Prostate Cancer
journal, August 2005


A Functional Fibroblast Growth Factor-1 Immunoglobulin Fusion Protein
journal, June 1998


A heparin binding synthetic peptide from human HIP / RPL29 fails to specifically differentiate between anticoagulantly active and inactive species of heparin
journal, February 2003


BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II
journal, July 2000


Synthesis of Native Proteins by Chemical Ligation
journal, June 2000


Interleukin 1 regulates heparin-binding growth factor 2 gene expression in vascular smooth muscle cells.
journal, January 1991


Poly(L-lysine) has different membrane transport and drug-carrier properties when complexed with heparin.
journal, December 1981


Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis
journal, April 2000