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Title: Method and apparatus for selective filtering of ions

Abstract

An adjustable, low mass-to-charge (m/z) filter is disclosed employing electrospray ionization to block ions associated with unwanted low m/z species from entering the mass spectrometer and contributing their space charge to down-stream ion accumulation steps. The low-mass filter is made by using an adjustable potential energy barrier from the conductance limiting terminal electrode of an electrodynamic ion funnel, which prohibits species with higher ion mobilities from being transmitted. The filter provides a linear voltage adjustment of low-mass filtering from m/z values from about 50 to about 500. Mass filtering above m/z 500 can also be performed; however, higher m/z species are attenuated. The mass filter was evaluated with a liquid chromatography-mass spectrometry analysis of an albumin tryptic digest and resulted in the ability to block low-mass, "background" ions which account for 40-70% of the total ion current from the ESI source during peak elution.

Inventors:
 [1];  [2];  [2]
  1. Kennewick, WA
  2. Richland, WA
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
963725
Patent Number(s):
7514676
Application Number:
11/251,529
Assignee:
Battelle Memorial Insitute (Richland, WA)
Patent Classifications (CPCs):
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC05-76RLo1830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Page, Jason S, Tang, Keqi, and Smith, Richard D. Method and apparatus for selective filtering of ions. United States: N. p., 2009. Web.
Page, Jason S, Tang, Keqi, & Smith, Richard D. Method and apparatus for selective filtering of ions. United States.
Page, Jason S, Tang, Keqi, and Smith, Richard D. Tue . "Method and apparatus for selective filtering of ions". United States. https://www.osti.gov/servlets/purl/963725.
@article{osti_963725,
title = {Method and apparatus for selective filtering of ions},
author = {Page, Jason S and Tang, Keqi and Smith, Richard D},
abstractNote = {An adjustable, low mass-to-charge (m/z) filter is disclosed employing electrospray ionization to block ions associated with unwanted low m/z species from entering the mass spectrometer and contributing their space charge to down-stream ion accumulation steps. The low-mass filter is made by using an adjustable potential energy barrier from the conductance limiting terminal electrode of an electrodynamic ion funnel, which prohibits species with higher ion mobilities from being transmitted. The filter provides a linear voltage adjustment of low-mass filtering from m/z values from about 50 to about 500. Mass filtering above m/z 500 can also be performed; however, higher m/z species are attenuated. The mass filter was evaluated with a liquid chromatography-mass spectrometry analysis of an albumin tryptic digest and resulted in the ability to block low-mass, "background" ions which account for 40-70% of the total ion current from the ESI source during peak elution.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {4}
}

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Works referenced in this record:

Variable low-mass filtering using an electrodynamic ion funnel
journal, September 2005