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Title: Membrane architectures for ion-channel switch-based electrochemical biosensors

Abstract

The present invention is directed to a process of forming a bilayer lipid membrane structure by depositing an organic layer having a defined surface area onto an electrically conductive substrate, removing portions of said organic layer upon said electrically conductive substrate whereby selected portions of said organic layer are removed to form defined voids within said defined surface area of said organic layer and defined islands of organic layer upon said electrically conductive substrate, and, depositing a bilayer lipid membrane over the defined voids and defined islands of organic layer upon said substrate whereby aqueous reservoirs are formed between said electrically conductive substrate and said bilayer lipid membrane, said bilayer lipid membrane characterized as spanning across the defined voids between said defined islands. A lipid membrane structure is also described together with an array of such lipid membrane structure.

Inventors:
 [1];  [1];  [1];  [2];  [3];  [4];  [2]
  1. Los Alamos, NM
  2. Davis, CA
  3. (Davis, CA)
  4. Woodland, CA
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
957014
Patent Number(s):
7442403
Application Number:
11/072,720
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Sansinena, Jose-Maria, Redondo, Antonio, Swanson, Basil I, Yee, Chanel Kitmon, Sapuri/Butti, Annapoorna R., Parikh, Atul N, and Yang, Calvin. Membrane architectures for ion-channel switch-based electrochemical biosensors. United States: N. p., 2008. Web.
Sansinena, Jose-Maria, Redondo, Antonio, Swanson, Basil I, Yee, Chanel Kitmon, Sapuri/Butti, Annapoorna R., Parikh, Atul N, & Yang, Calvin. Membrane architectures for ion-channel switch-based electrochemical biosensors. United States.
Sansinena, Jose-Maria, Redondo, Antonio, Swanson, Basil I, Yee, Chanel Kitmon, Sapuri/Butti, Annapoorna R., Parikh, Atul N, and Yang, Calvin. Tue . "Membrane architectures for ion-channel switch-based electrochemical biosensors". United States. https://www.osti.gov/servlets/purl/957014.
@article{osti_957014,
title = {Membrane architectures for ion-channel switch-based electrochemical biosensors},
author = {Sansinena, Jose-Maria and Redondo, Antonio and Swanson, Basil I and Yee, Chanel Kitmon and Sapuri/Butti, Annapoorna R. and Parikh, Atul N and Yang, Calvin},
abstractNote = {The present invention is directed to a process of forming a bilayer lipid membrane structure by depositing an organic layer having a defined surface area onto an electrically conductive substrate, removing portions of said organic layer upon said electrically conductive substrate whereby selected portions of said organic layer are removed to form defined voids within said defined surface area of said organic layer and defined islands of organic layer upon said electrically conductive substrate, and, depositing a bilayer lipid membrane over the defined voids and defined islands of organic layer upon said substrate whereby aqueous reservoirs are formed between said electrically conductive substrate and said bilayer lipid membrane, said bilayer lipid membrane characterized as spanning across the defined voids between said defined islands. A lipid membrane structure is also described together with an array of such lipid membrane structure.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {10}
}

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