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Title: Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same

Abstract

A compound containing at least two aromatic rings covalently bonded together, with each aromatic ring containing at least one oxyacetamide-based side chain, the compound being capable of forming a chloride ion channel across a lipid bilayer, and transporting chloride ion across the lipid bilayer.

Inventors:
 [1];  [2];  [3]
  1. College Park, MD
  2. Richmond, VA
  3. New Phila., PA
Issue Date:
Research Org.:
The University of Maryland (College Park, MD)
Sponsoring Org.:
USDOE
OSTI Identifier:
985688
Patent Number(s):
7355074
Application Number:
10/771,414
Assignee:
The University of Maryland (College Park, MD)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
DOE Contract Number:  
US patent application 10/771,414
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Davis, Jeffery T, Sidorov, Vladimir, and Kotch, Frank W. Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same. United States: N. p., 2008. Web.
Davis, Jeffery T, Sidorov, Vladimir, & Kotch, Frank W. Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same. United States.
Davis, Jeffery T, Sidorov, Vladimir, and Kotch, Frank W. Tue . "Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same". United States. https://www.osti.gov/servlets/purl/985688.
@article{osti_985688,
title = {Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same},
author = {Davis, Jeffery T and Sidorov, Vladimir and Kotch, Frank W},
abstractNote = {A compound containing at least two aromatic rings covalently bonded together, with each aromatic ring containing at least one oxyacetamide-based side chain, the compound being capable of forming a chloride ion channel across a lipid bilayer, and transporting chloride ion across the lipid bilayer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {4}
}

Patent:

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Works referenced in this record:

Ion Channel Formation from a Calix[4]arene Amide That Binds HCl
journal, March 2002


Interchain hydrogen-bonding interactions may facilitate translocation of K+ ions across the potassium channel selectivity filter, as suggested by synthetic modeling chemistry
journal, August 2001


Toward artificial ion channels: self-assembled nanotubes from calix[4]arene–guanosine conjugates
journal, January 2000


SCMTR:  A Chloride-Selective, Membrane-Anchored Peptide Channel that Exhibits Voltage Gating
journal, March 2002


Chloride Transport Across Lipid Bilayers and Transmembrane Potential Induction by an Oligophenoxyacetamide
journal, March 2003