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Title: Influenza sensor

Abstract

A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a trifunctional linker moiety with groups bonded thereto including (a) an alkyl chain adapted for attachment to a substrate, (b) a fluorescent moiety capable of generating a fluorescent signal, and (c) a recognition moiety having a spacer group of a defined length thereon, the recognition moiety capable of binding with tetrameric multivalent neuraminidase.

Inventors:
 [1];  [1];  [1];  [2];  [1]
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  1. Los Alamos, NM
  2. (Los Alamos, NM)
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
958675
Patent Number(s):
6627396
Application Number:
09/699,225
Assignee:
The Regents of the University of California (Los Alamos, NM)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
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DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Swanson, Basil I, Song, Xuedong, Unkefer, Clifford, Silks, III, Louis A., and Schmidt, Jurgen G. Influenza sensor. United States: N. p., 2003. Web.
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Swanson, Basil I, Song, Xuedong, Unkefer, Clifford, Silks, III, Louis A., & Schmidt, Jurgen G. Influenza sensor. United States.
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Swanson, Basil I, Song, Xuedong, Unkefer, Clifford, Silks, III, Louis A., and Schmidt, Jurgen G. Tue . "Influenza sensor". United States. https://www.osti.gov/servlets/purl/958675.
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@article{osti_958675,
title = {Influenza sensor},
author = {Swanson, Basil I and Song, Xuedong and Unkefer, Clifford and Silks, III, Louis A. and Schmidt, Jurgen G},
abstractNote = {A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a trifunctional linker moiety with groups bonded thereto including (a) an alkyl chain adapted for attachment to a substrate, (b) a fluorescent moiety capable of generating a fluorescent signal, and (c) a recognition moiety having a spacer group of a defined length thereon, the recognition moiety capable of binding with tetrameric multivalent neuraminidase.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {9}
}
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Works referenced in this record:

Guanidinobenzoic acid inhibitors of influenza virus neuraminidase 1 1Edited by R. Huber
journal, April 1997

Optical Signal Transduction Triggered by Protein−Ligand Binding:  Detection of Toxins Using Multivalent Binding
journal, May 1998

Supported Membranes: Scientific and Practical Applications
journal, January 1996

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