DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Mutator gene and hereditary non-polyposis colorectal cancer

Abstract

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

Inventors:
 [1];  [2];  [2]
  1. Helsingfors, FI
  2. Baltimore, MD
Issue Date:
Research Org.:
ELEANOR ROOSEVELT INSTITUTE
Sponsoring Org.:
USDOE
OSTI Identifier:
983105
Patent Number(s):
7326778
Application Number:
08/160,295
Assignee:
The John Hopkins University (Baltimore, MD)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
FG02-91ER61139
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Mutator gene and hereditary non-polyposis colorectal cancer. United States: N. p., 2008. Web.
de la Chapelle, Albert, Vogelstein, Bert, & Kinzler, Kenneth W. Mutator gene and hereditary non-polyposis colorectal cancer. United States.
de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Tue . "Mutator gene and hereditary non-polyposis colorectal cancer". United States. https://www.osti.gov/servlets/purl/983105.
@article{osti_983105,
title = {Mutator gene and hereditary non-polyposis colorectal cancer},
author = {de la Chapelle, Albert and Vogelstein, Bert and Kinzler, Kenneth W},
abstractNote = {The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {2}
}

Works referenced in this record:

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
journal, December 1993


Microsatellite instability in cancer of the proximal colon
journal, May 1993


Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
journal, September 1993


Hypermutability and mismatch repair deficiency in RER+ tumor cells
journal, December 1993


Genetic mapping of a locus predisposing to human colorectal cancer
journal, May 1993


The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
journal, December 1993


Clues to the pathogenesis of familial colorectal cancer
journal, May 1993


Slippery DNA and diseases
journal, September 1993


Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
journal, June 1993