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Title: Microfluidic systems and methods for transport and lysis of cells and analysis of cell lysate

Abstract

Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rapid lysis, thereby minimizing continued cellular activity and resulting in greater accuracy of analysis of cell processes.

Inventors:
 [1];  [2];  [2];  [2]
  1. Oak Ridge, TN
  2. Knoxville, TN
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
985165
Patent Number(s):
7,419,575
Application Number:
10/858,096
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Culbertson, Christopher T, Jacobson, Stephen C, McClain, Maxine A, and Ramsey, J Michael. Microfluidic systems and methods for transport and lysis of cells and analysis of cell lysate. United States: N. p., 2008. Web.
Culbertson, Christopher T, Jacobson, Stephen C, McClain, Maxine A, & Ramsey, J Michael. Microfluidic systems and methods for transport and lysis of cells and analysis of cell lysate. United States.
Culbertson, Christopher T, Jacobson, Stephen C, McClain, Maxine A, and Ramsey, J Michael. Tue . "Microfluidic systems and methods for transport and lysis of cells and analysis of cell lysate". United States. https://www.osti.gov/servlets/purl/985165.
@article{osti_985165,
title = {Microfluidic systems and methods for transport and lysis of cells and analysis of cell lysate},
author = {Culbertson, Christopher T and Jacobson, Stephen C and McClain, Maxine A and Ramsey, J Michael},
abstractNote = {Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rapid lysis, thereby minimizing continued cellular activity and resulting in greater accuracy of analysis of cell processes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {9}
}

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