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Title: Compositions and Methods for the Treatment of Pierce's Disease

Abstract

Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a surface recognition domain polypeptide, capable of binding to a bacterial membrane component, fused to a bacterial lysis domain polypeptide, capable of affecting lysis or rupture of the bacterial membrane, typically via a fused polypeptide linker. In particular, methods and compositions for the treatment or prevention of Pierce's disease of grapevines are provided. Methods for the generation of transgenic Vitus vinefera plants expressing xylem-secreted anti-microbial chimeras are also provided.

Inventors:
 [1]
  1. Santa Fe, NM
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
953732
Patent Number(s):
7432419
Application Number:
10/846,172
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
FG02-98ER62647, W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Gupta, Goutam. Compositions and Methods for the Treatment of Pierce's Disease. United States: N. p., 2008. Web.
Gupta, Goutam. Compositions and Methods for the Treatment of Pierce's Disease. United States.
Gupta, Goutam. Tue . "Compositions and Methods for the Treatment of Pierce's Disease". United States. https://www.osti.gov/servlets/purl/953732.
@article{osti_953732,
title = {Compositions and Methods for the Treatment of Pierce's Disease},
author = {Gupta, Goutam},
abstractNote = {Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a surface recognition domain polypeptide, capable of binding to a bacterial membrane component, fused to a bacterial lysis domain polypeptide, capable of affecting lysis or rupture of the bacterial membrane, typically via a fused polypeptide linker. In particular, methods and compositions for the treatment or prevention of Pierce's disease of grapevines are provided. Methods for the generation of transgenic Vitus vinefera plants expressing xylem-secreted anti-microbial chimeras are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {10}
}

Works referenced in this record:

Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice.
journal, May 1996


Fastidious Xylem-Limited Bacterial Plant Pathogens
journal, September 1996


Fate of Pierce's Disease Strains of Xylella fastidiosa in Common Riparian Plants in California
journal, September 1999


Evasion of host cell defense mechanisms by pathogenic bacteria
journal, February 2001


How do bacteria resist human antimicrobial peptides?
journal, April 2002


All-D amino acid-containing channel-forming antibiotic peptides.
journal, June 1990


Anthocyanins, catechins, condensed tannins and piceid production in Vitis vinifera cell bioreactor cultures
journal, June 1996


Production of antibodies in transgenic plants
journal, November 1989


Evolution of antibiotic resistance
journal, December 1997


Rapid, high-level expression of biologically active alpha-trichosanthin in transfected plants by an RNA viral vector.
journal, January 1993


Borrelia burgdorferi Are Susceptible to Killing by a Variety of Human Polymorphonuclear Leukocyte Components
journal, March 2002


Novel defensin subfamily from spinach ( Spinacia oleracea )
journal, September 1998


Ability of cecropin B to penetrate the enterobacterial outer membrane.
journal, October 1994


Expression and assembly of a full-length monoclonal antibody in plants using a plant virus vector
journal, November 1998


Antimicrobial Peptides from Plants
journal, January 1997


Genetic Diversity of Pierce's Disease Strains and Other Pathotypes of Xylella fastidiosa
journal, February 2001


Cell-free immunity in Cecropia. A model system for antibacterial proteins
journal, October 1991


Analyses of carbohydrate recognition by legume lectins: size of the combining site loops and their primary specificity
journal, March 1997


Mannose-binding plant lectins: Different structural scaffolds for a common sugar-recognition process
journal, July 2001


Plant defensins
journal, December 2002


Antibacterial peptides: basic facts and emerging concepts
journal, September 2003


Elastase Is the Only Human Neutrophil Granule Protein That Alone Is Responsible for In Vitro Killing of Borrelia burgdorferi
journal, April 1998


Transcriptional Profile of the Escherichia coli Response to the Antimicrobial Insect Peptide Cecropin A
journal, January 2003


Current status of defensins and their role in innate and adaptive immunity
journal, January 2002


Two-dimensional1H NMR study of recombinant insect defensin A in water: Resonance assignments, secondary structure and global folding
journal, May 1992


Pierce's Disease Bacterium: Mechanism of Transmission by Leafhopper Vectors
journal, November 1979


Pierce's Disease of Grapevines: Isolation of the Causal Bacterium
journal, January 1978


Xylella Fastidiosa: Xylem-Limited Bacterial Pathogen of Plants
journal, September 1989


Cationic peptides: effectors in innate immunity and novel antimicrobials
journal, October 2001


Diversity of antimicrobial peptides and their mechanisms of action
journal, December 1999


Immunization with a plant-produced colorectal cancer antigen
journal, February 2004