Detection and recognition of analytes based on their crystallization patterns
Abstract
The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as "crystallization pattern") containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. It has been shown that changes in the crystallization patterns of a number of amino-acids can be used as a "signature" of a protein added. It was also found that both the character of changer in the crystallization patter and the fact of such changes can be used as recognition elements in analysis of protein molecules.
- Inventors:
-
- Manassas, VA
- Cross Junction, VA
- Kensington, MD
- Issue Date:
- Research Org.:
- George Mason Univ., Fairfax, VA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 984342
- Patent Number(s):
- 7368288
- Application Number:
- 11/397,908
- Assignee:
- George Mason Intellectual Properties, Inc. (Fairfax, VA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C30 - CRYSTAL GROWTH C30B - SINGLE-CRYSTAL-GROWTH
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- DOE Contract Number:
- FC52-04NA25455
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Morozov, Victor, Bailey, Charles L, Vsevolodov, Nikolai N, and Elliott, Adam. Detection and recognition of analytes based on their crystallization patterns. United States: N. p., 2008.
Web.
Morozov, Victor, Bailey, Charles L, Vsevolodov, Nikolai N, & Elliott, Adam. Detection and recognition of analytes based on their crystallization patterns. United States.
Morozov, Victor, Bailey, Charles L, Vsevolodov, Nikolai N, and Elliott, Adam. Tue .
"Detection and recognition of analytes based on their crystallization patterns". United States. https://www.osti.gov/servlets/purl/984342.
@article{osti_984342,
title = {Detection and recognition of analytes based on their crystallization patterns},
author = {Morozov, Victor and Bailey, Charles L and Vsevolodov, Nikolai N and Elliott, Adam},
abstractNote = {The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as "crystallization pattern") containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. It has been shown that changes in the crystallization patterns of a number of amino-acids can be used as a "signature" of a protein added. It was also found that both the character of changer in the crystallization patter and the fact of such changes can be used as recognition elements in analysis of protein molecules.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {5}
}
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