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Title: Apparatus and method for concentrating and filtering particles suspended in a fluid

Abstract

Disclosed is a device for separating and concentrating particles suspended in a fluid stream by using dielectrophoresis (DEP) to trap and/or deflect those particles as they migrate through a fluid channel. The method uses fluid channels designed to constrain a liquid flowing through it to uniform electrokinetic flow velocities. This behavior is achieved by connecting deep and shallow sections of channels, with the channel depth varying abruptly along an interface. By careful design of abrupt changes in specific permeability at the interface, an abrupt and spatially uniform change in electrokinetic force can be selected. Because these abrupt interfaces also cause a sharp gradient in applied electric fields, a DEP force also can be established along the interface. Depending on the complex conductivity of the suspended particles and the immersion liquid, the DEP force can controllably complement or oppose the local electrokinetic force transporting the fluid through the channel allowing for manipulation of particles suspended in the transporting liquid.

Inventors:
 [1];  [2];  [3]
  1. Bethesda, MD
  2. Livermore, CA
  3. Danville, CA
Issue Date:
Research Org.:
Sandia National Lab. (SNL-CA), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
963815
Patent Number(s):
7534334
Application Number:
10/956,446
Assignee:
Sandia Corporation (Livermore, CA)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Fiechtner, Gregory J, Cummings, Eric B, and Singh, Anup K. Apparatus and method for concentrating and filtering particles suspended in a fluid. United States: N. p., 2009. Web.
Fiechtner, Gregory J, Cummings, Eric B, & Singh, Anup K. Apparatus and method for concentrating and filtering particles suspended in a fluid. United States.
Fiechtner, Gregory J, Cummings, Eric B, and Singh, Anup K. Tue . "Apparatus and method for concentrating and filtering particles suspended in a fluid". United States. https://www.osti.gov/servlets/purl/963815.
@article{osti_963815,
title = {Apparatus and method for concentrating and filtering particles suspended in a fluid},
author = {Fiechtner, Gregory J and Cummings, Eric B and Singh, Anup K},
abstractNote = {Disclosed is a device for separating and concentrating particles suspended in a fluid stream by using dielectrophoresis (DEP) to trap and/or deflect those particles as they migrate through a fluid channel. The method uses fluid channels designed to constrain a liquid flowing through it to uniform electrokinetic flow velocities. This behavior is achieved by connecting deep and shallow sections of channels, with the channel depth varying abruptly along an interface. By careful design of abrupt changes in specific permeability at the interface, an abrupt and spatially uniform change in electrokinetic force can be selected. Because these abrupt interfaces also cause a sharp gradient in applied electric fields, a DEP force also can be established along the interface. Depending on the complex conductivity of the suspended particles and the immersion liquid, the DEP force can controllably complement or oppose the local electrokinetic force transporting the fluid through the channel allowing for manipulation of particles suspended in the transporting liquid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {5}
}

Works referenced in this record:

Fluorescent Liposome Flow Markers for Microscale Particle-Image Velocimetry
journal, March 2001


Dielectrophoretic Concentration and Separation of Live and Dead Bacteria in an Array of Insulators
journal, March 2004


Faceted Design of Channels for Low-Dispersion Electrokinetic Flows in Microfluidic Systems
journal, September 2003


Dielectrophoresis in Microchips Containing Arrays of Insulating Posts:  Theoretical and Experimental Results
journal, September 2003


Dielectrophoretic filter for separation and recovery of biological cells in water
journal, September 2003


An Investigation of High Gradient Dielectrophoretic Filtration
journal, September 2003


Low-dispersion electrokinetic flows for expanded separation channels in microfluidic systems:
journal, February 2004


Insulator-based dielectrophoresis for the selective concentration and separation of live bacteria in water
journal, June 2004