Title: Microfluidic microarray systems and methods thereof

Abstract

Disclosed are systems that include a manifold in fluid communication with a microfluidic chip having a microarray, an illuminator, and a detector in optical communication with the microarray. Methods for using these systems for biological detection are also disclosed.

Inventors:

West, Jay A. A. ^[1]; Hukari, Kyle W ^[2]; Hux, Gary A ^[3]

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+ Show Inventor Affiliations

1. Castro Valley, CA
2. San Ramon, CA
3. Tracy, CA

Issue Date:

2009-04-28

Research Org.:

Sandia National Lab. (SNL-CA), Livermore, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

963793

Patent Number(s):

7524672

Application Number:

10/946,920

Assignee:

Sandia Corporation (Livermore, CA)

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

B01J2219/00387 - Applications using probes
B01J2219/00527 - Sheets
B01J2219/00576 - fluorophore
B01J2219/00659 - Two-dimensional arrays
B01J2219/00722 - Nucleotides

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

B01L2200/027 - for microfluidic devices
B01L2200/10 - Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
B01L2300/0636 - Integrated biosensor, microarrays
B01L2300/0654 - Lenses
B01L2300/0877 - Flow chambers
B01L2300/18 - Means for temperature control
B01L2300/1894 - Cooling means
B01L2400/0487 - fluid pressure, pneumatics
B01L3/0293 - {for liquids}
B01L3/502715 - {characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces}
B01L3/565 - {Seals
B01L7/52 - {with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
B01L9/527 - {for microfluidic devices, e.g. used for lab-on-a-chip}

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/6837 - using probe arrays or probe chips
C12Q2565/629 - being a microfluidic device

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N21/0303 - {Optical path conditioning in cuvettes, e.g. windows

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DOE Contract Number:  

AC04-94AL85000

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

47 OTHER INSTRUMENTATION