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Title: Acoustic monitoring method and system in laser-induced optical breakdown (LIOB)

Abstract

An acoustic monitoring method and system in laser-induced optical breakdown (LIOB) provides information which characterize material which is broken down, microbubbles in the material, and/or the microenvironment of the microbubbles. In one embodiment of the invention, femtosecond laser pulses are focused just inside the surface of a volume of aqueous solution which may include dendrimer nanocomposite (DNC) particles. A tightly focused, high frequency, single-element ultrasonic transducer is positioned such that its focus coincides axially and laterally with this laser focus. When optical breakdown occurs, a microbubble forms and a shock or pressure wave is emitted (i.e., acoustic emission). In addition to this acoustic signal, the microbubble may be actively probed with pulse-echo measurements from the same transducer. After the microbubble forms, received pulse-echo signals have an extra pulse, describing the microbubble location and providing a measure of axial microbubble size. Wavefield plots of successive recordings illustrate the generation, growth, and collapse of microbubbles due to optical breakdown. These same plots can also be used to quantify LIOB thresholds.

Inventors:
 [1];  [1];  [2];  [3];  [1];  [1];  [1];  [4]
  1. Ann Arbor, MI
  2. Dexter, MI
  3. (Ann Arbor, MI)
  4. Fenton, MI
Issue Date:
Research Org.:
Univ. of Michigan, Ann Arbor, MI (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
984344
Patent Number(s):
7367948
Application Number:
10/643,659
Assignee:
The Regents of the University of Michigan (Ann Arbor, MI)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
DOE Contract Number:  
FG01-00NE22943
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

O'Donnell, Matthew, Ye, Jing Yong, Norris, Theodore B, Baker, Jr., James R., Balogh, Lajos P, Milas, Susanne M, Emelianov, Stanislav Y, and Hollman, Kyle W. Acoustic monitoring method and system in laser-induced optical breakdown (LIOB). United States: N. p., 2008. Web.
O'Donnell, Matthew, Ye, Jing Yong, Norris, Theodore B, Baker, Jr., James R., Balogh, Lajos P, Milas, Susanne M, Emelianov, Stanislav Y, & Hollman, Kyle W. Acoustic monitoring method and system in laser-induced optical breakdown (LIOB). United States.
O'Donnell, Matthew, Ye, Jing Yong, Norris, Theodore B, Baker, Jr., James R., Balogh, Lajos P, Milas, Susanne M, Emelianov, Stanislav Y, and Hollman, Kyle W. Tue . "Acoustic monitoring method and system in laser-induced optical breakdown (LIOB)". United States. https://www.osti.gov/servlets/purl/984344.
@article{osti_984344,
title = {Acoustic monitoring method and system in laser-induced optical breakdown (LIOB)},
author = {O'Donnell, Matthew and Ye, Jing Yong and Norris, Theodore B and Baker, Jr., James R. and Balogh, Lajos P and Milas, Susanne M and Emelianov, Stanislav Y and Hollman, Kyle W},
abstractNote = {An acoustic monitoring method and system in laser-induced optical breakdown (LIOB) provides information which characterize material which is broken down, microbubbles in the material, and/or the microenvironment of the microbubbles. In one embodiment of the invention, femtosecond laser pulses are focused just inside the surface of a volume of aqueous solution which may include dendrimer nanocomposite (DNC) particles. A tightly focused, high frequency, single-element ultrasonic transducer is positioned such that its focus coincides axially and laterally with this laser focus. When optical breakdown occurs, a microbubble forms and a shock or pressure wave is emitted (i.e., acoustic emission). In addition to this acoustic signal, the microbubble may be actively probed with pulse-echo measurements from the same transducer. After the microbubble forms, received pulse-echo signals have an extra pulse, describing the microbubble location and providing a measure of axial microbubble size. Wavefield plots of successive recordings illustrate the generation, growth, and collapse of microbubbles due to optical breakdown. These same plots can also be used to quantify LIOB thresholds.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {5}
}

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Works referenced in this record:

Acoustic detection of laser induced optical breakdown in dendrimer nanocomposites: implications for site targeted molecular diagnostics and therapeutics
conference, January 2002


Role of Laser-Induced Plasma Formation in Pulsed Cellular Microsurgery and Micromanipulation
journal, February 2002


Acoustic detection of microbubble formation induced by enhanced optical breakdown of silver/dendrimer nanocomposites
journal, February 2003


Behavior of laser-induced cavitation bubbles in liquid nitrogen
journal, November 2000


Enhancement of laser-induced optical breakdown using metal/dendrimer nanocomposites
journal, March 2002


Influence of pulse duration on mechanical effects after laser-induced breakdown in water
journal, June 1998


Optical and Acoustical Dynamics of Microbubble Contrast Agents inside Neutrophils
journal, March 2001