Methods for improved selectivity in photo-activation and detection of molecular diagnostic agents
Abstract
A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method comprises the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention also provides a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.
- Inventors:
-
- Oak Ridge, TN
- Knoxville, TN
- Issue Date:
- Research Org.:
- Lockheed Martin Energy Systems, Inc.
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 970385
- Patent Number(s):
- 7346387
- Application Number:
- 09/072,963
- Assignee:
- Provectus Devicetech, Inc. (Knoxville, TN)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- AC05-84OR21400
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Wachter, Eric A, Fisher, Walter G, and Dees, H Craig. Methods for improved selectivity in photo-activation and detection of molecular diagnostic agents. United States: N. p., 2008.
Web.
Wachter, Eric A, Fisher, Walter G, & Dees, H Craig. Methods for improved selectivity in photo-activation and detection of molecular diagnostic agents. United States.
Wachter, Eric A, Fisher, Walter G, and Dees, H Craig. Tue .
"Methods for improved selectivity in photo-activation and detection of molecular diagnostic agents". United States. https://www.osti.gov/servlets/purl/970385.
@article{osti_970385,
title = {Methods for improved selectivity in photo-activation and detection of molecular diagnostic agents},
author = {Wachter, Eric A and Fisher, Walter G and Dees, H Craig},
abstractNote = {A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method comprises the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention also provides a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {3}
}
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