Low pressure electrospray ionization system and process for effective transmission of ions

Tang, Keqi; Page, Jason S; Kelly, Ryan T; Smith, Richard D

Title: Low pressure electrospray ionization system and process for effective transmission of ions

Abstract

A system and method are disclosed that provide up to complete transmission of ions between coupled stages with low effective ion losses. A novel "interfaceless" electrospray ionization system is further described that operates the electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer.

Inventors:

Tang, Keqi ^[1]; Page, Jason S ^[2]; Kelly, Ryan T ^[3]; Smith, Richard D ^[1]

Richland, WA
Kennewick, WA
Wet Richland, WA

Issue Date:: 2010-03-02

Research Org.:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 978683

Patent Number(s):: 7671344

Application Number:: 11/848,884

Assignee:: Battelle Memorial Institute (Richland, WA)

Patent Classifications (CPCs):: H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

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H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/066 - {Ion funnels}
H01J49/165 - {Electrospray ionisation}

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DOE Contract Number:: AC05-76RL01830

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Tang, Keqi, Page, Jason S, Kelly, Ryan T, and Smith, Richard D. Low pressure electrospray ionization system and process for effective transmission of ions.  United States: N. p., 2010. 
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                    Tang, Keqi, Page, Jason S, Kelly, Ryan T, & Smith, Richard D. Low pressure electrospray ionization system and process for effective transmission of ions.  United States.

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                    Tang, Keqi, Page, Jason S, Kelly, Ryan T, and Smith, Richard D. Tue .  
        "Low pressure electrospray ionization system and process for effective transmission of ions".  United States.  https://www.osti.gov/servlets/purl/978683.

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@article{osti_978683,

  title        = {Low pressure electrospray ionization system and process for effective transmission of ions},

  author       = {Tang, Keqi and Page, Jason S and Kelly, Ryan T and Smith, Richard D},

  abstractNote = {A system and method are disclosed that provide up to complete transmission of ions between coupled stages with low effective ion losses. A novel "interfaceless" electrospray ionization system is further described that operates the electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2010},

  month        = {3}

}

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Works referenced in this record:

IMS−IMS and IMS−IMS−IMS/MS for Separating Peptide and Protein Fragment Ions
journal, April 2006

Merenbloom, Samuel I.; Koeniger, Stormy L.; Valentine, Stephen J.
Analytical Chemistry, Vol. 78, Issue 8
https://doi.org/10.1021/ac052208e

Ionization and transmission efficiency in an electrospray ionization—mass spectrometry interface
journal, September 2007

Page, Jason S.; Kelly, Ryan T.; Tang, Keqi
Journal of the American Society for Mass Spectrometry, Vol. 18, Issue 9, p. 1582-1590
https://doi.org/10.1016/j.jasms.2007.05.018

Energy distribution and spatial structure of electrosprays of ionic liquids in vacuo
journal, February 2004

Romero-Sanz, I.; Fernandez de la Mora, J.
Journal of Applied Physics, Vol. 95, Issue 4
https://doi.org/10.1063/1.1639947

Charged droplet experiments
journal, March 1962

Hendricks, Charles D.
Journal of Colloid Science, Vol. 17, Issue 3
https://doi.org/10.1016/0095-8522(62)90040-5

On the current emitted by Taylor cone-jets of electrolytes in vacuo: Implications for liquid metal ion sources
journal, March 1998

Gamero-Castaño, M.; Aguirre-de-Carcer, I.; de Juan, L.
Journal of Applied Physics, Vol. 83, Issue 5
https://doi.org/10.1063/1.367002

Effect of Background Gas on the Current Emitted from Taylor Cones
journal, May 1995

Aguirre-de-Carcer, I.; de la Mora, J. Fernández
Journal of Colloid and Interface Science, Vol. 171, Issue 2
https://doi.org/10.1006/jcis.1995.1210

Generation of Multiple Electrosprays Using Microfabricated Emitter Arrays for Improved Mass Spectrometric Sensitivity
journal, April 2001

Tang, Keqi; Lin, Yuehe; Matson, Dean W.
Analytical Chemistry, Vol. 73, Issue 8
https://doi.org/10.1021/ac001191r

Electrohydrodynamic mass spectrometry
journal, January 1986

Cook, Kelsey D.
Mass Spectrometry Reviews, Vol. 5, Issue 4
https://doi.org/10.1002/mas.1280050404

Array of Chemically Etched Fused-Silica Emitters for Improving the Sensitivity and Quantitation of Electrospray Ionization Mass Spectrometry
journal, June 2007

Kelly, Ryan T.; Page, Jason S.; Tang, Keqi
Analytical Chemistry, Vol. 79, Issue 11
https://doi.org/10.1021/ac062417e

Improving mass spectrometer sensitivity using a high-pressure electrodynamic ion funnel interface
journal, September 2006

Ibrahim, Yehia; Tang, Keqi; Tolmachev, Aleksey V.
Journal of the American Society for Mass Spectrometry, Vol. 17, Issue 9, p. 1299-1305
https://doi.org/10.1016/j.jasms.2006.06.005

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Title: Low pressure electrospray ionization system and process for effective transmission of ions

Abstract

Citation Formats

IMS−IMS and IMS−IMS−IMS/MS for Separating Peptide and Protein Fragment Ions journal, April 2006

Ionization and transmission efficiency in an electrospray ionization—mass spectrometry interface journal, September 2007

Energy distribution and spatial structure of electrosprays of ionic liquids in vacuo journal, February 2004

Charged droplet experiments journal, March 1962

On the current emitted by Taylor cone-jets of electrolytes in vacuo: Implications for liquid metal ion sources journal, March 1998

Effect of Background Gas on the Current Emitted from Taylor Cones journal, May 1995

Generation of Multiple Electrosprays Using Microfabricated Emitter Arrays for Improved Mass Spectrometric Sensitivity journal, April 2001

Electrohydrodynamic mass spectrometry journal, January 1986

Array of Chemically Etched Fused-Silica Emitters for Improving the Sensitivity and Quantitation of Electrospray Ionization Mass Spectrometry journal, June 2007

Improving mass spectrometer sensitivity using a high-pressure electrodynamic ion funnel interface journal, September 2006

IMS−IMS and IMS−IMS−IMS/MS for Separating Peptide and Protein Fragment Ions
journal, April 2006

Ionization and transmission efficiency in an electrospray ionization—mass spectrometry interface
journal, September 2007

Energy distribution and spatial structure of electrosprays of ionic liquids in vacuo
journal, February 2004

Charged droplet experiments
journal, March 1962

On the current emitted by Taylor cone-jets of electrolytes in vacuo: Implications for liquid metal ion sources
journal, March 1998

Effect of Background Gas on the Current Emitted from Taylor Cones
journal, May 1995

Generation of Multiple Electrosprays Using Microfabricated Emitter Arrays for Improved Mass Spectrometric Sensitivity
journal, April 2001

Electrohydrodynamic mass spectrometry
journal, January 1986

Array of Chemically Etched Fused-Silica Emitters for Improving the Sensitivity and Quantitation of Electrospray Ionization Mass Spectrometry
journal, June 2007

Improving mass spectrometer sensitivity using a high-pressure electrodynamic ion funnel interface
journal, September 2006