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Title: Structure-based receptor MIMICS targeted against bacterial superantigen toxins

Abstract

The invention provides therapeutic compositions useful in the treatment of bacterial superantigen mediated conditions, such as Toxic Shock Syndrome. The compositions comprise genetically engineered bifunctional polypeptides containing a specific T-cell receptor binding domain and a specific MHC class II receptor binding domain, each targeting non-overlapping epitopes on a superantigen molecule against which they are designed. The anti-superantigen "receptor mimetics" or "chimeras" are rationally designed to recreate the modality of superantigen binding directly to both the TCR and the MHC-II receptor, and are capable of acting as decoys for superantigen binding, effectively out-competing the host T-cell and MHC-II receptors, the natural host receptors.

Inventors:
 [1];  [2];  [2];  [3]
  1. Santa Fe, NM
  2. Los Alamos, NM
  3. Albuquerque, NM
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
968328
Patent Number(s):
7576183
Application Number:
10/746,959
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Gupta, Goutam, Hong-Geller, Elizabeth, Shiflett, Patrick R, and Lehnert, Nancy M. Structure-based receptor MIMICS targeted against bacterial superantigen toxins. United States: N. p., 2009. Web.
Gupta, Goutam, Hong-Geller, Elizabeth, Shiflett, Patrick R, & Lehnert, Nancy M. Structure-based receptor MIMICS targeted against bacterial superantigen toxins. United States.
Gupta, Goutam, Hong-Geller, Elizabeth, Shiflett, Patrick R, and Lehnert, Nancy M. Tue . "Structure-based receptor MIMICS targeted against bacterial superantigen toxins". United States. https://www.osti.gov/servlets/purl/968328.
@article{osti_968328,
title = {Structure-based receptor MIMICS targeted against bacterial superantigen toxins},
author = {Gupta, Goutam and Hong-Geller, Elizabeth and Shiflett, Patrick R and Lehnert, Nancy M},
abstractNote = {The invention provides therapeutic compositions useful in the treatment of bacterial superantigen mediated conditions, such as Toxic Shock Syndrome. The compositions comprise genetically engineered bifunctional polypeptides containing a specific T-cell receptor binding domain and a specific MHC class II receptor binding domain, each targeting non-overlapping epitopes on a superantigen molecule against which they are designed. The anti-superantigen "receptor mimetics" or "chimeras" are rationally designed to recreate the modality of superantigen binding directly to both the TCR and the MHC-II receptor, and are capable of acting as decoys for superantigen binding, effectively out-competing the host T-cell and MHC-II receptors, the natural host receptors.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {8}
}

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