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Title: Photoinitiated grafting of porous polymer monoliths and thermoplastic polymers for microfluidic devices

Abstract

A microfluidic device preferably made of a thermoplastic polymer that includes a channel or a multiplicity of channels whose surfaces are modified by photografting. The device further includes a porous polymer monolith prepared via UV initiated polymerization within the channel, and functionalization of the pore surface of the monolith using photografting. Processes for making such surface modifications of thermoplastic polymers and porous polymer monoliths are set forth.

Inventors:
 [1];  [2];  [3]
  1. Oakland, CA
  2. Alameda, CA
  3. Leiden, NL
Issue Date:
Research Org.:
Univ. of California (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
985414
Patent Number(s):
7431888
Application Number:
10/665,900
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Frechet, Jean M. J., Svec, Frantisek, and Rohr, Thomas. Photoinitiated grafting of porous polymer monoliths and thermoplastic polymers for microfluidic devices. United States: N. p., 2008. Web.
Frechet, Jean M. J., Svec, Frantisek, & Rohr, Thomas. Photoinitiated grafting of porous polymer monoliths and thermoplastic polymers for microfluidic devices. United States.
Frechet, Jean M. J., Svec, Frantisek, and Rohr, Thomas. Tue . "Photoinitiated grafting of porous polymer monoliths and thermoplastic polymers for microfluidic devices". United States. https://www.osti.gov/servlets/purl/985414.
@article{osti_985414,
title = {Photoinitiated grafting of porous polymer monoliths and thermoplastic polymers for microfluidic devices},
author = {Frechet, Jean M. J. and Svec, Frantisek and Rohr, Thomas},
abstractNote = {A microfluidic device preferably made of a thermoplastic polymer that includes a channel or a multiplicity of channels whose surfaces are modified by photografting. The device further includes a porous polymer monolith prepared via UV initiated polymerization within the channel, and functionalization of the pore surface of the monolith using photografting. Processes for making such surface modifications of thermoplastic polymers and porous polymer monoliths are set forth.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {10}
}

Works referenced in this record:

Fabrication of porous polymer monoliths covalently attached to the walls of channels in plastic microdevices
journal, November 2003


Rapid electrochromatographic enantiomer separations on short molecularly imprinted polymer monoliths
journal, May 2001


Preparation of monolithic polymers with controlled porous properties for microfluidic chip applications using photoinitiated free-radical polymerization: Monolithic Polymers
journal, January 2002


Use of Stable Free Radicals for the Sequential Preparation and Surface Grafting of Functionalized Macroporous Monoliths
journal, October 2000


Polymer surface with graft chains
journal, February 2003


Surface photografting of polymer fibers, films and sheets
journal, May 1999

  • Rånby, B.; Yang, W. T.; Tretinnikov, O.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 151, Issue 1-4, p. 301-305
  • https://doi.org/10.1016/S0168-583X(99)00158-5

Plasma surface modification of polymers for improved adhesion: a critical review
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Surface modification of polymeric biomaterials by albumin grafting using γ-irradiation
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A Novel Surface Photo-Graft Polymerization Method for Fabricated Devices
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Micro Total Analysis Systems. 1. Introduction, Theory, and Technology
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Surface modification of poly-L-lactic acid (PLLA) membrane by grafting acrylamide: an effective way to improve cytocompatibility for chondrocytes
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Graft copolymer of polyacrylamide and natural rubber produced by means of ultraviolet light
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Continuous rods of macroporous polymer as high-performance liquid chromatography separation media
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Surface Modification of Poly(dimethylsiloxane) Microfluidic Devices by Ultraviolet Polymer Grafting
journal, August 2002


Electrochromatography in Microchips:  Reversed-Phase Separation of Peptides and Amino Acids Using Photopatterned Rigid Polymer Monoliths
journal, February 2002


Protein patterning by maskless photolithography on hydrophilic polymer-grafted surface
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Surface modification of polymers by photoinitiated graft polymerization
journal, October 1992