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Title: Identification of M-CSF agonists and antagonists

Abstract

The present invention is directed to methods for crystallizing macrophage colony stimulating factor. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.

Inventors:
 [1];  [2];  [3];  [4];  [5];  [6];  [6];  [7];  [8]
+ Show Inventor Affiliations
  1. Mystic, CT
  2. Walnut Creek, CA
  3. Moraga, CA
  4. El Cerrito, CA
  5. San Rafael, CA
  6. Oakland, CA
  7. Martinez, CA
  8. Armonk, NY
Issue Date:
Research Org.:
Univ. of California (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
982807
Patent Number(s):
6025146
Application Number:
08/462,069
Assignee:
Chiron Corporation (Emeryville, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Pandit, Jayvardhan, Jancarik, Jarmila, Kim, Sung-Hou, Koths, Kirston, Halenbeck, Robert, Fear, Anna Lisa, Taylor, Eric, Yamamoto, Ralph, and Bohm, Andrew. Identification of M-CSF agonists and antagonists. United States: N. p., 2000. Web.
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Pandit, Jayvardhan, Jancarik, Jarmila, Kim, Sung-Hou, Koths, Kirston, Halenbeck, Robert, Fear, Anna Lisa, Taylor, Eric, Yamamoto, Ralph, & Bohm, Andrew. Identification of M-CSF agonists and antagonists. United States.
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Pandit, Jayvardhan, Jancarik, Jarmila, Kim, Sung-Hou, Koths, Kirston, Halenbeck, Robert, Fear, Anna Lisa, Taylor, Eric, Yamamoto, Ralph, and Bohm, Andrew. Tue . "Identification of M-CSF agonists and antagonists". United States. https://www.osti.gov/servlets/purl/982807.
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@article{osti_982807,
title = {Identification of M-CSF agonists and antagonists},
author = {Pandit, Jayvardhan and Jancarik, Jarmila and Kim, Sung-Hou and Koths, Kirston and Halenbeck, Robert and Fear, Anna Lisa and Taylor, Eric and Yamamoto, Ralph and Bohm, Andrew},
abstractNote = {The present invention is directed to methods for crystallizing macrophage colony stimulating factor. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 15 00:00:00 EST 2000},
month = {Tue Feb 15 00:00:00 EST 2000}
}
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Works referenced in this record:

Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor
journal, November 1992

Australian Mutual Provident Society v 400 St Kilda Road Pty Ltd
journal, August 1989

Structure-function studies on recombinant human macrophage colony-stimulating factor (M-CSF).
journal, December 1994

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