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Title: Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams

Abstract

A method of assisting recovery of an injury site of the central nervous system (CNS) or treating a disease includes providing a therapeutic dose of X-ray radiation to a target volume through an array of parallel microplanar beams. The dose to treat CNS injury temporarily removes regeneration inhibitors from the irradiated site. Substantially unirradiated cells surviving between beams migrate to the in-beam portion and assist recovery. The dose may be staggered in fractions over sessions using angle-variable intersecting microbeam arrays (AVIMA). Additional doses are administered by varying the orientation of the beams. The method is enhanced by injecting stem cells into the injury site. One array or the AVIMA method is applied to ablate selected cells in a target volume associated with disease for palliative or curative effect. Atrial fibrillation is treated by irradiating the atrial wall to destroy myocardial cells while continuously rotating the subject.

Inventors:
 [1];  [2];  [3];  [4];  [5]
  1. Yaphank, NY
  2. Rocky Point, NY
  3. Holden, MA
  4. Monteroduni, IT
  5. Shoreham, NY
Issue Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
985214
Patent Number(s):
7746979
Application Number:
11/884,158
Assignee:
The United States of America as represented by the United States Department of Energy (Washington, DC)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

Dilmanian, F Avraham, Anchel, David J, Gaudette, Glenn, Romanelli, Pantaleo, and Hainfeld, James. Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams. United States: N. p., 2010. Web.
Dilmanian, F Avraham, Anchel, David J, Gaudette, Glenn, Romanelli, Pantaleo, & Hainfeld, James. Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams. United States.
Dilmanian, F Avraham, Anchel, David J, Gaudette, Glenn, Romanelli, Pantaleo, and Hainfeld, James. Tue . "Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams". United States. https://www.osti.gov/servlets/purl/985214.
@article{osti_985214,
title = {Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams},
author = {Dilmanian, F Avraham and Anchel, David J and Gaudette, Glenn and Romanelli, Pantaleo and Hainfeld, James},
abstractNote = {A method of assisting recovery of an injury site of the central nervous system (CNS) or treating a disease includes providing a therapeutic dose of X-ray radiation to a target volume through an array of parallel microplanar beams. The dose to treat CNS injury temporarily removes regeneration inhibitors from the irradiated site. Substantially unirradiated cells surviving between beams migrate to the in-beam portion and assist recovery. The dose may be staggered in fractions over sessions using angle-variable intersecting microbeam arrays (AVIMA). Additional doses are administered by varying the orientation of the beams. The method is enhanced by injecting stem cells into the injury site. One array or the AVIMA method is applied to ablate selected cells in a target volume associated with disease for palliative or curative effect. Atrial fibrillation is treated by irradiating the atrial wall to destroy myocardial cells while continuously rotating the subject.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {6}
}

Works referenced in this record:

Microbeam radiation therapy: Microbeam radiation therapy
journal, November 1992


A white-beam fast-shutter for microbeam radiation therapy at the ESRF
journal, March 2002

  • Renier, M.; Brochard, T.; Nemoz, C.
  • Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 479, Issue 2-3
  • https://doi.org/10.1016/S0168-9002(01)00905-6

Design of a multislit, variable width collimator for microplanar beam radiotherapy
journal, February 1995


Uniaxial and biaxial irradiation protocols for microbeam radiation therapy
journal, June 2004


Cure of Fisher Rats Bearing Radioresistant F98 Glioma Treated with cis -Platinum and Irradiated with Monochromatic Synchrotron X-Rays
journal, April 2004


The use of gold nanoparticles to enhance radiotherapy in mice
journal, September 2004


Murine EMT-6 Carcinoma: High Therapeutic Efficacy of Microbeam Radiation Therapy
journal, May 2003


Weanling piglet cerebellum: a surrogate for tolerance to MRT (microbeam radiation therapy) in pediatric neuro-oncology
conference, December 2001


Tumour dose enhancement using modified megavoltage photon beams and contrast media
journal, July 2002


Beneficial effects of x-irradiation on recovery of lesioned mammalian central nervous tissue.
journal, December 1990


Boron neutron capture therapy: principles and prospects
journal, August 1998


Use of Magnetic Resonance Imaging to Assess Blood-Brain/Blood-Glioma Barrier Opening During Conformal Radiotherapy
journal, June 2005


Subacute neuropathological effects of microplanar beams of x-rays from a synchrotron wiggler.
journal, September 1995


Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated X rays
journal, November 1998


Tissue lesions caused by microplanar beams of synchrotron-generated X-rays in Drosophila melanogaster
journal, January 2000


Exploiting geometrical irradiation possibilities in MRT application
journal, August 2005

  • Bräuer-Krisch, E.; Requardt, H.; Régnard, P.
  • Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 548, Issue 1-2
  • https://doi.org/10.1016/j.nima.2005.03.068

New irradiation geometry for microbeam radiation therapy
journal, June 2005


Structural recovery in lesioned adult mammalian spinal cord by x-irradiation of the lesion site.
journal, October 1996