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Title: Targeted polypeptide degradation

Abstract

This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.

Inventors:
 [1];  [1]
  1. Brookline, MA
Issue Date:
Research Org.:
Harvard University
Sponsoring Org.:
USDOE
OSTI Identifier:
983006
Patent Number(s):
7371539
Application Number:
11/003,103
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
FG02-87ER60565
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Church, George M, and Janse, Daniel M. Targeted polypeptide degradation. United States: N. p., 2008. Web.
Church, George M, & Janse, Daniel M. Targeted polypeptide degradation. United States.
Church, George M, and Janse, Daniel M. Tue . "Targeted polypeptide degradation". United States. https://www.osti.gov/servlets/purl/983006.
@article{osti_983006,
title = {Targeted polypeptide degradation},
author = {Church, George M and Janse, Daniel M},
abstractNote = {This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {5}
}

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