Method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation in conjunction with mass spectrometric analysis
Abstract
The invention relates to a method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation (SID) in conjunction with mass spectrometric analysis. Results demonstrate formation of a wide distribution of structure-specific fragments having wide sequence coverage useful for sequencing and identifying the complex molecules.
- Inventors:
-
- Richland, WA
- Issue Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 985154
- Patent Number(s):
- 7365312
- Application Number:
- 11/605,881
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Classifications (CPCs):
-
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- DOE Contract Number:
- AC06-76RL01830
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Laskin, Julia, and Futrell, Jean H. Method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation in conjunction with mass spectrometric analysis. United States: N. p., 2008.
Web.
Laskin, Julia, & Futrell, Jean H. Method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation in conjunction with mass spectrometric analysis. United States.
Laskin, Julia, and Futrell, Jean H. Tue .
"Method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation in conjunction with mass spectrometric analysis". United States. https://www.osti.gov/servlets/purl/985154.
@article{osti_985154,
title = {Method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation in conjunction with mass spectrometric analysis},
author = {Laskin, Julia and Futrell, Jean H},
abstractNote = {The invention relates to a method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation (SID) in conjunction with mass spectrometric analysis. Results demonstrate formation of a wide distribution of structure-specific fragments having wide sequence coverage useful for sequencing and identifying the complex molecules.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 29 00:00:00 EDT 2008},
month = {Tue Apr 29 00:00:00 EDT 2008}
}
Works referenced in this record:
Proposal for an analytical form of the collisional energy deposition probability
journal, February 1987
- Lee, S. H.; Kim, M. S.; Beynon, J. H.
- International Journal of Mass Spectrometry and Ion Processes, Vol. 75, Issue 1
Intra-ionic interactions in electrosprayed peptide ions
journal, March 1997
- Summerfield, Scott G.; Whiting, Andrew; Gaskell, Simon J.
- International Journal of Mass Spectrometry and Ion Processes, Vol. 162, Issue 1-3
Dissociative and Reactive Hyperthermal Ion−Surface Collisions with Langmuir−Blodgett Films Terminated by CF 3 (CH 2 ) n −, n -Perfluoroalkyl, or n -Alkyl Groups
journal, November 1999
- Gu, Chungang; Wysocki, Vicki H.; Harada, Atsuhiro
- Journal of the American Chemical Society, Vol. 121, Issue 45
Matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry with pulsed in-source collision gas and in-source ion accumulation
journal, January 2000
- Baykut, G.; Jertz, Roland; Witt, Matthias
- Rapid Communications in Mass Spectrometry, Vol. 14, Issue 14, p. 1238-1247
A High-performance Modular Data System for Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
journal, November 1996
- Senko, Michael W.; Canterbury, Jesse D.; Guan, Shenheng
- Rapid Communications in Mass Spectrometry, Vol. 10, Issue 14, p. 1839-1844
Shattering of Peptide Ions on Self-Assembled Monolayer Surfaces
journal, February 2003
- Laskin, Julia; Bailey, Thomas H.; Futrell, Jean H.
- Journal of the American Chemical Society, Vol. 125, Issue 6
Dynamics of Energy Transfer in Peptide−Surface Collisions
journal, February 2002
- Meroueh, Oussama; Hase, William L.
- Journal of the American Chemical Society, Vol. 124, Issue 7
Collisional activation of peptide ions in FT-ICR mass spectrometry
journal, January 2003
- Laskin, Julia; Futrell, Jean H.
- Mass Spectrometry Reviews, Vol. 22, Issue 3
High pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry for minimization of ganglioside fragmentation
journal, April 2002
- O’Connor, Peter B.; Mirgorodskaya, Ekaterina; Costello, Catherine E.
- Journal of the American Society for Mass Spectrometry, Vol. 13, Issue 4
A novel ion funnel for focusing ions at elevated pressure using electrospray ionization mass spectrometry
journal, October 1997
- Schaffer, Scott A.; Tang, Keqi; Anderson, Gordon A.
- Rapid Communications in Mass Spectrometry, Vol. 11, Issue 16, p. 1813-1817
Low energy collision induced dissociation: phase-shifting excitation control of ion kinetic energy in ion cyclotron resonance spectrometry
journal, September 1992
- Boering, Kristie A.; Rolfe, Joseph; Brauman, John I.
- International Journal of Mass Spectrometry and Ion Processes, Vol. 117
Dissociative scattering of polyatomic ions from a liquid surface: CF3+ on a perfluoropolyether film
journal, December 1997
- Koppers, Wim R.; Beijersbergen, Jaap H. M.; Weeding, Tina L.
- The Journal of Chemical Physics, Vol. 107, Issue 24
Surface-Induced Dissociation of Multiply-Protonated Proteins
journal, March 1995
- Chorush, Russell A.; Little, Daniel P.; Beu, Steven C.
- Analytical Chemistry, Vol. 67, Issue 6
Surface impact induced shattering of C6. Detection of small Cm fragments by negative surface ionization
journal, August 1996
- Beck, Rainer D.; Warth, Carmen; May, Klaus
- Chemical Physics Letters, Vol. 257, Issue 5-6
Preferential Fragmentation of Protonated Gas-Phase Peptide Ions Adjacent to Acidic Amino Acid Residues
journal, May 1995
- Qin, Jun; Chait, Brian T.
- Journal of the American Chemical Society, Vol. 117, Issue 19
Reactions of ions with organic surfaces
journal, November 1994
- Cooks, R. G.; Ast, T.; Pradeep, T.
- Accounts of Chemical Research, Vol. 27, Issue 11
“Linearizing” an ion cyclotron resonance cell
journal, December 2002
- Barlow, S. E.; Tinkle, Mark D.
- Review of Scientific Instruments, Vol. 73, Issue 12
Identification of the facile gas-phase cleavage of the Asp-Pro and Asp-Xxx peptide bonds in matrix-assisted laser desorption time-of-flight mass spectrometry
journal, November 1993
- Yu, Wen.; Vath, James E.; Huberty, Michael C.
- Analytical Chemistry, Vol. 65, Issue 21
Surface-Induced Dissociation in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: Instrument Design and Evaluation
journal, July 2002
- Laskin, Julia; Denisov, Eduard V.; Shukla, Anil K.
- Analytical Chemistry, Vol. 74, Issue 14
A high pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry ion source for thermal stabilization of labile biomolecules
journal, January 2001
- O'Connor, Peter B.; Costello, Catherine E.
- Rapid Communications in Mass Spectrometry, Vol. 15, Issue 19
Energy transfer in collisions of peptide ions with surfaces
journal, August 2003
- Laskin, Julia; Futrell, Jean H.
- The Journal of Chemical Physics, Vol. 119, Issue 6
Surface-induced Dissociation: An Effective Tool to Probe Structure, Energetics and Fragmentation Mechanisms of Protonated Peptides
journal, April 1996
- Dongré, Ashok R.; Somogyi, Árpád; Wysocki, Vicki H.
- Journal of Mass Spectrometry, Vol. 31, Issue 4, p. 339-350