Biological preconcentrator
Abstract
A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies.
- Inventors:
-
- Albuquerque, NM
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 943499
- Patent Number(s):
- 7422724
- Application Number:
- 10/214,891
- Assignee:
- Sandia Corporation (Albuquerque, NM)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Manginell, Ronald P, Bunker, Bruce C, and Huber, Dale L. Biological preconcentrator. United States: N. p., 2008.
Web.
Manginell, Ronald P, Bunker, Bruce C, & Huber, Dale L. Biological preconcentrator. United States.
Manginell, Ronald P, Bunker, Bruce C, and Huber, Dale L. Tue .
"Biological preconcentrator". United States. https://www.osti.gov/servlets/purl/943499.
@article{osti_943499,
title = {Biological preconcentrator},
author = {Manginell, Ronald P and Bunker, Bruce C and Huber, Dale L},
abstractNote = {A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {9}
}
Works referenced in this record:
Sample pretreatment on microfabricated devices
journal, February 2002
- Lichtenberg, J.
- Talanta, Vol. 56, Issue 2
Synthesis of Poly( N- isopropylacrylamide) on Initiator-Modified Self-Assembled Monolayers
journal, May 2001
- Ista, Linnea K.; Mendez, Sergio; Pérez-Luna, Víctor H.
- Langmuir, Vol. 17, Issue 9
A new fabrication process for planar thin-film multijunction thermal converters
journal, April 2001
- Wunsch, T. F.; Kinard, J. R.; Manginell, R. P.
- IEEE Transactions on Instrumentation and Measurement, Vol. 50, Issue 2