Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same
Abstract
A compound containing at least two aromatic rings covalently bonded together, with each aromatic ring containing at least one oxyacetamide-based side chain, the compound being capable of forming a chloride ion channel across a lipid bilayer, and transporting chloride ion across the lipid bilayer.
- Inventors:
-
- College Park, MD
- Richmond, VA
- New Phila., PA
- Issue Date:
- Research Org.:
- The University of Maryland (College Park, MD)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 985688
- Patent Number(s):
- 7355074
- Application Number:
- 10/771,414
- Assignee:
- The University of Maryland (College Park, MD)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
- DOE Contract Number:
- US patent application 10/771,414
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Davis, Jeffery T, Sidorov, Vladimir, and Kotch, Frank W. Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same. United States: N. p., 2008.
Web.
Davis, Jeffery T, Sidorov, Vladimir, & Kotch, Frank W. Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same. United States.
Davis, Jeffery T, Sidorov, Vladimir, and Kotch, Frank W. Tue .
"Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same". United States. https://www.osti.gov/servlets/purl/985688.
@article{osti_985688,
title = {Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same},
author = {Davis, Jeffery T and Sidorov, Vladimir and Kotch, Frank W},
abstractNote = {A compound containing at least two aromatic rings covalently bonded together, with each aromatic ring containing at least one oxyacetamide-based side chain, the compound being capable of forming a chloride ion channel across a lipid bilayer, and transporting chloride ion across the lipid bilayer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {4}
}
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Works referenced in this record:
Ion Channel Formation from a Calix[4]arene Amide That Binds HCl
journal, March 2002
- Sidorov, Vladimir; Kotch, Frank W.; Abdrakhmanova, Galya
- Journal of the American Chemical Society, Vol. 124, Issue 10
Interchain hydrogen-bonding interactions may facilitate translocation of K+ ions across the potassium channel selectivity filter, as suggested by synthetic modeling chemistry
journal, August 2001
- Mareque Rivas, J. C.; Schwalbe, H.; Lippard, S. J.
- Proceedings of the National Academy of Sciences, Vol. 98, Issue 17
Toward artificial ion channels: self-assembled nanotubes from calix[4]arene–guanosine conjugates
journal, January 2000
- Sidorov, Vladimir; Kotch, Frank W.; Davis, Jeffery T.
- Chemical Communications, Issue 23
SCMTR: A Chloride-Selective, Membrane-Anchored Peptide Channel that Exhibits Voltage Gating
journal, March 2002
- Schlesinger, Paul H.; Ferdani, Riccardo; Liu, Jun
- Journal of the American Chemical Society, Vol. 124, Issue 9
Chloride Transport Across Lipid Bilayers and Transmembrane Potential Induction by an Oligophenoxyacetamide
journal, March 2003
- Sidorov, Vladimir; Kotch, Frank W.; Kuebler, Jennifer L.
- Journal of the American Chemical Society, Vol. 125, Issue 10