Title: Permeabilizing biofilms

Abstract

Methods for permeabilizing biofilms using stress waves are described. The methods involve applying one or more stress waves to a biofilm, e.g., on a surface of a device or food item, or on a tissue surface in a patient, and then inducing stress waves to create transient increases in the permeability of the biofilm. The increased permeability facilitates delivery of compounds, such as antimicrobial or therapeutic agents into and through the biofilm.

Inventors:

Soukos, Nikolaos S ^[1]; Lee, Shun ^[2]; Doukas, Apostolos G ^[3]

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+ Show Inventor Affiliations

1. Revere, MA
2. Arlington, VA
3. Belmont, MA

Issue Date:

2008-02-19

Research Org.:

Massachusetts General Hospital

Sponsoring Org.:

USDOE

OSTI Identifier:

983901

Patent Number(s):

7332200

Application Number:

s 10/019,837

Assignee:

The General Hospital Corporation (Boston, MA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A01 - AGRICULTURE A01N - PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF

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A - HUMAN NECESSITIES A01 - AGRICULTURE A01N - PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF

A01N25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, {e.g. seed treatment or sequential application

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DOE Contract Number:  

FG02-91ER61228

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

36 MATERIALS SCIENCE