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Title: Flow method and apparatus for screening chemicals using micro x-ray fluorescence

Abstract

Method and apparatus for screening chemicals using micro x-ray fluorescence. A method for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder involves flow-separating a solution of chemicals and target binders into separated components, exposing them to an x-ray excitation beam, detecting x-ray fluorescence signals from the components, and determining from the signals whether or not a binding event between a chemical and target binder has occurred.

Inventors:
 [1];  [1];  [2];  [1];  [1];  [1]
  1. Los Alamos, NM
  2. Bartlesville, OK
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
972296
Patent Number(s):
7519145
Application Number:
11/444,660
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Warner, Benjamin P, Havrilla, George J, Miller, Thomasin C, Lewis, Cris, Mahan, Cynthia A, and Wells, Cyndi A. Flow method and apparatus for screening chemicals using micro x-ray fluorescence. United States: N. p., 2009. Web.
Warner, Benjamin P, Havrilla, George J, Miller, Thomasin C, Lewis, Cris, Mahan, Cynthia A, & Wells, Cyndi A. Flow method and apparatus for screening chemicals using micro x-ray fluorescence. United States.
Warner, Benjamin P, Havrilla, George J, Miller, Thomasin C, Lewis, Cris, Mahan, Cynthia A, and Wells, Cyndi A. Tue . "Flow method and apparatus for screening chemicals using micro x-ray fluorescence". United States. https://www.osti.gov/servlets/purl/972296.
@article{osti_972296,
title = {Flow method and apparatus for screening chemicals using micro x-ray fluorescence},
author = {Warner, Benjamin P and Havrilla, George J and Miller, Thomasin C and Lewis, Cris and Mahan, Cynthia A and Wells, Cyndi A},
abstractNote = {Method and apparatus for screening chemicals using micro x-ray fluorescence. A method for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder involves flow-separating a solution of chemicals and target binders into separated components, exposing them to an x-ray excitation beam, detecting x-ray fluorescence signals from the components, and determining from the signals whether or not a binding event between a chemical and target binder has occurred.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {4}
}

Patent:

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