Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies
Abstract
A technique for measuring broadband near-infrared absorption spectra of turbid media that uses a combination of frequency-domain and steady-state reflectance methods. Most of the wavelength coverage is provided by a white-light steady-state measurement, whereas the frequency-domain data are acquired at a few selected wavelengths. Coefficients of absorption and reduced scattering derived from the frequency-domain data are used to calibrate the intensity of the steady-state measurements and to determine the reduced scattering coefficient at all wavelengths in the spectral window of interest. The absorption coefficient spectrum is determined by comparing the steady-state reflectance values with the predictions of diffusion theory, wavelength by wavelength. Absorption spectra of a turbid phantom and of human breast tissue in vivo, derived with the combined frequency-domain and steady-state technique, agree well with expected reference values.
- Inventors:
-
- Irvine, CA
- Rochester, NY
- Lake Forest, CA
- Costa Mesa, CA
- Issue Date:
- Research Org.:
- Univ. of California (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 984515
- Patent Number(s):
- 7428434
- Application Number:
- 10/191,693
- Assignee:
- The Regents of the Univeristy of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
- DOE Contract Number:
- FG03-91ER61227
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Tromberg, Bruce J, Berger, Andrew J, Cerussi, Albert E, Bevilacqua, Frederic, and Jakubowski, Dorota. Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies. United States: N. p., 2008.
Web.
Tromberg, Bruce J, Berger, Andrew J, Cerussi, Albert E, Bevilacqua, Frederic, & Jakubowski, Dorota. Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies. United States.
Tromberg, Bruce J, Berger, Andrew J, Cerussi, Albert E, Bevilacqua, Frederic, and Jakubowski, Dorota. Tue .
"Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies". United States. https://www.osti.gov/servlets/purl/984515.
@article{osti_984515,
title = {Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies},
author = {Tromberg, Bruce J and Berger, Andrew J and Cerussi, Albert E and Bevilacqua, Frederic and Jakubowski, Dorota},
abstractNote = {A technique for measuring broadband near-infrared absorption spectra of turbid media that uses a combination of frequency-domain and steady-state reflectance methods. Most of the wavelength coverage is provided by a white-light steady-state measurement, whereas the frequency-domain data are acquired at a few selected wavelengths. Coefficients of absorption and reduced scattering derived from the frequency-domain data are used to calibrate the intensity of the steady-state measurements and to determine the reduced scattering coefficient at all wavelengths in the spectral window of interest. The absorption coefficient spectrum is determined by comparing the steady-state reflectance values with the predictions of diffusion theory, wavelength by wavelength. Absorption spectra of a turbid phantom and of human breast tissue in vivo, derived with the combined frequency-domain and steady-state technique, agree well with expected reference values.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {9}
}
Works referenced in this record:
Improved solutions of the steady-state and the time-resolved diffusion equations for reflectance from a semi-infinite turbid medium
journal, January 1997
- Kienle, Alwin; Patterson, Michael S.
- Journal of the Optical Society of America A, Vol. 14, Issue 1