Mutator gene and hereditary non-polyposis colorectal cancer
Abstract
The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.
- Inventors:
-
- Helsingfors, FI
- Baltimore, MD
- Issue Date:
- Research Org.:
- ELEANOR ROOSEVELT INSTITUTE
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 983105
- Patent Number(s):
- 7326778
- Application Number:
- 08/160,295
- Assignee:
- The John Hopkins University (Baltimore, MD)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- FG02-91ER61139
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Mutator gene and hereditary non-polyposis colorectal cancer. United States: N. p., 2008.
Web.
de la Chapelle, Albert, Vogelstein, Bert, & Kinzler, Kenneth W. Mutator gene and hereditary non-polyposis colorectal cancer. United States.
de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Tue .
"Mutator gene and hereditary non-polyposis colorectal cancer". United States. https://www.osti.gov/servlets/purl/983105.
@article{osti_983105,
title = {Mutator gene and hereditary non-polyposis colorectal cancer},
author = {de la Chapelle, Albert and Vogelstein, Bert and Kinzler, Kenneth W},
abstractNote = {The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 05 00:00:00 EST 2008},
month = {Tue Feb 05 00:00:00 EST 2008}
}
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