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Title: Detection and recognition of analytes based on their crystallization patterns

Abstract

The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as "crystallization pattern") containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. It has been shown that changes in the crystallization patterns of a number of amino-acids can be used as a "signature" of a protein added. It was also found that both the character of changer in the crystallization patter and the fact of such changes can be used as recognition elements in analysis of protein molecules.

Inventors:
 [1];  [2];  [3];  [1]
  1. Manassas, VA
  2. Cross Junction, VA
  3. Kensington, MD
Issue Date:
Research Org.:
George Mason University
Sponsoring Org.:
USDOE
OSTI Identifier:
984342
Patent Number(s):
7,368,288
Application Number:
11/397,908
Assignee:
George Mason Intellectual Properties, Inc. (Fairfax, VA) NNSASC
DOE Contract Number:  
FC52-04NA25455
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Morozov, Victor, Bailey, Charles L, Vsevolodov, Nikolai N, and Elliott, Adam. Detection and recognition of analytes based on their crystallization patterns. United States: N. p., 2008. Web.
Morozov, Victor, Bailey, Charles L, Vsevolodov, Nikolai N, & Elliott, Adam. Detection and recognition of analytes based on their crystallization patterns. United States.
Morozov, Victor, Bailey, Charles L, Vsevolodov, Nikolai N, and Elliott, Adam. Tue . "Detection and recognition of analytes based on their crystallization patterns". United States. https://www.osti.gov/servlets/purl/984342.
@article{osti_984342,
title = {Detection and recognition of analytes based on their crystallization patterns},
author = {Morozov, Victor and Bailey, Charles L and Vsevolodov, Nikolai N and Elliott, Adam},
abstractNote = {The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as "crystallization pattern") containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. It has been shown that changes in the crystallization patterns of a number of amino-acids can be used as a "signature" of a protein added. It was also found that both the character of changer in the crystallization patter and the fact of such changes can be used as recognition elements in analysis of protein molecules.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {5}
}

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